{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T04:07:28Z","timestamp":1743221248407,"version":"3.40.3"},"reference-count":19,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["RAAIDD"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec>\n<jats:title>Introduction:<\/jats:title>\n<jats:p>Recent research has been concentrated on investigating the\ninvolvement of Toxoplasma gondii (T. gondii) in the progression of liver disorders.\nThis study aims to investigate the prevalence of T. gondii infection in patients with\nnon-alcoholic fatty liver disease (NAFLD), as well as the effects of toxoplasmosis infection\non biological biomarkers such as aspirate transaminase (AST), alanine transaminase\n(ALT), cholesterol (Chol), and triglyceride (Tg) levels in Sistan, southeast Iran.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>A case-control study was conducted between December 2021 and September\n2022. The study included 225 patients diagnosed with NAFLD as the case group\nand 225 healthy blood donors as the control group. The controls were selected from\nthe same region and were matched with the patients based on gender and age. We collected\nserum samples from all patients and utilized an enzyme-linked immunosorbent\nassay to analyze them for the existence of anti-T. gondii IgG antibodies. A questionnaire\nand medical records were utilized to gather data on the patient's demographic\nfactors.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The prevalence of anti-T. gondii IgG antibodies were 68 (30.2%) in patients\nwith NAFLD, whereas it was 11 (4.88%) in the control group. The seroprevalence of\nT. gondii in NAFLD patients increased in correlation with age (P &lt; 0.001). The prevalence\nof NAFLD was significantly greater in the seropositive group compared to the\nseronegative group (P &lt; 0.001). In addition, the levels of the metabolic markers Chol\nand Tg were significantly higher in T. gondii seropositive NAFLD patients compared\nto T. gondii seronegative NAFLD patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>The findings of this study indicate a high seroprevalence of T. gondii in\npatients with NAFLD. Further studies are warranted to investigate the underlying\nmechanisms and potential therapeutic implications of this association.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0127724344286367240221082018","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T11:35:06Z","timestamp":1709638506000},"page":"30-36","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Seroepidemiology of Toxoplasma gondii Infection in Patients with Liver Disease in Southeastern Iran"],"prefix":"10.2174","volume":"20","author":[{"given":"Atefeh","family":"Oveisipour","sequence":"first","affiliation":[{"name":"Department of Parasitology and Mycology, School of Medicine Zabol University of Medical Sciences,\nZabol, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9094-5424","authenticated-orcid":true,"given":"Maryam","family":"Hataminejad","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology, School of Medicine, Mazandaran University of Medical\nSciences, Sari, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9848-6242","authenticated-orcid":true,"given":"Bahman","family":"Fouladi","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Mycology, School of Medicine Zabol University of Medical Sciences,\nZabol, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1095-1806","authenticated-orcid":true,"given":"Hakim","family":"Azizi","sequence":"additional","affiliation":[{"name":"Department of Parasitology and Mycology, School of Medicine Zabol University of Medical Sciences,\nZabol, Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.chom.2015.09.006","volume":"18","author":"Foe I.T.","year":"2015","unstructured":"Foe I.T.; Child M.A.; Majmudar J.D.; Global analysis of palmitoylated proteins in Toxoplasma gondii. 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