{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T22:36:12Z","timestamp":1792276572784,"version":"4.4.0"},"reference-count":75,"publisher":"Bentham Science Publishers Ltd.","issue":"4","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CTMC"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Aims:<\/jats:title>\n                    <jats:p>This study aimed to investigate novel therapeutic approaches for Alzheimer's\ndisease (AD) by targeting the Transforming Growth Factor-\u03b2 (TGF-\u03b2) pathway using hybrid compounds\nderived from oxymatrine and amino acids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>AD remains a significant challenge in neurodegenerative disorders, necessitating\ninnovative treatments that can mitigate its devastating effects. The TGF-\u03b2 pathway has been implicated\nin AD pathogenesis, making it a promising target for therapeutic intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The objective of this study was to synthesize and evaluate the anti-AD activity of hybrid\nmolecules combining oxymatrine with different amino acids. These compounds were designed to\nenhance blood-brain barrier permeability and selectively modulate TGF-\u03b2 signaling.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Hybrid compounds were synthesized based on molecular docking studies. Characterization\nof synthesized compounds was performed using thin-layer chromatography (TLC), infrared\nspectroscopy (IR), and nuclear magnetic resonance (NMR) spectroscopy. Anti-AD activity was\nassessed using an AD rat model induced by a high-cholesterol diet, employing behavioral tests\n(radial arm maze and Hebb\u2019s Williams maze) and biochemical assays to measure A\u03b2 and TGF-\u03b2\nlevels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>All hybrid molecules exhibited significant anti-AD activity, with compound 3B demonstrating\nthe highest efficacy at a dose of 100 mg\/kg. Biochemical analyses revealed modulation of\nA\u03b2 and TGF-\u03b2 levels, indicating the compounds' potential therapeutic effects against AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>This study unveils a new class of hybrid compounds derived from oxymatrine and\namino acids that effectively target the TGF-\u03b2 pathway, offering promising therapeutic potential for\nAD. These compounds demonstrate neuroprotective properties, suggesting they may mitigate ADrelated\npathology, including tau deposition, synaptic dysfunction, and cognitive decline.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0115680266345212250404071300","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T05:28:46Z","timestamp":1744954126000},"page":"343-369","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Design, Synthesis and Anti-Alzheimer\u2019s Activity of Some Hybrid Molecule of Oxymatrine Through TGF-\u03b2"],"prefix":"10.2174","volume":"26","author":[{"given":"Subhendu","family":"Ghosh","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur Chhattisgarh, 495009,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9825-1026","authenticated-orcid":true,"given":"Yogita","family":"Dhurandhar","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur Chhattisgarh, 495009,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj Kumar","family":"Sahoo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur Chhattisgarh, 495009,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Durlav","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur Chhattisgarh, 495009,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashmita","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur Chhattisgarh, 495009,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepshikha","family":"Verma","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur Chhattisgarh, 495009,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surendra H.","family":"Bodakhe","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur Chhattisgarh, 495009,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaya","family":"Agnihotri","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur Chhattisgarh, 495009,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamta P.","family":"Namdeo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Bilaspur Chhattisgarh, 495009,India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1598","DOI":"10.1002\/alz.13016","volume":"19","year":"2023","unstructured":"2023 Alzheimer\u2019s disease facts and figures. 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