{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T04:54:16Z","timestamp":1784868856705,"version":"3.55.0"},"reference-count":25,"publisher":"Bentham Science Publishers Ltd.","issue":"10","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDR"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Diabetic peripheral neuropathy (DPN) is the prevalent microvascular\ncomplication of diabetes mellitus (DM). 30-50% of diabetics are likely to be affected by DPN. It\nsignificantly impacts the skeletal muscles, resulting in an accelerated loss of muscle mass. The\nobjective of this systematic review was to evaluate the ankle and foot muscle changes in diabetic\nperipheral neuropathy using ultrasound.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Method:<\/jats:title>\n<jats:p>A comprehensive search was conducted in Scopus, Embase, and PubMed databases,\nwhich yielded 64 studies, out of which 5 studies are included in this meta-analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Result:<\/jats:title>\n<jats:p>The meta-analysis shows that the thickness and cross-section area of the extensor digitorum\nbrevis muscle are reduced in DPN as compared to the control group with p-value&lt;0.004\nand p-value&lt;0.001, respectively. The thickness of MIL muscle was also smaller in DPN\np-value=0.02. Similarly, the thickness and CSA of AH muscle are also reduced in DPN patients\ncompared to the control group, with p-values of 0.21 and 0.14.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Meta-analysis reveals that diabetic peripheral neuropathy (DPN) patients have reduced\nfoot muscle thickness and cross-sectional area (CSA) compared to controls without neuropathy.\nThis highlights the importance of ultrasound in detecting muscle atrophy early in diabetic\npatients since it provides objective measures beyond traditional screening with its real-time\nand non-invasive nature.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0115733998310010240711051523","type":"journal-article","created":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T05:09:57Z","timestamp":1727413797000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ultrasound Evaluations of Ankle and Foot Muscles in Diabetic Peripheral Neuropathy Systematic Review with Meta-Analysis"],"prefix":"10.2174","volume":"21","author":[{"given":"Sharath","family":"S.","sequence":"first","affiliation":[{"name":"Department of Medical Imaging Technology, Manipal College of Health Professions, Manipal Academy of Higher Education,\nManipal, 576104, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajagopal","family":"Kadavigere","sequence":"additional","affiliation":[{"name":"Department of Radio Diagnosis and Imaging, Kasturba Medical College,\nManipal Academy of Higher Education, Manipal, 576104, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G. Arun","family":"Maiya","sequence":"additional","affiliation":[{"name":"Centre for Podiatry &amp; Diabetic Foot\nCare and Research, Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher\nEducation, Manipal, 576104, Karnataka, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","author":"Atlas IDFD","year":"2019","unstructured":"Atlas IDFD;   Available from:  https:\/\/idf.org\/aboutdiabetes\/type-2-diabetes.html2019"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1016\/j.clinthera.2017.05.001","volume":"39","author":"Parasoglou P.","year":"2017","unstructured":"Parasoglou P.; Rao S.; Slade J.M.; Author C.T.; Declining skeletal muscle function in diabetic peripheral neuropathy. 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