{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:32:39Z","timestamp":1791592359350,"version":"4.3.4"},"reference-count":50,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CHYR"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Declined kidney function associated with hypertension is a danger for\ncognitive deficits, dementia, and brain injury. Cognitive decline and vascular dementia (VaD)\nare serious public health concerns, which highlights the urgent need for study on the risk factors\nfor cognitive decline. Cysteinyl leukotriene (CysLT1) receptors are concerned with regulating\ncognition, motivation, inflammatory processes, and neurogenesis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This research aims to examine the consequence of montelukast (specific CysLT1 antagonist) in renovascular hypertension 2-kidney-1-clip-2K1C model-triggered VaD in experimental animals.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>2K1C tactics were made to prompt renovascular hypertension in mature male rats.\nMorris water maze was employed to measure cognition. Mean arterial pressure (MAP), serum\nnitrite levels, aortic superoxide content, vascular endothelial activity, brain\u2019s oxidative stress\n(diminished glutathione, raised lipid peroxides), inflammatory markers (IL-10, IL-6, TNF-\u03b1),\ncholinergic activity (raised acetylcholinesterase), and cerebral injury (staining of 2, 3, 5-\ntriphenylterazolium chloride) were also examined.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Montelukast in doses of 5.0 and 10.0 mg kg-1 was used intraperitoneally as the treatment drug. Along with cognitive deficits, 2K1C-operated rats showed elevated MAP, endothelial\ndysfunction, brain oxidative stress, inflammation, and cerebral damage with diminished serum\nnitrite\/nitrate. Montelukast therapy significantly and dose-dependently mitigated the 2K1Chypertension-provoked impaired behaviors, biochemistry, endothelial functions, and cerebral infarction.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The 2K1C tactic caused renovascular hypertension and associated VaD, which was\nmitigated via targeted regulation of CysLT1 receptors by montelukast administration. Therefore,\nmontelukast may be taken into consideration for the evaluation of its complete potential in renovascular-hypertension-induced VaD.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0115734021276985231204092425","type":"journal-article","created":{"date-parts":[[2024,1,9]],"date-time":"2024-01-09T06:50:15Z","timestamp":1704783015000},"page":"23-35","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Montelukast Ameliorates 2K1C-Hypertension Induced Endothelial\nDysfunction and Associated Vascular Dementia"],"prefix":"10.2174","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6178-5759","authenticated-orcid":true,"given":"Surbhi","family":"Gupta","sequence":"first","affiliation":[{"name":"Department of Pharmacology, School of Pharmacy, Bharat Institute of Technology, Partapur Bypass, Meerut, Uttar\nPradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1767-1308","authenticated-orcid":true,"given":"Prabhat","family":"Singh","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3423-007X","authenticated-orcid":true,"given":"Bhupesh","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Noida, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1007\/s43440-022-00364-1","volume":"74","author":"Sharma P.","year":"2022","unstructured":"Sharma P.; Gaur N.; Jayant S.; Salubrious effects of ulinastatin and quercetin alone or in combination in endothelial dysfunction and vascular dementia. 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