{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:56:52Z","timestamp":1790837812551,"version":"4.1.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MRMC"],"published-print":{"date-parts":[[2026,9,29]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract:<\/jats:title>\n                    <jats:p>Pyrimidines and their derivatives constitute an important class of six-membered aromatic\nheterocyclic compounds due to their widespread occurrence in biologically active molecules and\ntheir therapeutic and synthetic organic chemistry applications. Pyrimidine derivatives have been\nfound to exhibit numerous biological activities, such as anti-cancer, anti-bacterial, anti-diabetic, anti-\ninflammatory, anti-viral, anti-oxidant, and anti-fungal. In recent years, increasing attention has\nbeen directed toward the development of novel pyrimidine derivatives as potential antiinflammatory\nagents, driven by the need for safer and more effective alternatives to conventional\nnon-steroidal anti-inflammatory drugs. Recent studies have highlighted their potential as antiinflammatory\nagents because they can suppress the expression and activity of several key inflammatory\nmediators. This review discusses recent advances in the synthesis of pyrimidine derivatives and\npyrimidine-fused five- and six-membered heterocycles, and their Structure\u2013Activity Relationships\n(SARs). The synthesis of pyrimidine and fused pyrimidine derivatives from starting materials such\nas enamines, guanidines, and malonitriles is also discussed, including cyclization, substitution, and\ncycloaddition reactions, is also discussed. The remarkable synthetic versatility of pyrimidine derivatives\nfurther highlights their importance as promising anti-inflammatory agents.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0113895575475582260911075657","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:11:03Z","timestamp":1790835063000},"source":"Crossref","is-referenced-by-count":0,"title":["Recent Update (2015-2025) on Synthesis of Anti-inflammatory Pyrimidine Derivatives"],"prefix":"10.2174","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8595-6488","authenticated-orcid":true,"given":"Kajal","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Chemistry, Banasthali Vidyapith-Banasthali, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7470-8468","authenticated-orcid":true,"family":"Kusum","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Banasthali Vidyapith-Banasthali, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6124-0775","authenticated-orcid":true,"family":".","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Banasthali Vidyapith-Banasthali, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4432-2197","authenticated-orcid":true,"given":"Pankaj","family":"Kumar Jain","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Banasthali Vidyapith- Banasthali, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5764-497X","authenticated-orcid":true,"given":"Sonika","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Banasthali Vidyapith-Banasthali, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Mini-Reviews in Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113895575475582260911075657","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/258989\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0113895575475582260911075657","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:11:33Z","timestamp":1790835093000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/258989\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,29]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0113895575475582260911075657","relation":{},"ISSN":["1389-5575"],"issn-type":[{"value":"1389-5575","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,29]]}}}