{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:45:18Z","timestamp":1793148318868,"version":"4.5.0"},"reference-count":160,"publisher":"Bentham Science Publishers Ltd.","issue":"3","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRCEP"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction:<\/jats:title>\n                    <jats:p>Diabetic wounds are a prevalent and impairing consequence of diabetes\nmellitus that significantly impacts people's lives and global healthcare systems. Because of disturbances\nin the wound-healing cascade, these intricate, persistent wounds frequently refuse to heal.\nFocusing on diabetic wound formation, this study seeks to clarify the complex mechanisms and\npathophysiology involved while offering a thorough overview of modern multimodal therapy techniques.\nThe etiology of diabetic wounds entails a complex interplay between tissue destruction\ncaused by hyperglycemia, neuropathy, ischemia, and compromised immune response. Extended inflammation,\nabnormal protease activity, and low oxygen levels in the tissue exacerbate the healing\nprocess. Comprehending these pathogenic mechanisms is essential for formulating efficacious therapeutic\nstrategies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methodology:<\/jats:title>\n                    <jats:p>A thorough evaluation of the literature was done. Databases like SciFinder, ScienceDirect,\nPubMed, Google, Google Scholar, and the Egyptian Knowledge Bank were used to\nfind pertinent publications. More than 200 articles and databases were studied to constitute this\npaper. The accuracy of the retrieved data was carefully reviewed and cross-checked. The current\nreview aims to define wounds, various methods of classification, and various advancements for\nwound management. Several multidisciplinary strategies, including debridement, unloading, antimicrobial\nstewardship, and innovative therapeutics, are currently needed to manage diabetic\nwounds. Debridement\u2014the excision of non-viable tissue\u2014is necessary to create an environment\nthat is conducive to recovery. Biomechanical interventions and offloading help to prevent additional\ntissue damage caused by repetitive stress. Antimicrobial treatments fight infections, which are a\ncommon diabetic wound consequence. Promising supplementary treatments are provided by developments\nin cellular and tissue-based products, ozone therapy growth factors, bioengineered skin\nsubstitutes, and hyperbaric oxygen therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>After applying article selection criteria and reviewing the quality of the methodology a\ntotal of 200 articles were selected to be included in the review. In this review, intricate interactions\nbetween peripheral neuropathy, vascular insufficiency, and hyperglycemia in the pathophysiology\nof diabetic wounds are explained. The efficacy of multimodal therapies is discussed in detail.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion:<\/jats:title>\n                    <jats:p>A thorough comprehension of the complex mechanisms that underlie diabetic wounds\nis essential for efficient therapy. This review emphasizes how important multimodal approaches are\nto treating the complex pathophysiology of these wounds. Clinicians can greatly enhance the prognosis\nof patients with diabetic foot ulcers by addressing vascular insufficiency, neuropathy, infection,\nand poor healing.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>Timely wound resolution remains a key difficulty despite the implementation of multimodal\nmethods. To customize therapies, personalized medicine strategies utilizing genetic and\nproteomic biomarkers must be the main focus of future research. Furthermore, cutting-edge biotechnologies\nwith the potential to transform diabetic wound treatment include optogenetics and nanomedicine.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0127724328326480240927065600","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T05:53:43Z","timestamp":1729058023000},"page":"207-228","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Understanding Diabetic Wounds: A Review of Mechanisms, Pathophysiology, and Multimodal Management Strategies"],"prefix":"10.2174","volume":"20","author":[{"family":"Manisha","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Metro College of Health Sciences and Research, Greater Noida, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"family":"Niharika","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Metro College of Health Sciences and Research, Greater Noida, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen","family":"Gaur","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Metro College of Health Sciences and Research, Greater Noida, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radha","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of\nPharmacy, Lloyd Institute of Management Technology, Greater Noida, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanak","family":"Lata","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Metro College of Health Sciences and Research, Greater Noida, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosaline","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Metro College of Health Sciences and Research, Greater Noida, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","year":"2022","unstructured":"Encyclopedia Britannica  Available from:    https:\/\/www. britannica.com\/science\/wound Accessed 29 February 2024.2022"},{"key":"ref=2","first-page":"239","volume":"105","author":"Kujath P.","year":"2008","unstructured":"Kujath P.; Michelsen A.; Wounds - From physiology to wound dressing. 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