{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,2]],"date-time":"2026-03-02T07:56:45Z","timestamp":1772438205456,"version":"3.50.1"},"reference-count":18,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CNSAMC"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Epilepsy is a common and frequently devastating disorder affecting\nmillions of people. According to a recent survey, 1-2% of the Indian population suffers from\nmajor mental disorders and 5% suffers from minor mental disorders. Epilepsy is among those\nmental disorders that affect 30 million people worldwide. Currently, the treatment of epilepsy\ninvolves agents which modulate sodium-ion channels, enhance GABAergic transmission, and\nagents with multiple modes of action. Various classes of synthetic drugs are used to treat epilepsy,\nbut these drugs are often challenged due to their unwanted side effects. Medicinal plants\nhave been a part of human society which combating diseases from the dawn of civilization. The\nplant Cyanthillium cinereum (L.) H. Rob. is mainly found in the Himalayas from Kashmir to\nNepal at an altitude of 8000 m. Decoction of this plant is traditionally used as an anti-cancer,\nanti-malarial, anti-epileptic, and in neurosis and skin diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives:<\/jats:title>\n                    <jats:p>The present study investigated the anti-epileptic activity of Cyanthillium cinereum\nleaves against pentylenetetrazole (PTZ)-induced epileptic model in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>Plant extracts were prepared using solvents in increasing polarity viz., petroleum\nether, chloroform, ethanol, and water, using a Soxhlet apparatus. The bio-active extract was\ncharacterized using FTIR and GC techniques. In vivo antioxidants like GSH and SOD level, oxidative\nstress markers- MDA and hemoglobin and platelet count were also estimated in the animal\nbrain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Amongst all extracts tested, only ethanol extract of Cyanthillium cinereum significantly\n(p&lt;0.05) inhibited generalized tonic-clonic seizures in PTZ-induced epilepsy in mice in a\ndose (100 or 200 mg\/kg., p.o.) dependent manner. The dose of 200 mg\/kg of extract exhibited\nthe most significant effect. It is also found that treatment with ethanol extract on PTZ-induced\nepilepsy in mice significantly (p&lt;0.05) reduces the duration of convulsion and delays the onset\nof clonic convulsion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The present findings suggest that the high amounts of phenols and flavonoids in\nthe ethanol extract could be responsible for the anti-epileptic effect. Moreover, the ethanol extract\nalso restored GSH, SOD and hemoglobin and platelet level and decreased oxidative marker-\nMDA content in the mice brain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0118715249352799250512015642","type":"journal-article","created":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T06:39:23Z","timestamp":1748587163000},"page":"114-123","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Anti-epileptic Activity of Cyanthillium cinereum (L.) H. Rob. Leaves in the Experimental Pentylenetetrazole-induced Epileptic Model"],"prefix":"10.2174","volume":"26","author":[{"given":"Kundan","family":"Singh Bora","sequence":"first","affiliation":[{"name":"University Institute of Pharma Sciences, Chandigarh University, Gharuan, Mohali, Punjab-140413, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanupriya","family":"Kumari","sequence":"additional","affiliation":[{"name":"University Institute of Pharma Sciences, Chandigarh University, Gharuan, Mohali, Punjab-140413, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1055\/s-0040-1718719","volume":"40","author":"Falco-Walter J.","year":"2020","unstructured":"Falco-Walter J.; Epilepsy\u2014Definition, classification, pathophysiology, and epidemiology. 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