{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:57:29Z","timestamp":1775145449817,"version":"3.50.1"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","license":[{"start":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T00:00:00Z","timestamp":1774915200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/legalcode"}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CTMC"],"published-print":{"date-parts":[[2026,3,31]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>To address curcumin's limitations (e.g., poor solubility and low bioavailability),\nwe developed a curcumin-loaded ZnMgAl-layered double hydroxide nanocomposite\n(Cur@LDHs), aiming to enhance its therapeutic efficacy in wound healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>The study involves the preparation of ZnMgAl-LDHs as the carrier and the synthesis of\nCur@LDHs composites through co-precipitation. Characterization of the composites is performed\nusing XRD and FT-IR. In vitro release experiments are conducted using the dialysis bag method,\nand stability tests are performed under different temperature conditions. Biocompatibility and cell\nmigration assays are carried out on human skin fibroblast (HSF) cells. In vivo wound healing studies\nare performed on a rat model, with histological evaluation and ELISA assays for inflammatory\nfactors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>The XRD and FT-IR analyses confirm the successful loading of curcumin onto LDHs. In\nvitro release experiments show that Cur@LDHs exhibit slow and sustained release characteristics,\nreducing the cytotoxicity of pure curcumin. Cell migration experiments indicate that Cur@LDHs\nsignificantly enhance the migration rate of HSF cells compared to pure curcumin. In vivo studies\ndemonstrate that Cur@LDHs significantly promote wound healing, with reduced inflammatory\nresponses and improved re-epithelialization and collagen deposition. The ELISA results show that\nCur@LDHs effectively reduce the levels of IL-1\u03b2 and TNF-\u03b1 proteins in traumatic tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>The Cur@LDHs composite demonstrated significant potential in accelerating wound\nhealing by synergizing the sustained release of curcumin with bioactive Zn2+\/Mg2+ ions from the\nhydrotalcite carrier, which promoted fibroblast migration and collagen deposition. This dual-action\nmechanism-curcumin suppressing early inflammation (evidenced by reduced IL-1\u03b2\/TNF-\u03b1) and\nLDH-released ions enhancing tissue regeneration-outperformed free curcumin or LDHs alone in\nboth in vitro and in vivo models. While the system improved curcumin\u2019s stability and reduced cytotoxicity\ncompared to conventional delivery methods, the study acknowledges limitations such as\nthe lack of environmental simulations (humidity, infection) and a small animal cohort. Nevertheless,\nthe results position Cur@LDHs as a promising bioactive wound dressing capable of stagespecific\ntherapeutic intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Cur@LDHs demonstrated enhanced stability, sustained release, and reduced cytotoxicity\ncompared to free curcumin. The composite synergistically accelerated wound healing in vitro\n(via HSF migration) and in vivo (90% wound closure by day 7 in rats) by modulating inflammation\nand promoting tissue regeneration. This study supports Cur@LDHs as a promising bioactive\nwound dressing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0115680266397479250823161555","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:14:04Z","timestamp":1775142844000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Preparation of Curcumin-Loaded Nanocarriers and its Application on Promoting Wound Healing"],"prefix":"10.2174","volume":"26","author":[{"given":"Jingyi","family":"Yuan","sequence":"first","affiliation":[{"name":"School of Light Industry Science and Engineering, China National Light Industry, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[{"name":"School of Light Industry Science and Engineering, China National Light Industry, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijie","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Light Industry Science and Engineering, China National Light Industry, Beijing Technology and Business University, Beijing 100048, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaobo","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, The 8th of Chinese PLA General Hospital, Beijing, 100091, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug Research, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmacology, Hengyang Medical School, University of South China, Hengyang, 421001, China"},{"name":"UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, U.K"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinrui","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Light Industry Science and Engineering, China National Light Industry, Beijing Technology and Business University, Beijing 100048, China"},{"name":"UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, U.K"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Topics in Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115680266397479250823161555","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/251832\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115680266397479250823161555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T15:14:22Z","timestamp":1775142862000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/251832\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,31]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0115680266397479250823161555","relation":{},"ISSN":["1568-0266"],"issn-type":[{"value":"1568-0266","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3,31]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2025-03-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-12","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}