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These bases are widely\nstudied for their simple synthesis, structural diversity, and numerous applications in pharmacology.\nThis review discusses their general structures and methods of synthesis. Schiff bases can be classified\naccording to their structure (aliphatic or aromatic), denticity, and symmetry. Schiff bases have\nthe ability to coordinate with metal ions such as copper (Cu&lt;sup&gt;2+&lt;\/sup&gt;), zinc (Zn&lt;sup&gt;2+&lt;\/sup&gt;), cobalt (Co&lt;sup&gt;2+&lt;\/sup&gt;), or nickel\n(Ni&lt;sup&gt;2+&lt;\/sup&gt;), allowing the formation of stable metal complexes, which enhances their biological properties.\nAt the biological level, Schiff bases exhibit a wide range of activities due to their imine group. These\ninclude antibacterial, antifungal, antiviral, antitubercular, anti-inflammatory, antioxidant, anticancer,\nand other activities. This biological activity can be enhanced when Schiff bases complex with transition\nmetals. In silico approaches play a crucial role in evaluating the therapeutic potential of Schiff bases\nand their complexes. These methods help predict their pharmacokinetic properties and binding affinity,\nthereby facilitating the rational design of more potent and selective therapeutic agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0113895575420281260116222032","type":"journal-article","created":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T11:55:10Z","timestamp":1774439710000},"page":"1713-1733","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exploration of Schiff Bases: Structures, Syntheses, and Biological Activities"],"prefix":"10.2174","volume":"26","author":[{"given":"Badr","family":"Sellami","sequence":"first","affiliation":[{"name":"Laboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M\u2019Sick, Hassan II University of Casablanca,Sidi Othman, Box 7955, Casablanca, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imane","family":"Yamari","sequence":"additional","affiliation":[{"name":"Laboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M\u2019Sick, Hassan II University of Casablanca,Sidi Othman, Box 7955, Casablanca, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samir","family":"Chtita","sequence":"additional","affiliation":[{"name":"Laboratory of Analytical and Molecular Chemistry, Faculty of Sciences Ben M\u2019Sick, Hassan II University of Casablanca,Sidi Othman, Box 7955, Casablanca, Morocco"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"116668","DOI":"10.1016\/j.synthmet.2020.116668","volume":"272","author":"Kolcu F.","year":"2021","unstructured":"Kolcu F.; Erdener D.; Kaya \u0130.; Synthesis and characterization of a highly selective turn-on fluorescent chemosensor for Sn2+ derived from diimine Schiff base. 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