{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:54:45Z","timestamp":1790139285181,"version":"4.0.1"},"reference-count":92,"publisher":"Bentham Science Publishers Ltd.","issue":"7","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["MC"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Alternative and complementary applications of newly synthesized chemicals\nhave enhanced the prospect of finding curative treatments for liver hepatocarcinogenesis and\npancreatic cancer.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The current study investigated the curative effect of the newly synthesized drug 4-\nmethyl-N-((4-(trifluoromethoxy) phenyl) carbamoyl) benzenesulfonamide (3) against diethyl nitrosamine\n(DEN) (50 mg\/kg) and carbon tetrachloride (CCl4) (2 mg\/kg)-induced hepatocellular\ncarcinoma (HCC) and pancreatic cancer in male rats using doxorubicin as a reference drug.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The findings demonstrated that the DEN\/CCl4 treatment produced oxidative stress, as\nevidenced by an increase in MDA and a reduction in GSH levels. A temporary decline in antioxidant\nand total antioxidant capacity (TAC) was detected. An increase in the levels of TNF-\u03b1 and\nother inflammatory markers, interleukin-6 (IL-6) and B-cell lymphoma 2 (Bcl-2), was found. Our\nfindings showed that the liver and pancreas had significantly higher levels of hepatocellular carcinoma\nbiomarkers, namely \u03b1-fetoprotein and \u03b1-L-Fucosidase (\u03b1-FU). Changes in the biomarkers of\nhepatic function were also seen, with elevated levels of \u03b3-glutamyltransferase (GGT), alkaline\nphosphatase (ALP), and transaminases (AST, ALT). Our findings were supported by immunohistochemical\nand pathological examinations, which revealed considerable improvement in liver\nand pancreatic tissues after treatment with medication 3 when compared to normal healthy rats.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>To summarize, the new synthetic medication 3 could be an effective chemotherapeutic\nmethod for treating DEN and CCl4-induced HCC and pancreatic cancer.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0115734064308484240820080153","type":"journal-article","created":{"date-parts":[[2024,9,5]],"date-time":"2024-09-05T06:27:23Z","timestamp":1725517643000},"page":"692-706","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Preclinical Study on 4-Methyl-N-((4-(trifluoromethoxy)phenyl) carbamoyl)-benzenesulfonamide as a Potent Chemotherapeutic Agent against Liver and Pancreatic Carcinogenesis in Rats: Immunohistochemical and Histopathological Studies"],"prefix":"10.2174","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1283-2157","authenticated-orcid":true,"given":"Farid","family":"M. 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