{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:27:22Z","timestamp":1787124442493,"version":"build-2736575974"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["MRMC"],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract:<\/jats:title>\n                    <jats:p>Ganoderma lucidum (G. lucidum), a precious traditional Chinese medicinal herb belonging\nto the Polyporaceae family of fungi, exhibits remarkable pharmacological efficacy. Its main bioactive\ncomponents include Ganoderma polysaccharides, triterpenoids, amino acids, etc. These substances\nendow the fungus with diverse functions, such as anti-inflammatory, antioxidant, skin barrier\nrepair-promoting, and skin microbiota-regulating activities via multi-target effects, providing a\nnatural candidate strategy for the prevention and adjuvant treatment of diseases associated with skin\nhomeostasis imbalance. As the body's principal barrier tissue, the skin's homeostatic maintenance is\nessential for defense against external insults and the promotion of cutaneous health. The interplay of\nendogenous and exogenous factors, including genetic background, oxidative stress (OS), and ultraviolet\nradiation, tends to disrupt this dynamic balance and induce various skin disorders. In recent\nyears, with increasing public attention to skin health, the application of natural Chinese herbal ingredients\nsuch as G. lucidum in the field of skin health has attracted extensive interest. However, the\nmolecular mechanisms underlying the multi-component synergistic regulation of cutaneous homeostasis\nby G. lucidum remain incompletely elucidated, and clinical translational research requires further\nintensification. This paper systematically reviews the structural characteristics, extraction processes,\nand biological properties of the main bioactive components of G. lucidum, deeply explains\nits regulatory mechanism for repairing skin homeostasis from four dimensions, and compares the\ndifferences in action targets and efficacy of different active components, thereby providing a theoretical\nreference for the development of skincare products containing G. lucidum ingredients and the\nclinical treatment of skin diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0113895575459119260729112156","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:03:21Z","timestamp":1787123001000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Multidimensional Research Progress of Ganoderma Lucidum Active Components in Regulating Skin Homeostasis"],"prefix":"10.2174","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9090-1436","authenticated-orcid":true,"given":"Hui","family":"Zhao","sequence":"first","affiliation":[{"name":"Depertment of College of Medical Technology, Beihua University, Jilin City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1777-0376","authenticated-orcid":true,"given":"Kaixin","family":"Wu","sequence":"additional","affiliation":[{"name":"Depertment of College of Medical Technology, Beihua University, Jilin City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8142-1689","authenticated-orcid":true,"given":"Shangbo","family":"Zhang","sequence":"additional","affiliation":[{"name":"Depertment of College of Medical Technology, Beihua University, Jilin City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Depertment of College of Medical Technology, Beihua University, Jilin City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fanli","family":"Kong","sequence":"additional","affiliation":[{"name":"Depertment of College of Medical Technology, Beihua University, Jilin City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongchao","family":"Liu","sequence":"additional","affiliation":[{"name":"Depertment of College of Medical Technology, Beihua University, Jilin City, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Mini-Reviews in Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113895575459119260729112156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/257015\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113895575459119260729112156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T07:03:39Z","timestamp":1787123019000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/257015\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,3]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0113895575459119260729112156","relation":{},"ISSN":["1389-5575"],"issn-type":[{"value":"1389-5575","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2025-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-07","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}