{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:10:42Z","timestamp":1778659842918,"version":"3.51.4"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMM"],"published-print":{"date-parts":[[2026,5,6]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract:<\/jats:title>\n                    <jats:p>Endothelial-to-Mesenchymal Transition (EndMT) is a regulatory\nmechanism integral to the normal developmental processes of the organism, playing\na pivotal role in sustaining the homeostasis of the intravascular milieu. However,\nwhen the internal environment exceeds the endothelium's compensatory capacity,\nexcessive EndMT can precipitate pathological alterations. EndMT is particularly\nsignificant in the pathogenesis of pulmonary diseases, including pulmonary fibrosis,\npulmonary hypertension, and lung cancer. The regulatory mechanisms underlying\nEndMT are intricate and multifaceted. Numerous signaling pathways have been\nimplicated in EndMT modulation, with the TGF-\u03b2 pathway emerging as a central\ninducer. Furthermore, research has identified that epigenetic modifications,\nmetabolic processes, hypoxia, inflammatory cytokines, and oxidative stress all\ncontribute to the regulation of EndMT. This complexity renders the interplay between\nEndMT and pulmonary vascular diseases exceedingly intricate. In this manuscript,\nwe provide a comprehensive overview of the signaling pathways and other\ninfluencing factors that govern EndMT. Concurrently, we meticulously delineate\npotential therapeutic targets to offer novel avenues and insights for the management\nof pulmonary diseases. Our synthesis of the current understanding of EndMT\nregulation is intended to inform future research and clinical strategies, potentially\nleading to more effective interventions for patients afflicted with pulmonary disorders.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0115665240408525251203054415","type":"journal-article","created":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:32:37Z","timestamp":1778657557000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Pathological Development of EndMT in Lung Diseases and its Regulatory Mechanisms"],"prefix":"10.2174","volume":"26","author":[{"given":"Jingqian","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Physiology, Naval Medical University, Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengxiang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Physiology, Naval Medical University, Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiting","family":"You","sequence":"additional","affiliation":[{"name":"School of Kinesiology, The Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai 200438, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yujian","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Kinesiology, The Key Laboratory of Exercise and Health Sciences of Ministry of Education, Shanghai University of Sport, Shanghai 200438, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaochen","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Diving Medicine of Naval Medical Center, Naval Medical University, Shanghai 200082, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7998-6444","authenticated-orcid":true,"given":"Xiaoyan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Physiology, Naval Medical University, Shanghai 200433, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115665240408525251203054415","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/253502\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115665240408525251203054415","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:32:49Z","timestamp":1778657569000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/253502\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,6]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0115665240408525251203054415","relation":{},"ISSN":["1566-5240"],"issn-type":[{"value":"1566-5240","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,6]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2025-06-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-27","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}