{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T08:04:20Z","timestamp":1780301060493,"version":"3.54.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CTMC"],"published-print":{"date-parts":[[2026,5,25]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>The prevalence of Alzheimer's disease stands at more than 55 million individuals in the\nworld, with estimates showing that the figure will increase to 152 million in 2050. Existing\ntreatment methods are mostly symptomatic and do not address the underlying molecular\ndisruptions, such as oxidative stress, mitochondrial dysfunction, and neuroinflammation.\nNeurodegeneration mediated by convergent pathways of these processes occurs through A\u03b2 and\nhyperphosphorylated Tau. This is an overall review summarizing evidence from the PubMed,\nScopus, and Web of Science databases as of 2025 on phytochemicals that can address both amyloid\nand tau pathologies simultaneously. This study presents a comprehensive assessment of more than\n100 bioactive compounds across 7 chemical families with dual anti-amyloid and anti-tau effects,\nwithout prior reviews that address separate pathological targets or isolated classes of compounds\nwith bioactivity. Major phytochemicals, such as curcumin, resveratrol, and epigallocatechin-3-\ngallate, suppress the activity of the beta-secretase, prevent the formation of amyloid fibrils, inhibit\nglycogen synthase kinase-3beta-mediated tau phosphorylation, and promote autophagy-lysosomal\nclearance. These molecules regulate NF-erythroid-2-related factor 2 signaling to inhibit reactive\noxygen species and inhibit NF-\u03baB-mediated neuroinflammation. Preclinical models show\nreductions in cognitive and neuropathological burden, but bioavailability and blood-brain barrier\npenetration pose barriers to clinical translation. Developed nanotechnology-based systems of\ndelivery and structural modifications have potential in overcoming pharmacokinetic constraints.\nThis represents a multi-target candidate therapy, a paradigm shift from the single-pathway\ntherapeutics of the past, which may provide disease-modifying strategies beyond symptom\nmanagement of Alzheimer's disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0115680266446356260226085409","type":"journal-article","created":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T19:31:01Z","timestamp":1779996661000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Neuroprotective Phytochemicals Targeting Amyloid and Tau Pathologies"],"prefix":"10.2174","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7207-1391","authenticated-orcid":true,"given":"Irfan","family":"Ahmed","sequence":"first","affiliation":[{"name":"Regional Research Institute of Unani Medicine, Mumbai, 400008, M.S., India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9257-1817","authenticated-orcid":true,"given":"Yaasir Ahmed","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Quality Assurance, AliAllana College of Pharmacy, Akkalkuwa, Dist-Nandurbar, 425415, M.S., India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8625-3145","authenticated-orcid":true,"given":"Gazala","family":"Parveen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, College ofPharmacy, Knowledge University, Kirkuk Road, Erbil, Kurdistan Region of Iraq-446015"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6259-0347","authenticated-orcid":true,"given":"Kavita","family":"Shukla","sequence":"additional","affiliation":[{"name":"Department of PharmaceuticalChemistry, Hitkarini College Of Pharmacy, Dumna Road, Jabalpur, 482001, M.P., India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manish","family":"Bhise","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics,SGSPS, Institute of Pharmacy, Akola, Affiliated to Sant Gadge Baba Amravati University, Amravati, M.S.,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0649-0606","authenticated-orcid":true,"given":"Satnam","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, AIMSR, Adesh University, Barnala Road, NH-7, Bathinda, Dist, Bathinda, Punjab,India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uzma Praveen","family":"Shaikh","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Assistant Professor, Dr. Rafiq Zakaria College for Women, Chh. Sambhaji Nagar,Aurangabad, 431001, M.S., India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafi","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Botany, Maharashtra College of Arts, Science and Commerce,Mumbai, 400008, M.S., India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-0006-2672","authenticated-orcid":true,"given":"Israr","family":"Ansari","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Sardar Patel College of Pharmacy, Medical CollegeRoad, Gorakhpur, U.P., 273013, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Sardar Patel College of Pharmacy, Medical CollegeRoad, Gorakhpur, U.P., 273013, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Topics in Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115680266446356260226085409","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/254552\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115680266446356260226085409","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T07:34:54Z","timestamp":1780299294000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/254552\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0115680266446356260226085409","relation":{},"ISSN":["1568-0266"],"issn-type":[{"value":"1568-0266","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,25]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2025-10-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-31","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}