{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T04:16:47Z","timestamp":1747801007865,"version":"3.41.0"},"reference-count":37,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDS"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:sec>\n<jats:title>Introduction:<\/jats:title>\n<jats:p>Serotonin syndrome is a potentially life-threatening condition that can\noccur as a result of the therapeutic use of serotonergic medications or drug interaction. In this\nstudy, we describe two cases of serotonin syndrome-associated hypertensive crisis following\nlinezolid use.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Case Presentation:<\/jats:title>\n<jats:p>The first patient was a 52-year-old female who was admitted due to a diabetic\nfoot infection and pneumonia associated with a decreased consciousness level. Serotonin syndrome\noccurred 24 hours after starting the linezolid use. Resistant hypertension was the main\nhemodynamic finding. It could not be controlled with amlodipine, valsartan, prazosin, and nitroglycerin\ninfusion. Resistant hypertension and other symptoms of serotonin syndrome were resolved\nabout 48 hours after discontinuation of linezolid use.\nThe second case was a man with a history of kidney transplant, diabetes, and hypertension. He\nwas admitted to the ICU due to severe COVID-19. Broad-spectrum antibiotics [linezolid,\ncefepime], and remdesivir was initiated. Following intubation, continuous infusion of fentanyl\nwas used for sedation. Within 24 hours after fentanyl and linezolid initiation, severe agitation,\neye clonus, hyperreflexia, hypertension [160-186 \/90-110 mmHg], and tachycardia [&gt;100\/min]\nwere noted. With the possible diagnosis of serotonin syndrome, fentanyl was discontinued, and\nmorphine was initiated. The patient\u2019s symptoms improved 48 hours after discontinuation of fentanyl.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Both patients had a history of well- controlled hypertension. Hypertensive crisis has\noccurred after recent or concurrent use of serotonergic agents with linezolid. A thorough evaluation\nof the patient\u2019s medical history and current condition can help clinicians prevent this syndrome\nin critically ill patients.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0115748863299100240507052341","type":"journal-article","created":{"date-parts":[[2024,6,7]],"date-time":"2024-06-07T07:24:52Z","timestamp":1717745092000},"page":"241-246","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Hypertensive Crisis Associated with Serotonin Syndrome Following Linezolid Administration: Report of Two Cases"],"prefix":"10.2174","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0640-356X","authenticated-orcid":true,"given":"Foroud","family":"Shahbazi","sequence":"first","affiliation":[{"name":"Clinical Research Development Center, Imam Reza Hospital, Kermanshah University of Medical Sciences, Kermanshah, Iran"},{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0154-8487","authenticated-orcid":true,"given":"Lida","family":"Shojaei","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1112","DOI":"10.1056\/NEJMra041867","volume":"352","author":"Boyer E.W.","year":"2005","unstructured":"Boyer E.W.; Shannon M.; The serotonin syndrome. 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