{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:12:24Z","timestamp":1788423144970,"version":"build-2803163510"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["RRCT"],"published-print":{"date-parts":[[2026,8,29]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract:<\/jats:title>\n                    <jats:p>Novel chemotherapeutic drugs that can fight multidrug-resistant bacteria are desperately\nneeded due to the fast growth of antimicrobial resistance (AMR). As a favoured scaffold in medicinal\nchemistry, the naturally produced indole derivative isatin (1H-indole-2,3-dione) is found in microorganisms,\nplants, and the metabolic pathways of mammals, has garnered significant interest.\nIsatin is a crucial pharmacophore for the creation of broad-spectrum antibacterial medicines because\nof its adaptable chemical structure and ease of structural alteration at several reactive locations. The\ntherapeutic potential of isatin and its derivatives against bacterial, fungal, viral, and microbacterial\ndiseases is well highlighted in this study. Schiff bases, Mannich bases, thiosemicarbazones, azole,\nfuran, sulfonamide, fluoroquinolone, chalcone, and coumarin conjugates are among the many isatinbased\nhybrids and analogs that show strong and specific antimicrobial action. According to mechanistic\ninvestigations, these compounds function via a variety of mechanisms, including biofilm suppression,\nmembrane disruption, interference with DNA gyrase and topoisomerase IV, inhibition of\ncell-wall production, and targeting vital enzymes like FtsZ and CrtM. To enhance biological potency\nand overcome drug resistance, electronic substituents, linker flexibility, and hybridization techniques\nare crucial, according to structure\u2013activity relationship (SAR) studies. The clinical approval of numerous\nisatin-based drugs, including sunitinib and nintedanib, for the treatment of cancer, as well as\nthe evaluation of other drugs, like TD-1792 and Ro 23-9424, for the treatment of infectious diseases,\ndemonstrate the translational success of this scaffold. This review focuses on significant advancements,\nprocedures, and potential treatments in isatin-based antimicrobial research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0115748871472073260820151111","type":"journal-article","created":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T06:46:08Z","timestamp":1788072368000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Isatin-based Strategies for Microbial Infections: A Multifaceted Perspective"],"prefix":"10.2174","volume":"21","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4028-0855","authenticated-orcid":true,"given":"Radhika","family":"Sharma","sequence":"first","affiliation":[{"name":"Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh,203201, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4090-1272","authenticated-orcid":true,"given":"Manjot","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh,203201, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4759-4901","authenticated-orcid":true,"given":"Pushp","family":"Kashyap","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh,203201, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8567-2729","authenticated-orcid":true,"given":"Shubhangi","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh,203201, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1033-7814","authenticated-orcid":true,"given":"Kalpana","family":"Rahate","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Greater Noida, Uttar Pradesh,203201, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Reviews on Recent Clinical Trials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115748871472073260820151111","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/257794\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0115748871472073260820151111","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:14:35Z","timestamp":1788419675000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/257794\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,29]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0115748871472073260820151111","relation":{},"ISSN":["1574-8871"],"issn-type":[{"value":"1574-8871","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8,29]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2026-01-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-21","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}