{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T11:10:49Z","timestamp":1778843449383,"version":"3.51.4"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CRCEP"],"published-print":{"date-parts":[[2026,5,13]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract:<\/jats:title>\n                    <jats:p>Almost immediately after the discovery of opioid peptides and opioid receptors (ORs),\nreports were published that some effects of opioid peptides are independent of the activation of\nORs. It was demonstrated that Des-Tyr1-fragments of opioid peptides did not interact with ORs but\ncan exert different effects both in vivo and in vivo. They modify the functional state of the brain, the\nheart, the trachea, the aorta, arteries, natural killers, neutrophils, lymphocytes, and adrenal glands. It\nis quite obvious that non-ORs of Des-Tyr1-enkephalins, Des-Tyr1-dynorphins A, \u03b2-endorphin (2-\n17), and \u03b2-endorphin (12-19) can be different. The physiological role of non-ORs of opioid peptides\nremains unknown because non-OR antagonists have not yet been found. It is unclear which Gproteins\nare coupled to non-ORs. It is unknown which intracellular messengers are involved in the\neffects of the activation of non-ORs by opioid peptides.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0127724328447479260426103254","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:47:42Z","timestamp":1778842062000},"update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Opioid Receptor Independent Effects of Opioid Peptides"],"prefix":"10.2174","volume":"21","author":[{"given":"Leonid N","family":"Maslov","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander V","family":"Mukhomedzyanov","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center,Russian Academy of Sciences, Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisa S","family":"Slidnevskaya","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander S","family":"Gorbunov","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey V","family":"Popov","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center,Russian Academy of Sciences, Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"Kan","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center,Russian Academy of Sciences, Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia V","family":"Naryzhnaya","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Cardiology, Cardiology Research Institute, Tomsk National Research Medical Center, Russian Academy of Sciences, Tomsk, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pathophysiology, Airforce Medical University, Xi'an, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philipp A","family":"Ilinykh","sequence":"additional","affiliation":[{"name":"Laboratory of Antibody Discovery and Accelerated Protein Therapeutics, Center for Infectious Diseases, Houston Methodist Research Institute and Department of Pathology and Genomic Medicine, Houston MethodistHospital, Houston, TX, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viacheslav N","family":"Azev","sequence":"additional","affiliation":[{"name":"The Branch of the Institute of Bioorganic Chemistry, Russian Academy of Sciences, Pushchino, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huijie","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Physiology, Hebei Medical University, Shijiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","container-title":["Current Reviews in Clinical and Experimental Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0127724328447479260426103254","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/253974\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0127724328447479260426103254","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T10:48:00Z","timestamp":1778842080000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/253974\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,13]]},"references-count":0,"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0127724328447479260426103254","relation":{},"ISSN":["2772-4328"],"issn-type":[{"value":"2772-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5,13]]},"assertion":[{"value":"Peer 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