{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:49:08Z","timestamp":1782208148352,"version":"3.54.5"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CAR"],"published-print":{"date-parts":[[2026,6,19]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract:<\/jats:title>\n                    <jats:p>The need to improve the delivery of therapeutic compounds that require effective intracranial\ndelivery across the Blood-Brain Barrier (BBB) has generated significant interest in apolipoprotein\nE (ApoE) mimetic peptides. These synthetic equivalents of the lipid-binding receptorsinteracting\ndomains of natural ApoE are frequently reproducible when incorporated into nanocarriers\nor nano platforms, including reconstituted low-high density lipoproteins, polymeric nanoparticles,\nand liposomal systems. The progress in formulation science has led to the development of ApoE-\nfunctionalized nanoparticles and multifunctional liposomes with improved BBB translocation,\ncellular internalization, and Amyloid-beta (A\u03b2) affinity compared to conventional delivery vehicles.\nThis review provides a comprehensive discussion of the process by which ApoE mimetics can be\nused to deliver therapeutic drugs and evaluates the different nanocarrier designs adapted to deliver\ndrugs into the nervous system. Emphasis is also placed on new multifunctional systems in which\nApoE mimetics are conjugated to therapeutic or diagnostic molecules, enabling imaging of the targeted\narea, delivery to the disease site, and disease-specific activity. Although the right direction has\nbeen taken, several issues still need to be addressed before ApoE-based strategies can be implemented\nin clinical practice. The problems that continue to limit larger use include formulation stability,\nunintended off-target interactions, pharmacokinetics, and scalability of complex nanocarrier\nsystems. This review identifies key concerns needed to move ApoE-mimetic technologies toward\neffective, clinically viable therapies for central nervous system diseases, identifies the issues that\ninhibit progress, and analyzes possible methods for their management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0115672050464479260610102042","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:14:23Z","timestamp":1782206063000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Apolipoprotein E Mimetics in Targeted Drug Delivery: Advances and Therapeutic Potential for Neurodegenerative and Cardiovascular Diseases"],"prefix":"10.2174","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1168-030X","authenticated-orcid":true,"given":"Chauhan","family":"Rishika","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Mullana, Ambala, 133207, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Alzheimer Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115672050464479260610102042","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/255396\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115672050464479260610102042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T09:14:26Z","timestamp":1782206066000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/255396\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,19]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0115672050464479260610102042","relation":{},"ISSN":["1567-2050"],"issn-type":[{"value":"1567-2050","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,19]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2026-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-01","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}