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Silk fibroin (SF) possesses remarkable\nattributes, such as less immunogenicity, sterilization efficacy, processability without chemical\ncrosslinkers, excellent biocompatibility, low immunogenicity, non-toxicity, mechanical strength,\nthermal stability, non-carcinogenicity, and adjustable biodegradability make it a highly valuable\nbiomaterial. Silk fibroin hydrogel (SFH), a versatile biomaterial, has garnered significant attention\ndue to its unique properties. Its biocompatibility, tunable mechanical properties, water retention capacity,\nand bioactive nature offer a unique combination of features that can effectively promote tissue\nregeneration and enhance wound healing. The utilization of SF for hydrogel production presents\na valuable opportunity to leverage natural resources and promote eco-friendly production\npractices. With their exceptional properties and versatile applications in biomedicine, silk protein-\nbased hydrogels hold promise for various research fields. This review aims to discuss the potential\nproperties and recent advancements in the application of SF-based hydrogels for preclinical\nskin wound healing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0122117385339249241102165029","type":"journal-article","created":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T05:53:47Z","timestamp":1733896427000},"page":"484-508","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Silk Fibroin Hydrogels: Cutting-edge Developments and Future Directions"],"prefix":"10.2174","volume":"14","author":[{"given":"Govindaraj","family":"Sabarees","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Shri Venkateshwara College of Pharmacy, Ariyur, Puducherry 605102, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ganesan Padmini","family":"Tamilarasi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry, Shri Venkateshwara College of Pharmacy, Ariyur, Puducherry 605102, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayaraman","family":"Rajangam","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Shri Venkateshwara College of Pharmacy, Ariyur, Puducherry, 605102, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veerachamy","family":"Alagarsamy","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Research Laboratory, MNR College of Pharmacy, Greater Hyderabad, Sangareddy, 502294,\nIndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viswas Raja","family":"Solomon","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Research Laboratory, MNR College of Pharmacy, Greater Hyderabad, Sangareddy, 502294,\nIndia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1038\/s41598-021-03855-y","volume":"12","author":"Kuo T.Y.","year":"2022","unstructured":"Kuo T.Y.; Huang C.C.; Shieh S.J.; Wang Y.B.; Lin M.J.; Wu M.C.; Huang L.L.H.; Skin wound healing assessment via an optimized wound array model in miniature pigs. 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