{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:58:47Z","timestamp":1786121927308,"version":"build-2736575974"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CDS"],"published-print":{"date-parts":[[2026,7,27]]},"abstract":"\n Introduction:<\/jats:title>\n Metabolic disorders have grown more common, with obesity representing\na significant chronic illness that leads to various severe health complications. The Obesity Atlas\n2022 predicts one billion obese people by 2030. Contributors to obesity encompass heightened oxidative\nstress, hyperlipidemia, hunger enhancement, fat accumulation, insulin resistance, and diminished\ncaloric expenditure. Numerous synthetic interventions for obesity are accessible today ;\nnonetheless, they frequently entail detrimental side effects. This research aimed to investigate the\nformulation of a prospective anti-obesity drug derived from plant origins.<\/jats:p>\n <\/jats:sec>\n \n Methods:<\/jats:title>\n The anti-obesity effectiveness of a polyherbal formulation, derived from the ethanolic\nextract of both Hugonia mystax and Blumea lacera in a 1:1 ratio, was assessed in female mice\nwith progesterone-induced obesity.<\/jats:p>\n <\/jats:sec>\n \n Results:<\/jats:title>\n The preliminary phytochemical screening of the formulation specifies the presence of\nphenolic acids, flavonoids, and tannins. In accordance to OECD recommendations, 200 mg\/kg\nand 400 mg\/kg were designated after performing acute oral toxicity assessment as a low dose\nand high dose. During the study, body weight, BMI, abdomen circumference, glucose levels, lipid\nprofile, SGOT, SGPT, atherogenic index, lipid peroxidation (LPO), and glutathione (GSH)\nlevels were evaluated in all groups. The treatment markedly corrected the abnormal levels of\nthese parameters and dramatically restored GSH levels.<\/jats:p>\n <\/jats:sec>\n \n Discussion:<\/jats:title>\n Metabolic disorders, especially obesity, are increasing globally. Synthetic therapies\nhave negative consequences; therefore, exploration of plant substitutes is encouraged A polyherbal\nextract of Hugonia mystax and Blumea lacera has shown significant anti-obesity properties\nin mice. It restored biochemical parameters, likely due to phytochemicals such as polyphenols.\nHistological examination validated its therapeutic efficacy.<\/jats:p>\n <\/jats:sec>\n \n result:<\/jats:title>\n The preliminary phytochemical analysis of the formulation indicated the presence of phenolic acids, flavonoids, and tannins. In accordance to OECD recommendations, doses of 200 mg\/kg and 400 mg\/kg were designated after acute oral toxicity assessment. During the study, body weight, BMI, abdomen circumference, glucose levels, lipid profile, SGOT, SGPT, atherogenic index, lipid peroxidation (LPO), and glutathione (GSH) levels were evaluated in all groups. The treatment markedly corrected the abnormal levels of these parameters and dramatically restored GSH levels.<\/jats:p>\n <\/jats:sec>\n \n Conclusion:<\/jats:title>\n The formulation's efficacy in addressing obesity is likely attributable to the presence\nof polyphenols, saponins, and terpenoids. Histopathological examination of hepatic and adipose\ntissues further corroborated the anti-obesity efficacy of the polyherbal formulation. Future\nresearch will focus on isolating and identifying the active chemicals in both plants to better understand\ntheir composition.<\/jats:p>\n <\/jats:sec>","DOI":"10.2174\/0115748863396631251005190202","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T07:36:54Z","timestamp":1786088214000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Investigating the Therapeutic Potential of a Polyherbal Formulation in Progesterone-induced Obesity: Insights from Preclinical Studies"],"prefix":"10.2174","volume":"21","author":[{"given":"Devendra Shriram","family":"Shirode","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune, 44, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aishwarya Sambhaji","family":"Patil","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune, 44, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak S.","family":"Khobragade","sequence":"additional","affiliation":[{"name":"Datta Meghe College of Pharmacy, Datta Meghe Institute of Higher Education and Research, Sawangi (M) Wardha, 442001, Maharashtra, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunil Kumar","family":"Kadiri","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmaceutical Sciences, Dayananda Sagar University, Kanakapura Road, Bengaluru South, Bengaluru, Karnataka, 562112, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmaceutical Sciences, Dayananda Sagar University, Kanakapura Road, Bengaluru South, Bengaluru, Karnataka, 562112, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Drug Safety"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115748863396631251005190202","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/256699\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115748863396631251005190202","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T07:36:56Z","timestamp":1786088216000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/256699\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,27]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0115748863396631251005190202","relation":{},"ISSN":["1574-8863"],"issn-type":[{"value":"1574-8863","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7,27]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2025-04-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-15","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}