{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T08:04:36Z","timestamp":1784189076498,"version":"3.55.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CTMC"],"published-print":{"date-parts":[[2026,7,9]]},"abstract":"<jats:sec>\n                    <jats:title>introduction:<\/jats:title>\n                    <jats:p>Diabetes mellitus (DM) is characterized by hyperglycemia, insulin resistance, and pancreatic \u03b2-cell failure, necessitating novel treatments. Garcinia atroviridis, rich in hydroxy citric acid (HCA), flavonoids, and polyphenols, shows potential against diabetes<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>materials and methods:<\/jats:title>\n                    <jats:p>in vitro and in vivo studies assessed its effects on glucose absorption, enzyme inhibition, and glycemic control in diabetic rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>results:<\/jats:title>\n                    <jats:p>The extract exhibited significant total phenolic (10.09 \u00b1 0.24 mg GAE\/g) and flavonoid (9.44 \u00b1 0.11 mg QE\/g) content. It demonstrated moderate direct antioxidant activity (DPPH IC\u2085\u2080 15.14 \u00b1 0.55 mg\/mL) and inhibited \u03b1-glucosidase, \u03b1-amylase, and DPP-4 (IC\u2085\u2080 35.04 \u00b1 0.22 mg\/mL, 22.21 \u00b1 0.13 mg\/mL). Crucially, in L6 myoblast cells, it enhanced glucose absorption (165.25% at 62.5 \u00b5g\/mL) without cytotoxicity (IC\u2085\u2080 3.12 \u00b1 0.027 mg\/mL). In diabetic rats, G. atroviridis (400 mg\/kg) significantly reduced fasting blood glucose (69.33 mg\/dL by day 21) and improved glucose tolerance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>discussion:<\/jats:title>\n                    <jats:p>The findings suggest that the antidiabetic potential of G. atroviridis is likely driven by a multi-mechanistic synergy between its moderate direct antioxidant capacity, enzyme inhibition, and, most notably, its potent ability to enhance cellular glucose uptake at low concentrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>conclusion:<\/jats:title>\n                    <jats:p>This positions G. atroviridis as a promising natural adjunct for diabetes treatment, warranting further research into its active compounds and clinical applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0115680266449106260626205346","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T07:15:01Z","timestamp":1784186101000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Antidiabetic Potential of Garcinia atroviridis Griff: In Vitro and In Vivo Evaluation of Glucose Metabolism and Enzyme Inhibition"],"prefix":"10.2174","volume":"26","author":[{"given":"ibrahim","family":"mahmood","sequence":"first","affiliation":[{"name":"Alrafidain University College dentistry department Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Zhu","sequence":"additional","affiliation":[{"name":"Universiti Kebangsaan Malaysia Department of Food Science, Faculty of Science and Technology Bangi, Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"douglas","family":"law","sequence":"additional","affiliation":[{"name":"INTI International University Faculty of Health and Life Sciences Nilai Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lunasmrita","family":"Saikia","sequence":"additional","affiliation":[{"name":"Assam Down Town University Faculty of Pharmaceutical Science Guwahati India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partha Pratim","family":"Dutta","sequence":"additional","affiliation":[{"name":"Assam Down Town University Department of Pharmaceutical Sciences Guwahati India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saikat","family":"Sen","sequence":"additional","affiliation":[{"name":"Assam Down Town University Department of pharmaceutical Science Guwahati India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"shazrul","family":"fazry","sequence":"additional","affiliation":[{"name":"Universiti Kebangsaan Malaysia Department of Food Science, Faculty of Science and Technology Bangi, Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Najm","sequence":"additional","affiliation":[{"name":"Universiti Kebangsaan Malaysia Department of Food Sciences, Faculty of Science and Technology Bangi, Selangor Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Topics in Medicinal 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