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Patients with thymoma-associated MG (TAMG) have many\ndifferent clinical presentations compared to non-MG thymoma (NMG), yet their gene expression\ndifferences remain unclear.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>In this study, we analyzed the Differentially Expressed Genes (DEGs) and analyzed their\nregulatory microRNAs (miRNAs) in TAMG, which will further clarify the possible pathogenesis of\nTAMG.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>DEGs were calculated using the RNA-sequencing data of TAMG and NMG downloaded\nfrom The Cancer Genome Atlas (TCGA) database. R software was then used to analyze the gene\nontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of DEGs, while\nSTRING was applied to build the protein-protein interaction (PPI) network and Cytoscape to identify\nand visualize the hub genes. Immune infiltration significances of hub genes were also explored by\nusing the TIMER database and TCGA database. Upstream microRNAs (miRNAs) of the hub genes\nwere predicted by online software.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>We comparatively analyzed the gene expression differences between TAMG and NMG\ngroups. A total of 977 DEGs were identified between the two groups (|log fold change (FC)| &gt;2,\nadjusted P value &lt;0.050), with 555 down-regulated genes and 422 up-regulated genes. Five top hub\ngenes (CTNNB1, EGFR, SOX2, ERBB2, and EGF) were recognized in the PPI network. Analysis\nbased on the TIMER and TCGA databases suggested that 5 hub genes were correlated with multiple\nimmune cell infiltrations and immune checkpoint-related markers, such as PDCD1, CTLA-4, and\nCD274, in TAMG patients. Lastly, 5 miRNAs were identified to have the potential function of regulating\nthe hub gene expression.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Our study identified 5 hub genes (CTNNB1, EGFR, SOX2, ERBB2, and EGF) and their\n5 regulatory miRNAs in TAMG, and the hub genes were correlated with multiple immune cell infiltrations\nand immune checkpoint-related markers. Our findings could help partially clarify the pathophysiology\nof TAMG, which could be new potential targets for subsequent clinical immunotherapy.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0122115366299210240823062457","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T06:13:56Z","timestamp":1724825636000},"page":"49-58","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Identification of Hub Genes and Analysis of their Regulatory miRNAs in Patients with Thymoma Associated Myasthenia Gravis Based on TCGA Database"],"prefix":"10.2174","volume":"14","author":[{"given":"Wei","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Cardiothoracic Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First Affiliated Hospital of Wannan Medical College, Wuhu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Nie","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, The First Affiliated Hospital of Wannan Medical College, Wuhu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"S260","DOI":"10.1097\/JTO.0b013e3181f1f62d","volume":"5","author":"Engels E.A.","year":"2010","unstructured":"Engels E.A.; Epidemiology of thymoma and associated malignancies. 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