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Numerous miRNAs have been proposed as potential\nindicators for periodontal disease, and their regulation might serve as a potent means of restricting\nthe disease process.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>:<\/jats:title>\n<jats:p>MiRNAs act as important immune system regulators that promote the production of many cytokines,\nincluding interferon (IFN), tumour necrosis factor (TNF), and IL-1as well as RANK. Investigations\npertaining to the use of specific miRNAs as therapeutic agents are underway. They\ncan influence a variety of regulatory organs and target several genes. Additionally, distinct components\nof the same expression pathway can be controlled by combining miRNAs and their antagonists.\nIn recent years, many miRNA delivery methods have been created for therapeutic applications.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>:<\/jats:title>\n<jats:p>Studies pertaining to the role of miRNAs in periodontal disease pathogenesis may pave the way\nfor the use of miRNAs as biomarkers of periodontal disease. A complete understanding of the\nrole of miRNA in periodontal disease and its mechanism of action can pave the way towards\ntherapeutic strategies that can reduce or even prevent the progression of periodontal diseases.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0122115366305491240708060422","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T07:59:43Z","timestamp":1722239983000},"page":"9-18","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Periodontal Tissue Homoeostasis, Immunity, the Red Complex Pathogens, and Dysbiosis: Unraveling the microRNA Effect"],"prefix":"10.2174","volume":"14","author":[{"given":"Swastik","family":"Mishra","sequence":"first","affiliation":[{"name":"Department of Periodontology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher education, Manipal,\nKarnataka, 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5559-5887","authenticated-orcid":true,"given":"Lakshmi","family":"Puzhankara","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Manipal College of Dental Sciences, Manipal, Manipal Academy of Higher education,\nManipal, Karnataka, 576104, India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"2197779","DOI":"10.1080\/20002297.2023.2197779","volume":"15","author":"Abdulkareem A.A.","year":"2023","unstructured":"Abdulkareem A.A.; Al-Taweel F.B.; Al-Sharqi A.J.B.; Gul S.S.; Sha A.; Chapple I.L.C.; Current concepts in the pathogenesis of periodontitis: from symbiosis to dysbiosis. 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