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In this review, we investigate how sodium butyrate influences\ncardiovascular complications of type 2 diabetes, including atherosclerosis (AS), heart failure\n(HF), hypertension, and angiogenesis. Moreover, we explore the pathophysiology of cardiovascular\ndisease in type 2 diabetes, focusing on hyperglycemia, oxidative stress, inflammation, and\ngenetic factors playing crucial roles. The review suggests that sodium butyrate can be a potential\npreventive and therapeutic agent for cardiovascular complications in individuals with type 2 diabetes.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0118715257307380240820052940","type":"journal-article","created":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T08:08:01Z","timestamp":1724918881000},"page":"1-10","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Sodium Butyrate, A Gut Microbiota Derived Metabolite in Type 2 Diabetes Mellitus and Cardiovascular Disease: A Review"],"prefix":"10.2174","volume":"23","author":[{"given":"Zeynab","family":"Sarlak","sequence":"first","affiliation":[{"name":"Department of Biology, Khorramabad branch, Islamic Azad University, Khorramabad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Narges","family":"Naderi","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bardia","family":"Amidi","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vajihe","family":"Ghorbanzadeh","sequence":"additional","affiliation":[{"name":"Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan University of Medical Sciences, Khorramabad, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1093\/cvr\/cvx197","volume":"114","author":"Steven S.","year":"2018","unstructured":"Steven S.; Dib M.; Hausding M.; Kashani F.; Oelze M.; Kr\u00f6ller-Sch\u00f6n S.; Hanf A.; Daub S.; Roohani S.; Gramlich Y.; Lutgens E.; Schulz E.; Becker C.; Lackner K.J.; Kleinert H.; Knosalla C.; Niesler B.; Wild P.S.; M\u00fcnzel T.; Daiber A.; CD40L controls obesity-associated vascular inflammation, oxidative stress, and endothelial dysfunction in high fat diet-treated and db\/db mice. 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