{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T07:20:15Z","timestamp":1747207215418,"version":"3.40.5"},"reference-count":60,"publisher":"Bentham Science Publishers Ltd.","issue":"2","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["RADDF"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Probiotics must be able to withstand the demanding environment of the\ngastrointestinal system to adhere to the intestinal epithelium, promoting health benefits. The use of\nprobiotics can prevent or attenuate the effects of dysbiosis that have a deleterious effect on health,\npromoting anti-inflammatory, immunomodulatory, and antioxidant effects.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>The aim of the study was to prepare tablets containing Lactobacillus fermentum LF-G89\ncoated with 20% Acryl-Eze II\u00ae or Opadry\u00ae enteric polymers.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Tablet dissolution was evaluated under acidic and basic pH conditions, and aliquots of the\ndissolution medium were plated to count the Colony-forming Units (CFU). The free probiotic's tolerance\nto pH levels of 1.0, 2.0, 3.0, and 4.0, as well as to pepsin, pancreatin, and bile salts, was assessed.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The probiotic was released from tablets coated after they withstood the pH 1.2 acid stage\nfor 45 minutes. The release was higher with the Acry-Eze II\u00ae polymer in the basic stage. The\namount of CFU of free probiotics at pH 1.0 to 4.0 as well as pepsin reduced over time, indicating\ncell death. Conversely, the CFU over time with pancreatin and bile salts increased, demonstrating\nthe resistance of L. fermentum to these conditions due to hydrolases.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Both coating polymers were able to withstand the acid step, likely ensuring the release\nof the probiotic in the small intestine, promoting colonization. Coating with enteric material is a\nsimple and effective process to increase the survival of probiotics, offering a promising alternative\nto mitigate the negative effects of the dysbiosis process.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0126673878286133240418114629","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T10:58:45Z","timestamp":1714042725000},"page":"131-137","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<i>In Vitro<\/i> Development of Enteric-Coated Tablets of the Probiotic <i>Lactobacillus\nfermentum<\/i> LF-G89: A Possible Approach to Intestinal Colonization"],"prefix":"10.2174","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3601-5696","authenticated-orcid":true,"given":"Paola","family":"Sp\u00ednello","sequence":"first","affiliation":[{"name":"College of Pharmacy and Graduate Program in Human Aging, University of Passo Fundo, Passo Fundo\/ RS\/ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9523-3736","authenticated-orcid":true,"given":"Pamela","family":"do Nascimento","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Graduate Program in Human Aging, University of Passo Fundo, Passo Fundo\/ RS\/ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9923-5373","authenticated-orcid":true,"given":"Ver\u00f4nica Cristina","family":"da Silveira","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Graduate Program in Human Aging, University of Passo Fundo, Passo Fundo\/ RS\/ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7622-1916","authenticated-orcid":true,"given":"Tatiana","family":"Staudt","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Graduate Program in Human Aging, University of Passo Fundo, Passo Fundo\/ RS\/ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5637-8729","authenticated-orcid":true,"given":"Hamid","family":"Omidian","sequence":"additional","affiliation":[{"name":"College of Pharmacy, Nova Southeastern University, Fort Lauderdale, Florida, FL 33328, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9715-2283","authenticated-orcid":true,"given":"Ana Caroline","family":"Tissiani","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Graduate Program in Human Aging, University of Passo Fundo, Passo Fundo\/ RS\/ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7596-315X","authenticated-orcid":true,"given":"Charise Dallazem","family":"Bertol","sequence":"additional","affiliation":[{"name":"College of Pharmacy and Graduate Program in Human Aging, University of Passo Fundo, Passo Fundo\/ RS\/ Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","volume":"11","author":"Hill C.","year":"2014","unstructured":"Hill C.; Guarner F.; Reid G.; The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. 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