{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T13:19:58Z","timestamp":1775308798898,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMM"],"published-print":{"date-parts":[[2026,4,3]]},"abstract":"\n Introduction:<\/jats:title>\n Neurodegenerative disorders, including Alzheimer\u2019s Disease\n(AD), Parkinson\u2019s Disease (PD), and Age-related Macular Degeneration (AMD), are\nmarked by the progressive loss of specific neuronal populations. Astrocytes, the glial\ncells surrounding neurons, play a critical role in maintaining neuronal health by\nproviding neurotrophic support, producing antioxidants, and clearing waste.\nDysfunctional astrocytes contribute to disease progression, yet their developmental\ntrajectory and molecular regulation remain incompletely understood.<\/jats:p>\n <\/jats:sec>\n \n Method:<\/jats:title>\n This study aims to computationally characterize transcriptional differences\nbetween fetal astrocytes and neural stem cell lines to identify key regulatory genes,\npathways, and therapeutic targets relevant to astrocyte-linked neurodegeneration.\nUsing microarray data and bioinformatics pipelines, 359 Differentially Expressed\nGenes (DEGs) were identified, including 249 upregulated and 110 downregulated\ntranscripts.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n Protein\u2013Protein Interaction (PPI) network analysis revealed ten hub genes\u2014\nCOL1A1, TIMP1, LOX, COL6A1, COL6A3, COL5A1, CD44, LTBP2, ACTA2, and\nPLAU\u2014central to extracellular matrix remodeling and cell adhesion. Drug\u2013gene\ninteraction analysis linked these genes to compounds such as Estradiol valerate,\nRetinoic acid, and Calcitriol, suggesting therapeutic relevance.<\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n Enrichment analysis highlighted transcriptional regulation, apoptosis, and\nECM-receptor interaction as dominant biological themes. Key miRNA\u2013mRNA\ninteractions, including hsa-miR-877-5p and hsa-miR-767-5p targeting LOX and\nCOL6A3 were also identified.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n Overall, this study integrates transcriptomic profiling, network modeling,\nand drug\u2013gene interaction analysis to uncover astrocyte-specific molecular targets,\noffering a computational framework for therapeutic exploration in neurodegenerative\ndisease.<\/jats:p>\n <\/jats:sec>","DOI":"10.2174\/0115665240412373260224061022","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:29:16Z","timestamp":1775305756000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Network-based Transcriptomic Profiling of Fetal Astrocyte\nDifferentiation Reveals Therapeutic Targets for Neurodegenerative\nDisease"],"prefix":"10.2174","volume":"26","author":[{"given":"Arya","family":"Moftakhar-Bazkiaei","sequence":"first","affiliation":[{"name":"Department of Biology, School of Basic Sciences and Engineering, Gonbad Kavous University, GonbadKavous, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Farzaneh","sequence":"additional","affiliation":[{"name":"Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of MedicalSciences, Ahvaz, Iran"},{"name":"Clinical Research Development Unit, Imam Khomeini Hospital, Ahvaz JundishapurUniversity of Medical Sciences, Ahvaz, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Molecular Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115665240412373260224061022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/251952\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115665240412373260224061022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:29:16Z","timestamp":1775305756000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/251952\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,3]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0115665240412373260224061022","relation":{},"ISSN":["1566-5240"],"issn-type":[{"value":"1566-5240","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,3]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2025-08-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-20","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-03","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}