{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:21:41Z","timestamp":1789125701592,"version":"build-2803163510"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MRMC"],"published-print":{"date-parts":[[2026,9,7]]},"abstract":"\n Introduction:<\/jats:title>\n To examine the design, synthesis, and pharmacological potential of novel\nartemisinin-isatin hybrid compounds as a strategy to overcome drug resistance and expand therapeutic\napplications beyond malaria.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n Researchers employed molecular hybridization techniques\u2014specifically Cu-promoted\nazide-alkyne cycloaddition, etherification, and esterification\u2014to covalently link modified isatin\nmoieties to the artemisinin scaffold. These methods produced diverse series of triazole, two-carbon,\nand ester-tethered hybrids. The compounds were evaluated using MTT assays to determine biological\nactivity against various cancer cell lines.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n 3c and 3d: Demonstrated efficacy against breast cancer lines comparable to the standard\ndrug doxorubicin.\nHybrid 5d: Showed significant anti-leukemic activity with an enhanced safety profile.\nSAR Analysis: Structure-activity relationship (SAR) data indicated that therapeutic effectiveness is\nhighly dependent on the length of the alkyl linker (with two carbons being ideal) and specific modifications\nat the C-3 and C-5 positions.<\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n The review discussed the preparation and biological activities of artemisinin and isatin\nhybrid molecules. It has been discussed that after the resistant reported against artemisinin, several\napproaches have been tried to improve the efficacy of drugs in the treatment of deadly diseases like\nmalaria. It has been found that hybrids like artemisinin-1,2,3-triazole-isatin, dihydroartemisininisatin,\ntwo-carbon tethered artemisinin\u2013isatin hybrids, ester tethered artemisinin-isatin hybrids, ester\ntethered artemisinin-isatin hybrids reported better efficacy. Also, the comparison between linkers\nshowed that alkyl linkers provide more potency than 1,2,3- triazole linkers for artemisinin and isatin\nhybrids.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Artemisinin-isatin hybrids represent a promising new class of pharmaceuticals that\nutilize synergy to target multiple cellular pathways. These hybrids offer a robust approach for treating\ncomplex diseases, including aggressive breast cancer and leukemia, while addressing the challenges\nof drug resistance.<\/jats:p>\n <\/jats:sec>","DOI":"10.2174\/0113895575459849260822123712","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:03:43Z","timestamp":1789124623000},"source":"Crossref","is-referenced-by-count":0,"title":["Harnessing Synergy: A Review on the Synthesis and Bioactivity of\nArtemisinin-Isatin Hybrid Molecules"],"prefix":"10.2174","volume":"26","author":[{"given":"Vishal","family":"Choudhary","sequence":"first","affiliation":[{"name":"Department of Chemistry, School of Applied and Life Sciences, Uttaranchal University, Dehradun, 248007, Uttarakhand,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aanya","family":"Saini","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Applied and Life Sciences, Uttaranchal University, Dehradun, 248007, Uttarakhand,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel F.","family":"Freeman","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Applied and Life Sciences, Uttaranchal University, Dehradun, 248007, Uttarakhand,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yash","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Applied and Life Sciences, Uttaranchal University, Dehradun, 248007, Uttarakhand,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manvika","family":"Karnatak","sequence":"additional","affiliation":[{"name":"Department of Chemistry, School of Applied and Life Sciences, Uttaranchal University, Dehradun, 248007, Uttarakhand,India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Mini-Reviews in Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113895575459849260822123712","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/258074\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113895575459849260822123712","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T11:03:54Z","timestamp":1789124634000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/258074\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,7]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0113895575459849260822123712","relation":{},"ISSN":["1389-5575"],"issn-type":[{"value":"1389-5575","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,7]]}}}