{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T11:25:11Z","timestamp":1787138711157,"version":"build-2736575974"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDD"],"published-print":{"date-parts":[[2026,8,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Fluorescent silicon nanoparticles (Si NPs) are attractive bioimaging probes,\nbut their emission is mainly confined to the blue-green region, resulting in poor penetration into tissues and strong autofluorescence interference. Moreover, most systems based on Si NPs are designed\nfor single-function imaging or sensing, which limits their use in the delivery and treatment of tumortargeted drugs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Long wavelength fluorescent Si NPs with high physicochemical stability have been synthesised and incorporated into mesoporous silica nanoparticles (MSNs) for drug delivery. Chlorine\ne6 (Ce6) has been encapsulated as a photosensitizer. The resulting nanocomposites were coated with\npolydopamine (PDA) and functionalised with folic acid (FA) to realize active tumor-targeting capability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The synthesized Si NPs showed stable long-wavelength fluorescence suitable for biological\nimaging. The FA-Si NPs-MSNs-PDA@Ce6 nanocomposite benefited from the FA-mediated targeting, increased permeability and retention effects and demonstrated increased tumor accumulation and\ncellular uptake. This strategy achieved tumor-specific fluorescence imaging, permitted real-time\ntracking of tumor cells, and boosted intracellular Ce6 delivery, thereby significantly elevating the\nphotodynamic therapy (PDT) efficiency<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>This study presents a multifunctional nanoplatform that combines long-wave fluorescence imaging and pH-sensitive photodynamic therapy, thereby overcoming the significant limitations of traditional silicon nanoparticle-based systems. Targeted delivery and controlled release of\ndrugs improve the accuracy of therapy and the effectiveness of imaging, and offer a promising strategy for tumor theranostics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>A multifunctional drug delivery nanoplatform based on Si NPs integrating targeted\nfluorescence imaging and photodynamic therapy has been successfully developed. This system holds\ngreat promise for tumor-targeted drug delivery and integrated theranostic applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0115672018487892260727155707","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:39:18Z","timestamp":1787135958000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["pH-responsive Nanomedicine Delivery Platform Based on Silicon\nNanoparticles for Imaging and Photodynamic Therapy of Tumor Cells"],"prefix":"10.2174","volume":"23","author":[{"given":"Jiahui","family":"Lu","sequence":"first","affiliation":[{"name":"School of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yihao","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changan","family":"Hao","sequence":"additional","affiliation":[{"name":"School of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoqian","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiting","family":"Yang","sequence":"additional","affiliation":[{"name":"TraditionalChinese Medical College, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-5151-9762","authenticated-orcid":true,"given":"Yakun","family":"Dou","sequence":"additional","affiliation":[{"name":"School of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Drug Delivery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115672018487892260727155707","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/257053\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115672018487892260727155707","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T10:39:23Z","timestamp":1787135963000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/257053\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,5]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0115672018487892260727155707","relation":{},"ISSN":["1567-2018"],"issn-type":[{"value":"1567-2018","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,5]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2026-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-19","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}