{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T14:57:01Z","timestamp":1792681021164,"version":"4.5.0"},"reference-count":39,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["MIRNA"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Critical limb ischemia (CLI) is considered the most severe form of peripheral artery disease (PAD). Nowadays, using stem cells such as mesenchymal stem cells (MSCs) to induce angiogenesis seems like a promising method for CLI therapy. Among the many factors that affect the angiogenesis process, microRNA-126 has an important role. Objective: The goal of this study was to increase the angiogenic potential of bone marrow mesenchymal stem cells (BMSCs) via using microRNA-126.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods:<\/jats:title>\n                    <jats:p>BMSCs were isolated from male C57BL\/6 inbred mice. CLI model was created by femoral artery ligation on C57BL\/6 mice. Animals were allocated to control, BMSCs, miR-126, and BMSCsmiR-126 groups, and a defined number of the cells and virus were injected 24 h after surgery. Then, wound-healing assay, functional tests, real-time PCR, histopathological evaluation, and donor cell survival were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>Results showed that BMSCs and miR-126 groups had a positive effect on angiogenesis. BMSCs miR-126 group had a significant effect on functional improvements, endothelial cell migration, neovascularization, and muscle restructures. In vivo evaluation showed that miR-126 could increase BMSCs survival and paracrine secretion of angiogenic factors such as VEGF and led to remarkable functional improvements and neovascularization in ischemic tissues.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>It can be concluded that the combination uses of BMSCs and miR-126 lead to more effective recovery from ischemic damage compared with using them alone. MiR-126 can be used as a strong modifier to reinforce the angiogenic potential, paracrine secretion, and survival of the BMSCs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0122115366332247250124130611","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T05:58:46Z","timestamp":1739426326000},"page":"234-245","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bone Marrow Mesenchymal Stem Cells Overexpressing MicroRNA-126 to Treat Critical Limb Ischemia"],"prefix":"10.2174","volume":"14","author":[{"given":"Pegah","family":"Nammian","sequence":"first","affiliation":[{"name":"Department of Molecular Medicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyedeh-Leili","family":"Asadi-Yousefabad","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, School of Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyyed Sajad","family":"Daneshi","sequence":"additional","affiliation":[{"name":"Postdoctoral Researcher, Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jafar","family":"Fallahi","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar","family":"Khajeh","sequence":"additional","affiliation":[{"name":"Bone and Joint Disease Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Mohammad Bagher","family":"Tabei","sequence":"additional","affiliation":[{"name":"Department of Genetics, Shiraz University of Medical Science, Shiraz, Iran"},{"name":"Maternal-fetal Medicine Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Razban","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, School of Advanced Medical Sciences and Technologies, Shiraz University of Medical Sciences, Shiraz, Iran"},{"name":"Stem Cells Technology Research center, Shiraz University of Medical Sciences, Shiraz, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1465","DOI":"10.1016\/j.jacc.2016.11.008","volume":"69","author":"Herman G.M.D.","year":"2017","unstructured":"Herman G.M.D.; Gornik H.L.; Barrett C.; 2016 AHA\/ACC guideline on the management of patients with lower extremity peripheral artery disease: Executive summary: A report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol  2017,69(11),1465-1508","journal-title":"J Am Coll Cardiol"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"63","DOI":"10.2147\/VHRM.S125065","volume":"14","author":"Uccioli L.","year":"2018","unstructured":"Uccioli L.; Meloni M.; Izzo V.; Giurato L.; Merolla S.; Gandini R.; Critical limb ischemia: Current challenges and future prospects. Vasc Health Risk Manag  2018,14,63-74","journal-title":"Vasc Health Risk Manag"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"187","DOI":"10.2147\/VHRM.S209241","volume":"15","author":"Duff S.","year":"2019","unstructured":"Duff S.; Mafilios M.S.; Bhounsule P.; Hasegawa J.T.; The burden of critical limb ischemia: A review of recent literature. Vasc Health Risk Manag  2019,15,187-208","journal-title":"Vasc Health Risk Manag"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"25","DOI":"10.2174\/18755631MTA2cNjgt1","volume":"20","author":"Morishita R.","year":"2020","unstructured":"Morishita R.; Shimamura M.; Takeya Y.; Combined analysis of clinical data on HGF gene therapy to treat critical limb ischemia in Japan. Curr Gene Ther  2020,20(1),25-35","journal-title":"Curr Gene Ther"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"e20190059","DOI":"10.1590\/1677-5449.190059","volume":"19","author":"Han S.W.","year":"2020","unstructured":"Han S.W.; Vergani C.A.; Junior, Reis PEO. Is gene therapy for limb ischemia a reality? J Vasc Bras  2020,19,e20190059","journal-title":"J Vasc Bras"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1007\/s12265-020-10066-9","volume":"14","author":"Bar\u0107 P.","year":"2021","unstructured":"Bar\u0107 P.; Antkiewicz M.; \u015aliwa B.; Double VEGF\/HGF gene therapy in critical limb ischemia complicated by diabetes mellitus. J Cardiovasc Transl Res  2021,14(3),409-415","journal-title":"J Cardiovasc Transl Res"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"715","DOI":"10.2478\/s11756-018-0080-z","volume":"73","author":"Khajeh S.","year":"2018","unstructured":"Khajeh S.; Razban V.; Khozani T.T.; Enhanced chondrogenic differentiation of dental pulp-derived mesenchymal stem cells in 3D pellet culture system: Effect of mimicking hypoxia. Biologia  2018,73(7),715-726","journal-title":"Biologia"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3103\/S0095452718030064","volume":"52","author":"Razban V.","year":"2018","unstructured":"Razban V.; Khajeh S.; Alaee S.; Pour M.Z.; Soleimani M.; Tube formation potential of BMSCs and USSCs in response to HIF-1\u03b1 overexpression under hypoxia. Cytol Genet  2018,52(3),236-244","journal-title":"Cytol Genet"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1089\/scd.2018.0090","volume":"28","author":"Toledo C.E.","year":"2019","unstructured":"Toledo C.E.; Rose M.; Agu E.; Enhancing retention of human bone marrow mesenchymal stem cells with prosurvival factors promotes angiogenesis in a mouse model of limb ischemia. Stem Cells Dev  2019,28(2),114-119","journal-title":"Stem Cells Dev"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"4290","DOI":"10.1038\/s41598-020-61167-z","volume":"10","author":"Petrenko Y.","year":"2020","unstructured":"Petrenko Y.; Vackova I.; Kekulova K.; A comparative analysis of multipotent mesenchymal stromal cells derived from different sources, with a focus on neuroregenerative potential. Sci Rep  2020,10(1),4290","journal-title":"Sci Rep"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.jcyt.2020.02.007","volume":"22","author":"Mohamed S.A.","year":"2020","unstructured":"Mohamed S.A.; Howard L.; McInerney V.; Autologous bone marrow mesenchymal stromal cell therapy for \u201cno-option\u201d critical limb ischemia is limited by karyotype abnormalities. Cytotherapy  2020,22(6),313-321","journal-title":"Cytotherapy"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1016\/j.jdiacomp.2016.07.026","volume":"31","author":"Zhang J.","year":"2017","unstructured":"Zhang J.; Sun X.J.; Chen J.; Increasing the miR-126 expression in the peripheral blood of patients with diabetic foot ulcers treated with maggot debridement therapy. J Diabetes Complications  2017,31(1),241-244","journal-title":"J Diabetes Complications"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"581007","DOI":"10.3389\/fonc.2020.581007","volume":"10","author":"Annese T.","year":"2020","unstructured":"Annese T.; Tamma R.; Giorgis D.M.; Ribatti D.; microRNAs biogenesis, functions and role in tumor angiogenesis. Front Oncol  2020,10,581007","journal-title":"Front Oncol"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1161\/ATVBAHA.119.312860","volume":"40","author":"Cremades P.D.","year":"2020","unstructured":"Cremades P.D.; Cheng H.S.; Feinberg M.W.; Noncoding RNAs in critical limb ischemia. Arterioscler Thromb Vasc Biol  2020,40(3),523-533","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"4883","DOI":"10.2174\/1381612826666200504120737","volume":"26","author":"Nammian P.","year":"2020","unstructured":"Nammian P.; Razban V.; Tabei S.M.B.; Yousefabad A.S.L.; MicroRNA-126: Dual role in angiogenesis dependent diseases. Curr Pharm Des  2020,26(38),4883-4893","journal-title":"Curr Pharm Des"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"2148","DOI":"10.1111\/jcmm.16192","volume":"25","author":"Zhang L.","year":"2021","unstructured":"Zhang L.; Ouyang P.; He G.; Exosomes from microRNA\u2010126 overexpressing mesenchymal stem cells promote angiogenesis by targeting the PIK3R2\u2010mediated PI3K\/Akt signalling pathway. J Cell Mol Med  2021,25(4),2148-2162","journal-title":"J Cell Mol Med"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"17539447221096940","DOI":"10.1177\/17539447221096940","volume":"16","author":"Ring A.","year":"2022","unstructured":"Ring A.; Ismaeel A.; Wechsler M.; MicroRNAs in peripheral artery disease: Potential biomarkers and pathophysiological mechanisms. Ther Adv Cardiovasc Dis  2022,16,17539447221096940","journal-title":"Ther Adv Cardiovasc Dis"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"2062","DOI":"10.1007\/s12035-022-03197-4","volume":"60","author":"Ebrahimi V.","year":"2023","unstructured":"Ebrahimi V.; moghaddam RSH, Mohammadipour A. Therapeutic potentials of microRNA-126 in cerebral ischemia. Mol Neurobiol  2023,60(4),2062-2069","journal-title":"Mol Neurobiol"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"3449","DOI":"10.1038\/s41598-020-60352-4","volume":"10","author":"Krishna S.M.","year":"2020","unstructured":"Krishna S.M.; Omer S.M.; Li J.; Morton S.K.; Jose R.J.; Golledge J.; Development of a two-stage limb ischemia model to better simulate human peripheral artery disease. Sci Rep  2020,10(1),3449","journal-title":"Sci Rep"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"4356359","DOI":"10.1155\/2020\/4356359","volume":"2020","author":"Maacha S.","year":"2020","unstructured":"Maacha S.; Paracrine mechanisms of mesenchymal stromal cells in angiogenesis. Stem Cells Int  2020,2020,4356359","journal-title":"Stem Cells Int"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"1314709","DOI":"10.1155\/2016\/1314709","volume":"2016","author":"Tao H.","year":"2016","unstructured":"Tao H.; Proangiogenic features of mesenchymal stem cells and their therapeutic applications. Stem Cells Int  2016,2016,1314709","journal-title":"Stem Cells Int"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1016\/j.yexcr.2016.04.013","volume":"344","author":"Shen C.C.","year":"2016","unstructured":"Shen C.C.; Chen B.; Gu J.T.; The angiogenic related functions of bone marrow mesenchymal stem cells are promoted by CBDL rat serum via the Akt\/Nrf2 pathway. Exp Cell Res  2016,344(1),86-94","journal-title":"Exp Cell Res"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"421","DOI":"10.1016\/j.isci.2019.05.004","volume":"15","author":"Ullah M.","year":"2019","unstructured":"Ullah M.; Liu D.D.; Thakor A.S.; Mesenchymal stromal cell homing: Mechanisms and strategies for improvement. iScience  2019,15,421-438","journal-title":"iScience"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"13234","DOI":"10.18632\/aging.103431","volume":"12","author":"Chen C.","year":"2020","unstructured":"Chen C.; Ling C.; Gong J.; Increasing the expression of microRNA-126-5p in the temporal muscle can promote angiogenesis in the chronically ischemic brains of rats subjected to two-vessel occlusion plus encephalo-myo-synangiosis. Aging  2020,12(13),13234-13254","journal-title":"Aging"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"2119","DOI":"10.1080\/15384101.2020.1788258","volume":"19","author":"Kong R.","year":"2020","unstructured":"Kong R.; Gao J.; Ji L.; Zhao D.; MicroRNA-126 promotes proliferation, migration, invasion and endothelial differentiation while inhibits apoptosis and osteogenic differentiation of bone marrow-derived mesenchymal stem cells. Cell Cycle  2020,19(17),2119-2138","journal-title":"Cell Cycle"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/iub.2531","volume":"75","author":"Huang B.","year":"2023","unstructured":"Huang B.; Wu G.; Peng C.; miR \u2010126 regulates the proliferation, migration, invasion, and apoptosis of non\u2010small lung cancer cells viaAKT2\/HK2 axis. IUBMB Life  2023,75(3),186-195","journal-title":"IUBMB Life"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1002\/cbin.11088","volume":"43","author":"Chang L.","year":"2019","unstructured":"Chang L.; Liang J.; Xia X.; Chen X.; miRNA\u2010126 enhances viability, colony formation, and migration of keratinocytes HaCaT cells by regulating PI3 K\/AKT signaling pathway. Cell Biol Int  2019,43(2),182-191","journal-title":"Cell Biol Int"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"55","DOI":"10.3892\/etm.2016.3917","volume":"13","author":"Sheng L.","year":"2017","unstructured":"Sheng L.; Mao X.; Yu Q.; Yu D.; Effect of the PI3K\/AKT signaling pathway on hypoxia-induced proliferation and differentiation of bone marrow-derived mesenchymal stem cells. Exp Ther Med  2017,13(1),55-62","journal-title":"Exp Ther Med"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/s12276-017-0014-9","volume":"50","author":"Kang I.","year":"2018","unstructured":"Kang I.; Lee B.C.; Choi S.W.; Donor-dependent variation of human umbilical cord blood mesenchymal stem cells in response to hypoxic preconditioning and amelioration of limb ischemia. Exp Mol Med  2018,50(4),1-15","journal-title":"Exp Mol Med"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"104339","DOI":"10.1016\/j.mvr.2022.104339","volume":"141","author":"Yousefabad A.S.L.","year":"2022","unstructured":"Yousefabad A.S.L.; Nammian P.; Tabei S.M.B.; Angiogenesis in diabetic mouse model with critical limb ischemia; cell and gene therapy. Microvasc Res  2022,141,104339","journal-title":"Microvasc Res"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"112","DOI":"10.5114\/fn.2018.76615","volume":"56","author":"Hu W.","year":"2018","unstructured":"Hu W.; Jiang J.; Yang F.; Liu J.; The impact of bone marrow-derived mesenchymal stem cells on neovascularisation in rats with brain injury. Folia Neuropathol  2018,56(2),112-123","journal-title":"Folia Neuropathol"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"1089","DOI":"10.3892\/ol.2015.3997","volume":"11","author":"Li G.C.","year":"2016","unstructured":"Li G.C.; Zhang H.W.; Zhao Q.C.; Mesenchymal stem cells promote tumor angiogenesis via the action of transforming growth factor \u03b21. Oncol Lett  2016,11(2),1089-1094","journal-title":"Oncol Lett"},{"key":"ref=33","first-page":"1023","volume":"11","author":"Ye L.","year":"2018","unstructured":"Ye L.; Peng Y.; Mo J.; Yao Y.; MiR-126 enhances VEGF expression in induced pluripotent stem cell-derived retinal neural stem cells by targeting spred-1. Int J Clin Exp Pathol  2018,11(2),1023-1030","journal-title":"Int J Clin Exp Pathol"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"106790","DOI":"10.18632\/oncotarget.22365","volume":"8","author":"Qu Q.","year":"2017","unstructured":"Qu Q.; Bing W.; Meng X.; Upregulation of miR-126-3p promotes human saphenous vein endothelial cell proliferation in vitro and prevents vein graft neointimal formation ex vivo and in vivo . Oncotarget  2017,8(63),106790-106806","journal-title":"Oncotarget"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"e002815","DOI":"10.1161\/JAHA.115.002815","volume":"5","author":"Tano N.","year":"2016","unstructured":"Tano N.; Kaneko M.; Ichihara Y.; Allogeneic mesenchymal stromal cells transplanted onto the heart surface achieve therapeutic myocardial repair despite immunologic responses in rats. J Am Heart Assoc  2016,5(2),e002815","journal-title":"J Am Heart Assoc"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s13287-019-1156-6","volume":"10","author":"Salda\u00f1a L.","year":"2019","unstructured":"Salda\u00f1a L.; Bensiamar F.; Vall\u00e9s G.; Mancebo F.J.; Rey G.E.; Vilaboa N.; Immunoregulatory potential of mesenchymal stem cells following activation by macrophage-derived soluble factors. Stem Cell Res Ther  2019,10(1),58","journal-title":"Stem Cell Res Ther"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"1191","DOI":"10.3389\/fimmu.2019.01191","volume":"10","author":"Weiss A.R.R.","year":"2019","unstructured":"Weiss A.R.R.; Dahlke M.H.; Immunomodulation by mesenchymal stem cells (MSCs): Mechanisms of action of living, apoptotic, and dead MSCs. Front Immunol  2019,10,1191","journal-title":"Front Immunol"},{"key":"ref=38","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s00277-015-2567-9","volume":"95","author":"Chen L.","year":"2016","unstructured":"Chen L.; Wang J.; Wang B.; MiR-126 inhibits vascular endothelial cell apoptosis through targeting PI3K\/Akt signaling. Ann Hematol  2016,95(3),365-374","journal-title":"Ann Hematol"},{"key":"ref=39","doi-asserted-by":"publisher","first-page":"10","DOI":"10.20517\/2347-8659.2018.01","volume":"5","author":"Qu M.J.","year":"2018","unstructured":"Qu M.J.; Pan J-J.; Shi X-J.; Zhang Z-J.; Tang Y-H.; Yang G-Y.; MicroRNA-126 is a prospective target for vascular disease. Neuroimmunol Neuroinflamm  2018,5(4),10","journal-title":"Neuroimmunol Neuroinflamm"}],"container-title":["MicroRNA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0122115366332247250124130611","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/239442\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0122115366332247250124130611","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T04:38:50Z","timestamp":1765427930000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/239442\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":39,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0122115366332247250124130611","relation":{},"ISSN":["2211-5366"],"issn-type":[{"value":"2211-5366","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Double blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2024-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-10","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}