{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T14:31:20Z","timestamp":1772029880100,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"9","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CTMC"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:sec>\n<jats:title\/>\n<jats:p>During and after the COVID-19 pandemic, Tuberculosis (TB) has reestablished with\nhigher figures due to interruptions in the Directly Observed Treatment Short course (DOTS) despite\nunderreporting. The rising consequences would have extended to extra-pulmonary forms of\nTB as well, including Tuberculous Meningitis (TBM). Considering the fact that TBM is the most\ndangerous and worst form of TB, we found the need to scan the literature to highlight various aspects\nof TBM. Epidemiology of TBM is proportionally less frightening, but the consequent mortalities\nand morbidities are more alarming than pulmonary TB. Here, we address critical research\ngaps in Tuberculous Meningitis that warrant further investigations. The highlighted aspects encompass\na comprehensive understanding of TBM's clinical presentation and improved diagnostic tools\nfor timely detection, the exploration of innovative chemotherapies and surgical interventions, the\nunraveling of the role of the blood-brain barrier in disease onset, investigating of the contributions\nof various brain cells to TBM development, deciphering the complex inflammatory response, exploring\nthe involvement of Matrix Metalloproteinases in tissue damage, delving into host-pathogen\ngenetics influencing susceptibility, utilizing robust in-vivo and in-vitro models for mechanistic\ninsights, and more importantly between TBM and SARS-COVID-19 are discussed. Addressing\nthese gaps will substantially advance our understanding of TBM's complex pathogenesis, contributing\nto more effective diagnostic, therapeutic, and preventive strategies against this debilitating\ndisease.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0115680266282277240122073451","type":"journal-article","created":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T17:02:55Z","timestamp":1706547775000},"page":"969-985","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Deciphering Tuberculous Meningitis: From Clinical Challenges to Novel Models and Pathogenic Pathways"],"prefix":"10.2174","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5244-4147","authenticated-orcid":true,"given":"Mohamad Mosa","family":"Mubarak","sequence":"first","affiliation":[{"name":"Clinical Microbiology PK\/PD Division, CSIR - Indian Institute of Integrative Medicine, Sanatnagar, Srinagar,\n190005, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahnawaz","family":"Majeed","sequence":"additional","affiliation":[{"name":"Clinical Microbiology PK\/PD Division, CSIR - Indian Institute of Integrative Medicine, Sanatnagar, Srinagar,\n190005, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hadiya Amin","family":"Kantroo","sequence":"additional","affiliation":[{"name":"Clinical Microbiology PK\/PD Division, CSIR - Indian Institute of Integrative Medicine, Sanatnagar, Srinagar,\n190005, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zubair Ahmad","family":"Wani","sequence":"additional","affiliation":[{"name":"Clinical Microbiology PK\/PD Division, CSIR - Indian Institute of Integrative Medicine, Sanatnagar, Srinagar,\n190005, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbass","family":"Malik","sequence":"additional","affiliation":[{"name":"Clinical Microbiology PK\/PD Division, CSIR - Indian Institute of Integrative Medicine, Sanatnagar, Srinagar,\n190005, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishfaq Ahmad","family":"Baba","sequence":"additional","affiliation":[{"name":"Clinical Microbiology PK\/PD Division, CSIR - Indian Institute of Integrative Medicine, Sanatnagar, Srinagar,\n190005, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahoor","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Clinical Microbiology PK\/PD Division, CSIR - Indian Institute of Integrative Medicine, Sanatnagar, Srinagar,\n190005, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Topics in Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115680266282277240122073451","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/226455\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115680266282277240122073451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T05:42:30Z","timestamp":1748238150000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/226455\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0115680266282277240122073451","relation":{},"ISSN":["1568-0266"],"issn-type":[{"value":"1568-0266","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2023-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-01-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}