{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T00:39:30Z","timestamp":1759451970862,"version":"build-2065373602"},"reference-count":40,"publisher":"Bentham Science Publishers Ltd.","issue":"7","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMM"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Increased expression of MRP 1 in AML patients results in the\nefflux of drugs from the cells, preventing the patient from achieving remission or\npotentially leading to relapse. Several studies have demonstrated that early\nidentification of ABC transporter may yield favorable outcomes.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Aims and objectives:<\/jats:title>\n<jats:p>The objectives of the study were to investigate the correlation\nbetween MRP 1 gene expression and MRP 1 protein levels and the response to\nremission induction in AML patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Method:<\/jats:title>\n<jats:p>A total of 40 AML patients were recruited from March 2021 to June 2022.\nPeripheral blood was collected in two tubes (yellow and purple top) to assess the MRP\n1 gene and protein. For MRP 1 gene assessment, RNA was isolated from blood\nsamples, cDNA was prepared, and qRT-PCR was performed to analyze gene\nexpression. The relationship between the gene and complete remission was\ndetermined. Identification of MRP 1 protein was conducted using ELISA, and the\nrelationship between protein levels and complete remission (CR) was explored.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Most of the patients were aged between 25 and 39 years, encompassing\nboth males and females. This study observed a clinical correlation between MRP 1\ngene expression and complete remission. The findings revealed that 69.2 percent of\npatients with high gene expression failed to achieve complete remission, whereas the\nanalysis of MRP 1 protein in relation to complete remission showed no statistical\nsignificance. The MRP1 gene showed high expression (66.7%) in patients with FLT3\nmutation, whereas low expression of MRP1 was associated with a high occurrence\n(60%) of NMP1 mutation.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Further comprehensive multicenter studies with larger sample sizes are\nrequired to validate the findings of this study. It is recommended to pinpoint the\nmechanism and regulation of MRP 1 and its interaction with other molecular pathways<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0115665240303070240626075757","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T06:32:18Z","timestamp":1720593138000},"page":"894-901","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Unveiling the Significance of MRP 1 in Achieving Complete Remission Following Induction Therapy in Acute Myeloid Leukemia"],"prefix":"10.2174","volume":"25","author":[{"given":"Saba","family":"Kamil","sequence":"first","affiliation":[{"name":"Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaheen","family":"Kouser","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Naeem","sequence":"additional","affiliation":[{"name":"Dow Research Institute, Dow University of Health Sciences, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Waqas","family":"Farroqui","sequence":"additional","affiliation":[{"name":"Department of Public Health, Dow University of Health Sciences, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaheen","family":"Sharafat","sequence":"additional","affiliation":[{"name":"Department of Pathology, Liaquat National Medical College, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farrukh Ali","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology, Dow University of Health Sciences, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghulam","family":"Haider","sequence":"additional","affiliation":[{"name":"Department of Oncology, Jinnah Postgraduate Medical Center, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noor","family":"Kamil","sequence":"additional","affiliation":[{"name":"Department of Basic\nMedical Sciences, Salim Habib University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raahim","family":"Ali","sequence":"additional","affiliation":[{"name":"Baqai Institute of Pharmaceutical Sciences, Baqai Medical University, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farah Fatima","family":"Abbass","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nehad","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramsha","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dow University of Health Sciences, Karachi, Pakistan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"journal-title":"World health statistics 2010","year":"2010","key":"ref=1","unstructured":"World Health Organization World health statistics 2010  Available From:  https:\/\/www.who.int\/publications\/i\/item\/97892415639872010"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"2173","DOI":"10.1007\/s00277-020-04163-7","volume":"99","author":"Kunadt D.","year":"2020","unstructured":"Kunadt D.; Dransfeld C.; Dill C.; Multidrug-related protein 1 (MRP1) polymorphisms rs129081, rs212090, and rs212091 predict survival in normal karyotype acute myeloid leukemia. 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