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Its development involves a combination of factors,\nincluding increased sebum production, changes in keratinization leading to comedone formation,\ncolonization of hair follicles by Propionibacterium acnes (P. acnes), and the release of inflammatory\nmediators in the vicinity of the pilosebaceous unit.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This review provides a concise overview of acne, covering its pathogenesis, epidemiology,\ndiagnosis, treatment options, and recent advancements involved in acne.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Discussion:<\/jats:title>\n<jats:p>Various therapeutic approaches, encompassing topical, systemic, combination, and\nhormonal treatments, are employed to address acne. Prolonged use of synthetic medications is\ncommon in acne therapy, but their potential for severe side effects prompts a preference for herbal-\nbased treatments. Herbal remedies utilizing extracts of natural origin are considered safer due\nto their lower toxicity and reduced likelihood of adverse drug reactions. Recent advancements, particularly\nin personalized medicine and microbiome research have enhanced our understanding and\nopened new avenues for more effective management.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Decoding acne vulgaris has provided insights into its pathogenesis, treatment modalities,\ndiagnostics, and recent advancements. Integrating synthetic and herbal treatments, personalized\nmedicine, microbiome research, and advanced modeling techniques offer promising acne management\nstrategies.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0127722708312980240718093537","type":"journal-article","created":{"date-parts":[[2024,7,29]],"date-time":"2024-07-29T08:07:47Z","timestamp":1722240467000},"page":"18-30","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Decoding Acne Vulgaris: Insights into Pathogenesis, Treatment Modalities, Diagnosis and Recent Advancements"],"prefix":"10.2174","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-0686-1110","authenticated-orcid":true,"given":"Priyanka","family":"Guleria","sequence":"first","affiliation":[{"name":"Department of Pharmaceutics, Laureate Institute of Pharmacy, VPO- Kathog, Kangra, H.P, 176031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4426-5251","authenticated-orcid":true,"given":"Shiana","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Laureate Institute of Pharmacy, VPO- Kathog, Kangra, H.P, 176031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1342-602X","authenticated-orcid":true,"given":"Shivika","family":"Parmar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Laureate Institute of Pharmacy, VPO- Kathog, Kangra, H.P, 176031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7212-086X","authenticated-orcid":true,"given":"Tarun","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Laureate Institute of Pharmacy, VPO- Kathog, Kangra, H.P, 176031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7218-6252","authenticated-orcid":true,"given":"Archana","family":"Chaudhary","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Laureate Institute of Pharmacy, VPO- Kathog, Kangra, H.P, 176031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9853-4489","authenticated-orcid":true,"given":"Pravin","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Laureate Institute of Pharmacy, VPO- Kathog, Kangra, H.P, 176031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7188-426X","authenticated-orcid":true,"given":"Mahendra Singh","family":"Ashawat","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, Laureate Institute of Pharmacy, VPO- Kathog, Kangra, H.P, 176031, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"105982","DOI":"10.1016\/j.micpath.2023.105982","volume":"175","author":"\u00d6zel \u015eahin G.","year":"2023","unstructured":"\u00d6zel \u015eahin G.; Toka \u00d6zer T.; Durmaz S.; Investigation of fungus at stratum corneum of patients with acne vulgaris. 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