{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:59:38Z","timestamp":1790315978218,"version":"4.1.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["CDD"],"published-print":{"date-parts":[[2026,9,22]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract:<\/jats:title>\n                    <jats:p>Extracellular Vesicles (EVs) are active mediators of intercellular signaling in the Central\nNervous System (CNS), operating alongside synaptic transmission as an extra form of wireless communication\nbetween neurons and other brain cell types. Their biocompatibility positions them as\npromising carriers for neurobiological therapeutics; however, translation hinges on clarifying when\nand how EVs traverse the Blood-Brain Barrier (BBB) and how their design can be aligned to pathophysiology.\nWe synthesize evidence for BBB transport from in vitro models and in vivo visualization\nand functional studies and build on this foundation by outlining engineering strategies for CNS tropism\nboth to the brain and within it. Across these areas, current advances remain largely siloed despite\nclear mechanistic interdependence, underscoring the need for standardized frameworks that\nintegrate barrier biology, engineering design, and disease context. We argue that progress now depends\non two fronts: developing preclinical models that accurately capture mechanisms governing\nbidirectional EV transport through the BBB and aligning vesicle design and delivery parameters with\nthose mechanisms. Achieving this will require closer integration with biomarker discovery and greater\nstandardization across preclinical workflows. Together, these steps chart a path from proof of concept\nto clinically adaptable EV therapeutics for CNS disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0115672018485352260907113702","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:22:02Z","timestamp":1790313722000},"source":"Crossref","is-referenced-by-count":0,"title":["Engineering Principles of Extracellular Vesicles for Central Nervous System Therapies"],"prefix":"10.2174","volume":"23","author":[{"given":"Nate","family":"Roy","sequence":"first","affiliation":[{"name":"Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Zurawek","sequence":"additional","affiliation":[{"name":"McGill Group for Suicide Studies, Douglas Mental Health University Institute, Verdun, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Turecki","sequence":"additional","affiliation":[{"name":"Integrated Program in Neuroscience, McGill University, Montreal, Quebec, Canada"},{"name":"McGill Group for Suicide Studies, Douglas Mental Health University Institute, Verdun, Quebec, Canada"},{"name":"Department of Psychiatry, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115672018485352260907113702","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/258599\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115672018485352260907113702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T05:22:42Z","timestamp":1790313762000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/258599\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,22]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0115672018485352260907113702","relation":{},"ISSN":["1567-2018"],"issn-type":[{"value":"1567-2018","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9,22]]}}}