{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T05:59:36Z","timestamp":1790229576235,"version":"4.1.0"},"reference-count":77,"publisher":"Bentham Science Publishers Ltd.","issue":"5","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CSCR"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Sedative doses of propofol have recently been reported to exert positive\neffects on the developing brain, potentially enhancing later cognitive function, but the underlying\nmechanism remains unclear. This study aims to investigate changes in cell cycle status and reveal the\ndominant upstream molecular cascade following sedative-dose propofol treatment of primary neural\nstem cells (NSCs) in vitro.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Primary C57BL\/6 murine NSCs were isolated and cultured. Proliferation was assessed\nusing CCK-8 assays, direct cell counting, and EdU labeling after exposure to 10 \u03bcM propofol. Cell\ncycle distribution was analyzed by flow cytometry. Bulk RNA sequencing, qRT-PCR, and western\nblotting were used to explore potential pathways. FoxO3a overexpression via adenovirus was employed\nto confirm the mechanism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Primary NSCs, identified with &gt;95% Nestin positivity, were successfully isolated. Propofol\nat 10 \u03bcM enhanced NSC proliferation as assessed by CCK-8 assays, cell counting, and immunofluorescence.\nCell cycle analysis revealed that propofol promotes G1-S phase transition in NSCs.\nFoxO3a, a crucial component of the redox signaling pathway, was down-regulated after propofol\nexposure, along with its downstream regulator p27. Importantly, FoxO3a overexpression counteracted\npropofol's effects on cell cycle distribution and NSC proliferation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>These findings indicate that propofol promotes NSC proliferation by inhibiting FoxO3a\nnuclear translocation, a key mechanism driving the G1-S transition. This effect is concentrationdependent\nand occurs at clinically relevant sedation levels, highlighting its potential neuroprotective\nrole. The cellular context and specific signaling mediators of the FoxO3a-p27 axis warrant further\ninvestigation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>In summary, this study confirms the FoxO3a-p27 axis as a key pathway mediating\npropofol's proliferative effects on NSCs at sedative concentrations.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/011574888x440453251208150650","type":"journal-article","created":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T05:42:18Z","timestamp":1769406138000},"page":"418-429","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Propofol at a Sedative Dose Potently Activates the G1-S Phase Transition to Promote Neural Stem Cell Proliferation via Down-regulated FoxO3a-p27 Pathway"],"prefix":"10.2174","volume":"21","author":[{"given":"Liangtian","family":"Lan","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-Sen University, No. 2nd Zhongshan Road, Guangzhou,Guangdong, 510080, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keyu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-Sen University, No. 2nd Zhongshan Road, Guangzhou,Guangdong, 510080, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-Sen University, No. 2nd Zhongshan Road, Guangzhou,Guangdong, 510080, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujun","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital, Sun Yat-Sen University, No. 2nd Zhongshan Road, Guangzhou,Guangdong, 510080, P.R. 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