{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T07:18:16Z","timestamp":1788160696161,"version":"build-2803163510"},"reference-count":126,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRR"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Fibromyalgia is associated with dyscognition or \u201cfibro fog\u201d, of unknown aetiology. The hippocampus has major roles in memory and cognition. Certain bacterial and viral infections can cause hippocampal changes. Furthermore, citrullinated proteins may accumulate in the hippocampus in Alzheimer\u2019s disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>This study aimed to test the hypothesis that hippocampal functioning in fibromyalgia is associated with markers of bacterial and viral infection and serum anti-cyclic citrullinated pep-tide antibody (anti-CCP) levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Hippocampal functioning was assessed in 26 female patients and one male patient with the Paired Associates Learning Total Errors (Adjusted) (PALTEA) in a cross-sectional study. Se-rum samples, for markers of bacterial and viral infections and anti-CCP, were taken within an hour of cognitive assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Generalised linear modelling (p = 0.01) with PALTEA as the dependent variable showed significant coefficients for Borrelia outer surface protein peptide mix (p = 0.025), lymphocyte function-associated antigen-1 (p = 0.003), Ehrlichia chaffeensis plus Anaplasma phagocytophi-lum (p = 0.048), Mycoplasma pneumoniae immunoglobulin (Ig) G (p = 0.003), coxsackievirus B1 IgA (p = 0.010), echovirus IgG (p = 0.012), and anti-CCP IgG (p = 0.003).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>On the basis of this study, it is suggested that, in fibromyalgia patients complaining of dyscognition, there may be merit in assessing lymphocyte function-associated antigen-1, anti-CCP IgG, and evidence of infection with Borrelia species, Ehrlichia chaffeensis, Anaplasma phagocytophilum, Mycoplasma pneumoniae, coxsackievirus B1, and echovirus.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0115733971382873251015113608","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T10:47:06Z","timestamp":1768560426000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hippocampal Function and Markers of Citrullinated Proteins and Bacterial and Viral Infection in Fibromyalgia"],"prefix":"10.2174","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6101-0139","authenticated-orcid":true,"given":"Basant K.","family":"Puri","sequence":"first","affiliation":[{"name":"Department of Molecular Biology, C.A.R., Cambridge, UK"},{"name":"Department of Psychology, Neapolis University Paphos.Paphos, Cyprus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8521-6534","authenticated-orcid":true,"given":"Gary S.","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Southampton, Southampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6803-8588","authenticated-orcid":true,"given":"Rosemarie","family":"Preyer","sequence":"additional","affiliation":[{"name":"Department of ImmuneAnalytics, GenID, Strassberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9497-9544","authenticated-orcid":true,"given":"Armin","family":"Schwarzbach","sequence":"additional","affiliation":[{"name":"Department of Pathology, Arminlabs, Augsburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1315","DOI":"10.1097\/MS9.0000000000001722","volume":"86","author":"Akel A.","year":"2024","unstructured":"Akel A.; Sarhan M.Y.; Dwairy M.A.; The prevalence of fibromyalgia in adults at Al-Karak Jordan: A cross-sectional study. 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