{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T04:46:25Z","timestamp":1751517985104,"version":"3.37.3"},"reference-count":56,"publisher":"Bentham Science Publishers Ltd.","issue":"7","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["PPL"],"published-print":{"date-parts":[[2019,7,22]]},"abstract":"<jats:sec><jats:title>Background:<\/jats:title><jats:p>Angiotensin Converting Enzyme (ACE) 2 is an important modulator of the Renin Angiotensin System (RAS) and the RAS plays a central role in renovascular hypertension. Very few studies investigated the role of components of the counterregulatory RAS axis (ACE2, Ang-(1-7) and Mas receptor) in renovascular hypertension and the results are controversial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective:<\/jats:title><jats:p>The aim of this study was to investigate the effects of Diminazene Aceturate (DIZE) administration on renal function and renal inflammation parameters in 2K1C hypertensive rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods:<\/jats:title><jats:p>Male Wistar rats were divided into three experimental groups: sham-operated animals, 2K1C+saline and 2K1C+DIZE orally (1 mg\/kg\/day). At the end of the 30 days of treatment, renal function was analyzed and kidneys from all the groups were collected and processed separately for measurement of N-acetyl-beta-D-glucosaminidase (NAG) and Myeloperoxidase (MPO) activities, cytokines, chemokines and nitric oxide levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results:<\/jats:title><jats:p>Oral DIZE administration for 4 weeks in hypertensive rats attenuated renal dysfunction and reduced the levels of MPO and NAG, cytokines and chemokines (IL1\u03b2, IL-6, TNF-\u03b1 and MCP-1) and increased urinary nitrate\/nitrite levels in 2K1C hypertensive rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion:<\/jats:title><jats:p>Our findings showed that ACE2 activation may effectively improve renal alterations and inflammation induced by renovascular hypertension.<\/jats:p><\/jats:sec>","DOI":"10.2174\/0929866526666190405123422","type":"journal-article","created":{"date-parts":[[2019,4,5]],"date-time":"2019-04-05T12:23:43Z","timestamp":1554467023000},"page":"523-531","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Beneficial Effects of the Angiotensin-Converting Enzyme 2 Activator Dize in Renovascular Hypertension"],"prefix":"10.2174","volume":"26","author":[{"given":"Lucas Miranda","family":"Kangussu","sequence":"first","affiliation":[{"name":"Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiane Cristine S.","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Ruiz R.","family":"Prestes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilda Luz","family":"de Andrade De Maria","sequence":"additional","affiliation":[{"name":"Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"da Silva Filha","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Aparecida Ribeiro","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cristina Sim\u00f5es e","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, School of Medicine, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson Jos\u00e9","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Department of Morphology, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/JOE-12-0341","volume":"216","author":"Santos R.A.","year":"2013","unstructured":"Santos RA. J Endocrinol, Ferreira, A.J.; Verano-Braga, T.; Bader M. Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: New players of the renin-angiotensin system.,, 2013, 216,, 1-17,[http:\/\/dx.doi.org\/10.1530\/JOE-12-0341].","journal-title":"J Endocrinol"},{"key":"ref=2","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0001-2998(89)80003-0","volume":"19","author":"Pickering T.G.","year":"1989","unstructured":"Pickering TG. Semin Nucl Med, Renovascular hypertension: etiology and pathophysiology.,, 1989, 19,, 79-88,[http:\/\/dx.doi.org\/10.1016\/S0001-2998(89)80003-0]. [PMID: 2652313].","journal-title":"Semin Nucl Med"},{"key":"ref=3","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1152\/physrev.1990.70.4.1067","volume":"70","author":"Hackenthal E.","year":"1990","unstructured":"Hackenthal E, Paul M, Ganten D, Taugner R. Physiol Rev, Morphology, physiology, and molecular biology of renin secretion.,, 1990, 70,, 1067-1116,[http:\/\/dx.doi.org\/10.1152\/physrev.1990.70.4.1067]. [PMID: 2217555].","journal-title":"Physiol Rev"},{"key":"ref=4","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1038\/ki.1994.446","volume":"46","author":"Deschepper C.F.","year":"1994","unstructured":"Deschepper CF. Kidney Int, Angiotensinogen: Hormonal regulation and relative importance in the generation of angiotensin II.,, 1994, 46,, 1561-1563,[http:\/\/dx.doi.org\/10.1038\/ki.1994.446]. [PMID: 7700006].","journal-title":"Kidney Int"},{"key":"ref=5","doi-asserted-by":"crossref","first-page":"9","DOI":"10.18553\/jmcp.2007.13.s8-b.9","volume":"13","author":"Atlas S.A.","year":"2007","unstructured":"Atlas SA. J Manag Care Pharm, The renin-angiotensin aldosterone system: Pathophysiological role and pharmacologic inhibition.,, 2007, 13,, 9-20,[http:\/\/dx.doi.org\/10.18553\/jmcp.2007.13.s8-b.9]. [PMID: 17970613].","journal-title":"J Manag Care Pharm"},{"key":"ref=6","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1080\/08037050310001057","volume":"12","author":"Kaschina E.","year":"2003","unstructured":"Kaschina E, Unger T. Blood Press, Angiotensin AT1\/AT2 receptors: Regulation, signalling and function.,, 2003, 12,, 70-88,[http:\/\/dx.doi.org\/10.1080\/08037050310001057]. [PMID: 12797627].","journal-title":"Blood Press"},{"key":"ref=7","doi-asserted-by":"crossref","first-page":"17985","DOI":"10.1073\/pnas.0605545103","volume":"103","author":"Crowley S.D.","year":"2006","unstructured":"Crowley SD, Gurley SB, Herrera MJ, Ruiz P, Griffiths R, Kumar AP, Kim HS, Smithies O, Le TH, Coffman TM. Proc Natl Acad Sci USA, Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney.,, 2006, 103,, 17985-17990,[http:\/\/dx.doi.org\/10.1073\/pnas.0605545103]. [PMID: 17090678].","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=8","doi-asserted-by":"crossref","first-page":"R438","DOI":"10.1152\/ajpregu.00590.2007","volume":"294","author":"Bivol L.M.","year":"2008","unstructured":"Bivol LM, Berge RK, Iversen BM. Am J Physiol Regul Integr Comp Physiol, Tetradecylthioacetic acid prevents the inflammatory response in two-kidney, one-clip hypertension.,, 2008, 294,, R438-R447,[http:\/\/dx.doi.org\/10.1152\/ajpregu.00590.2007]. [PMID: 18032469].","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"ref=9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.semnephrol.2003.11.008","volume":"24","author":"Agarwal R.","year":"2004","unstructured":"Agarwal R, Campbell RC, Warnock DG. Semin Nephrol, Oxidative stress in hypertension and chronic kidney disease: Role of angiotensin II.,, 2004, 24,, 101-114,[http:\/\/dx.doi.org\/10.1016\/j.semnephrol.2003.11.008]. [PMID: 15017522].","journal-title":"Semin Nephrol"},{"key":"ref=10","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1161\/01.CIR.0000039528.49161.E9","volume":"106","author":"Minuz P.","year":"2002","unstructured":"Minuz P, Patrignani P, Gaino S, Degan M, Menapace L, Tommasoli R, Seta F, Capone ML, Tacconelli S, Palatresi S, Bencini C, Del Vecchio C, Mansueto G, Arosio E, Santonastaso CL, Lechi A, Morganti A, Patrono C. Circulation, Increased oxidative stress and platelet activation in patients with hypertension and renovascular disease.,, 2002, 106,, 2800-2805,[http:\/\/dx.doi.org\/10.1161\/01.CIR.0000039528.49161.E9]. [PMID: 12451006].","journal-title":"Circulation"},{"key":"ref=11","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1089\/ars.2013.5302","volume":"20","author":"Montezano A.C.","year":"2014","unstructured":"Montezano AC, Touyz RM. Antioxid Redox Signal, Reactive oxygen species, vascular Noxs, and hypertension: Focus on translational and clinical research.,, 2014, 20,, 164-182,[http:\/\/dx.doi.org\/10.1089\/ars.2013.5302]. [PMID: 23600794].","journal-title":"Antioxid Redox Signal"},{"key":"ref=12","first-page":"170","volume":"13","author":"Navar L.G.","year":"1998","unstructured":"Navar LG, Zou L, Von Thun A, Tarng Wang C, Imig JD, Mitchell KD. News Physiol Sci, Unraveling the mystery of Goldblatt hypertension.,, 1998, 13,, 170-176,[PMID: 11390784].","journal-title":"News Physiol Sci"},{"key":"ref=13","doi-asserted-by":"crossref","first-page":"33238","DOI":"10.1074\/jbc.M002615200","volume":"275","author":"Tipnis S.R.","year":"2000","unstructured":"Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G, Turner AJ. J Biol Chem, A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase.,, 2000, 275,, 33238-33243,[http:\/\/dx.doi.org\/10.1074\/jbc.M002615200]. [PMID: 10924499].","journal-title":"J Biol Chem"},{"key":"ref=14","doi-asserted-by":"crossref","first-page":"E1","DOI":"10.1161\/01.RES.87.5.e1","volume":"87","author":"Donoghue M.","year":"2000","unstructured":"Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, Donovan M, Woolf B, Robison K, Jeyaseelan R, Breitbart RE, Acton S. Circ Res, A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9.,, 2000, 87,, E1-E9,[http:\/\/dx.doi.org\/10.1161\/01.RES.87.5.e1]. [PMID: 10969042].","journal-title":"Circ Res"},{"key":"ref=15","doi-asserted-by":"crossref","first-page":"8258","DOI":"10.1073\/pnas.1432869100","volume":"100","author":"Santos R.A.","year":"2003","unstructured":"Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, Heringer-Walther S, Pinheiro SV, Lopes MT, Bader M, Mendes EP, Lemos VS, Campagnole-Santos MJ, Schultheiss HP, Speth R, Walther T. Proc Natl Acad Sci USA, Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas.,, 2003, 100,, 8258-8263,[http:\/\/dx.doi.org\/10.1073\/pnas.1432869100]. [PMID: 12829792].","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=16","doi-asserted-by":"crossref","first-page":"1988","DOI":"10.1097\/HJH.0b013e32832f0d06","volume":"27","author":"B\u00fcrgelov\u00e1 M.","year":"2009","unstructured":"B\u00fcrgelov\u00e1 M, Vanourkov\u00e1 Z, Thumov\u00e1 M, Dvor\u00e1k P, Opocensk\u00fd M, Kramer HJ, Zel\u00edzko M, Mal\u00fd J, Bader M, Cervenka L. J Hypertens, Impairment of the angiotensin-converting enzyme 2-angiotensin-(1-7)-Mas axis contributes to the acceleration of two-kidney, one-clip Goldblatt hypertension.,, 2009, 27,, 1988-2000,[http:\/\/dx.doi.org\/10.1097\/HJH.0b013e32832f0d06]. [PMID: 19593210].","journal-title":"J Hypertens"},{"key":"ref=17","doi-asserted-by":"crossref","first-page":"H2372","DOI":"10.1152\/ajpheart.00846.2011","volume":"302","author":"Shah A.","year":"2012","unstructured":"Shah A, Oh YB, Lee SH, Lim JM, Kim SH. Am J Physiol Heart Circ Physiol, Angiotensin-(1-7) attenuates hypertension in exercise-trained renal hypertensive rats.,, 2012, 302,, H2372-H2380,[http:\/\/dx.doi.org\/10.1152\/ajpheart.00846.2011]. [PMID: 22467306].","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref=18","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1159\/000320689","volume":"33","author":"Raku\u0161an D.","year":"2010","unstructured":"Raku\u0161an D, B\u00fcrgelov\u00e1 M, Van\u011b\u010dkov\u00e1 I, Va\u0148ourkov\u00e1 Z, Huskov\u00e1 Z, Skaroupkov\u00e1 P, Mr\u00e1zov\u00e1 I, Opo\u010densk\u00fd M, Kramer HJ, Netuka I, Mal\u00fd J, Alenina N, Bader M, Santos RA, Cervenka L. Kidney Blood Press Res, Knockout of angiotensin 1-7 receptor Mas worsens the course of two-kidney, one-clip Goldblatt hypertension: Roles of nitric oxide deficiency and enhanced vascular responsiveness to angiotensin II.,, 2010, 33,, 476-488,[http:\/\/dx.doi.org\/10.1159\/000320689]. [PMID: 21071955].","journal-title":"Kidney Blood Press Res"},{"key":"ref=19","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1161\/HYPERTENSIONAHA.113.01337","volume":"62","author":"Qi Y.","year":"2013","unstructured":"Qi Y, Zhang J, Cole-Jeffrey CT, Shenoy V, Espejo A, Hanna M, Song C, Pepine CJ, Katovich MJ, Raizada MK. Hypertension, Diminazene aceturate enhances angiotensin-converting enzyme 2 activity and attenuates ischemia-induced cardiac pathophysiology.,, 2013, 62,, 746-752,[http:\/\/dx.doi.org\/10.1161\/HYPERTENSIONAHA.113.01337]. [PMID: 23959549].","journal-title":"Hypertension"},{"key":"ref=20","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2174\/0929866522666151013130550","volume":"23","author":"De Maria M.L.","year":"2016","unstructured":"De Maria ML, Ara\u00fajo LD, Fraga-Silva RA, Pereira LA, Ribeiro HJ, Menezes GB, Shenoy V, Raizada MK, Ferreira AJ. Protein Pept Lett, Anti-hypertensive effects of diminazene aceturate: An angiotensin-converting enzyme 2 activator in rats.,, 2016, 23,, 9-16,[http:\/\/dx.doi.org\/10.2174\/0929866522666151013130550]. [PMID: 26458404].","journal-title":"Protein Pept Lett"},{"key":"ref=21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0118758","volume":"10","author":"Velkoska E.","year":"2015","unstructured":"Velkoska E, Patel SK, Griggs K, Pickering RJ, Tikellis C, Burrell LM. PLoS One, Short-term treatment with diminazene aceturate ameliorates the reduction in kidney ACE2 activity in rats with subtotal nephrectomy.,, 2015, 10,, 9-,[http:\/\/dx.doi.org\/10.1371\/journal.pone.0118758]. [PMID: 25786223].","journal-title":"PLoS One"},{"key":"ref=22","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1113\/expphysiol.2011.058578","volume":"96","author":"Mecca A.P.","year":"2011","unstructured":"Mecca AP, Regenhardt RW, O\u2019Connor TE, Joseph JP, Raizada MK, Katovich MJ, Sumners C. Exp Physiol, Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke.,, 2011, 96,, 1084-1096,[http:\/\/dx.doi.org\/10.1113\/expphysiol.2011.058578]. [PMID: 21685445].","journal-title":"Exp Physiol"},{"key":"ref=23","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1167\/iovs.14-13883","volume":"55","author":"Qiu Y.","year":"2014","unstructured":"Qiu Y, Shil PK, Zhu P, Yang H, Verma A, Lei B, Li Q. Invest Ophthalmol Vis Sci, Angiotensin-converting enzyme 2 (ACE2) activator diminazene aceturate ameliorates endotoxin-induced uveitis in mice.,, 2014, 55,, 3809-3818,[http:\/\/dx.doi.org\/10.1167\/iovs.14-13883]. [PMID: 24854854].","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref=24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1084\/jem.59.3.347","volume":"59","author":"Goldblatt H.","year":"1934","unstructured":"Goldblatt H, Lynch J, Hanzal RF, Summerville WW. J Exp Med, Studies on experimental hypertension: The production of persistent elevation of systolic blood pressure by means of renal ischemia.,, 1934, 59,, 347-379,[http:\/\/dx.doi.org\/10.1084\/jem.59.3.347]. [PMID: 19870251].","journal-title":"J Exp Med"},{"key":"ref=25","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1161\/01.HYP.33.1.102","volume":"33","author":"Cervenka L.","year":"1999","unstructured":"Cervenka L, Wang CT, Mitchell KD, Navar LG. Hypertension, Proximal tubular angiotensin II levels and renal functional responses to AT1 receptor blockade in nonclipped kidneys of Goldblatt hypertensive rats.,, 1999, 33,, 102-107,[http:\/\/dx.doi.org\/10.1161\/01.HYP.33.1.102]. [PMID: 9931089].","journal-title":"Hypertension"},{"key":"ref=26","doi-asserted-by":"crossref","first-page":"F841","DOI":"10.1152\/ajprenal.2000.279.5.F841","volume":"279","author":"Allred A.J.","year":"2000","unstructured":"Allred AJ, Diz DI, Ferrario CM, Chappell MC. Am J Physiol Renal Physiol, Pathways for angiotensin-(1-7) metabolism in pulmonary and renal tissues.,, 2000, 279,, F841-F850,[http:\/\/dx.doi.org\/10.1152\/ajprenal.2000.279.5.F841]. [PMID: 11053044].","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref=27","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1097\/00041552-200401000-00015","volume":"13","author":"Navar L.G.","year":"2004","unstructured":"Navar LG, Nishiyama A. Curr Opin Nephrol Hypertens, Why are angiotensin concentrations so high in the kidney?,, 2004, 13,, 107-115,[http:\/\/dx.doi.org\/10.1097\/00041552-200401000-00015]. [PMID: 15090867].","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"ref=28","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1111\/j.1523-1755.2005.00670.x","volume":"68","author":"Jaimes E.A.","year":"2005","unstructured":"Jaimes EA, Tian RX, Pearse D, Raij L. Kidney Int, Up-regulation of glomerular COX-2 by angiotensin II: Role of reactive oxygen species.,, 2005, 68,, 2143-2153,[http:\/\/dx.doi.org\/10.1111\/j.1523-1755.2005.00670.x]. [PMID: 16221213].","journal-title":"Kidney Int"},{"key":"ref=29","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1161\/hy0302.104673","volume":"39","author":"Ren Y.","year":"2002","unstructured":"Ren Y, Garvin JL, Carretero OA. Hypertension, Vasodilator action of angiotensin-(1-7) on isolated rabbit afferent arterioles.,, 2002, 39,, 799-802,[http:\/\/dx.doi.org\/10.1161\/hy0302.104673]. [PMID: 11897767].","journal-title":"Hypertension"},{"key":"ref=30","doi-asserted-by":"crossref","first-page":"H1985","DOI":"10.1152\/ajpheart.01145.2002","volume":"284","author":"Sampaio W.O.","year":"2003","unstructured":"Sampaio WO, Nascimento AA, Santos RA. Am J Physiol Heart Circ Physiol, Systemic and regional hemodynamic effects of angiotensin-(1-7) in rats.,, 2003, 284,, H1985-H1994,[http:\/\/dx.doi.org\/10.1152\/ajpheart.01145.2002]. [PMID: 12573992].","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref=31","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.cardiores.2003.11.017","volume":"61","author":"Stegbauer J.","year":"2004","unstructured":"Stegbauer J, Oberhauser V, Vonend O, Rump LC. Cardiovasc Res, Angiotensin-(1-7) modulates vascular resistance and sympathetic neurotransmission in kidneys of spontaneously hypertensive rats.,, 2004, 61,, 352-359,[http:\/\/dx.doi.org\/10.1016\/j.cardiores.2003.11.017]. [PMID: 14736552].","journal-title":"Cardiovasc Res"},{"key":"ref=32","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1038\/ki.2009.61","volume":"75","author":"Pinheiro S.V.B.","year":"2009","unstructured":"Pinheiro SVB, Ferreira AJ, Kitten GT, da Silveira KD, da Silva DA, Santos SHS, Gava E, Castro CH, Magalh\u00e3es JA, da Mota RK, Botelho-Santos GA, Bader M, Alenina N, Santos RAS, Simoes E, Silva AC. Kidney Int, Genetic deletion of the angiotensin-(1-7) receptor Mas leads to glomerular hyperfiltration and microalbuminuria.,, 2009, 75,, 1184-1193,[http:\/\/dx.doi.org\/10.1038\/ki.2009.61]. [PMID: 19262461].","journal-title":"Kidney Int"},{"key":"ref=33","volume":"8","author":"Silveira K.D.","year":"2013","unstructured":"Silveira KD, Barroso LC, Vieira AT, Cisalpino D, Lima CX, Bader M, Arantes RM, Dos Santos RA, Sim\u00f5es-E-Silva AC, Teixeira MM. PLoS One, Beneficial effects of the activation of the angiotensin-(1-7) MAS receptor in a murine model of adriamycin-induced nephropathy.,, 2013, 8,, 1184-,[http:\/\/dx.doi.org\/10.1371\/journal.pone.0066082]. [PMID: 23762470].","journal-title":"PLoS One"},{"key":"ref=34","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/808726","volume":"2012","author":"Barroso L.C.","year":"2012","unstructured":"Barroso LC, Silveira KD, Lima CX, Borges V, Bader M, Rachid M, Santos RA, Souza DG, Sim\u00f5es E. Int J Hypertens, Silva, A.C.; Teixeira, M.M. Renoprotective effects of AVE0991, a nonpeptide mass receptor agonist, in experimental acute renal injury.,, 2012, 2012,, 1184-,[http:\/\/dx.doi.org\/10.1155\/2012\/808726]. [PMID: 22319645].","journal-title":"Int J Hypertens"},{"key":"ref=35","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/hr.2009.25","volume":"32","author":"Li Y.","year":"2009","unstructured":"Li Y, Wu J, He Q, Shou Z, Zhang P, Pen W, Zhu Y, Chen J. Hypertens Res, Angiotensin (1-7) prevent heart dysfunction and left ventricular remodeling caused by renal dysfunction in 5\/6 nephrectomy mice.,, 2009, 32,, 369-374,[http:\/\/dx.doi.org\/10.1038\/hr.2009.25]. [PMID: 19325560].","journal-title":"Hypertens Res"},{"key":"ref=36","doi-asserted-by":"crossref","first-page":"F1523","DOI":"10.1152\/ajprenal.00426.2009","volume":"298","author":"Dilauro M.","year":"2010","unstructured":"Dilauro M, Zimpelmann J, Robertson SJ, Genest D, Burns KD. Am J Physiol Renal Physiol, Effect of ACE2 and angiotensin-(1-7) in a mouse model of early chronic kidney disease.,, 2010, 298,, F1523-F1532,[http:\/\/dx.doi.org\/10.1152\/ajprenal.00426.2009]. [PMID: 20357030].","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref=37","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.2353\/ajpath.2006.051091","volume":"168","author":"Oudit G.Y.","year":"2006","unstructured":"Oudit GY, Herzenberg AM, Kassiri Z, Wong D, Reich H, Khokha R, Crackower MA, Backx PH, Penninger JM, Scholey JW. Am J Pathol, Loss of angiotensin-converting enzyme-2 leads to the late development of angiotensin II-dependent glomerulosclerosis.,, 2006, 168,, 1808-1820,[http:\/\/dx.doi.org\/10.2353\/ajpath.2006.051091]. [PMID: 16723697].","journal-title":"Am J Pathol"},{"key":"ref=38","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1038\/sj.ki.5002373","volume":"72","author":"Soler M.J.","year":"2007","unstructured":"Soler MJ, Wysocki J, Ye M, Lloveras J, Kanwar Y, Batlle D. 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J Am Soc Nephrol, Glomerular localization and expression of Angiotensin-converting enzyme 2 and Angiotensin-converting enzyme: implications for albuminuria in diabetes.,, 2006, 17,, 3067-3075,[http:\/\/dx.doi.org\/10.1681\/ASN.2006050423]. [PMID: 17021266].","journal-title":"J Am Soc Nephrol"},{"key":"ref=41","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1042\/CS20090554","volume":"119","author":"da Silveira K.D.","year":"2010","unstructured":"da Silveira KD, Pompermayer Bosco KS, Diniz LR, Carmona AK, Cassali GD, Bruna-Romero O, de Sousa LP, Teixeira MM, Santos RA, Sim\u00f5es e Silva AC, Ribeiro Vieira MA. Clin Sci (Lond), ACE2-angiotensin-(1-7)-Mas axis in renal ischaemia\/reperfusion injury in rats.,, 2010, 119,, 385-394,[http:\/\/dx.doi.org\/10.1042\/CS20090554]. [PMID: 20528771].","journal-title":"Clin Sci (Lond)"},{"key":"ref=42","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.regpep.2005.02.014","volume":"129","author":"Lara L.S.","year":"2005","unstructured":"Lara LS, De Carvalho T, Le\u00e3o-Ferreira LR, Lopes AG, Caruso-Neves C. Regul Pept, Modulation of the (Na(+)+K+)ATPase activity by Angiotensin-(1-7) in MDCK cells.,, 2005, 129,, 221-226,[http:\/\/dx.doi.org\/10.1016\/j.regpep.2005.02.014]. [PMID: 15927719].","journal-title":"Regul Pept"},{"key":"ref=43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1476-5381.1994.tb14014.x","volume":"111","author":"","year":"1994","unstructured":". Br J Pharmacol, DelliPizzi, A.M.; Hilchey, S.D.; Bell-Quilley, C.P. Natriuretic action of angiotensin (1-7).,, 1994, 111,, 1-3,[http:\/\/dx.doi.org\/10.1111\/j.1476-5381.1994.tb14014.x]. [PMID: 8012686].","journal-title":"Br J Pharmacol"},{"key":"ref=44","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1159\/000174151","volume":"20","author":"Vallon V.","year":"1997","unstructured":"Vallon V, Richter K, Heyne N, Osswald H. Kidney Blood Press Res, Effect of intratubular application of angiotensin 1-7 on nephron function.,, 1997, 20,, 233-239,[http:\/\/dx.doi.org\/10.1159\/000174151]. [PMID: 9398028].","journal-title":"Kidney Blood Press Res"},{"key":"ref=45","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000066340","volume":"25","author":"B\u00fcrgelov\u00e1 M.","year":"2002","unstructured":"B\u00fcrgelov\u00e1 M, Kramer HJ, Teplan V, Velickov\u00e1 G, V\u00edtko S, Heller J, Mal\u00fd J, Cervenka L. Kidney Blood Press Res, Intrarenal infusion of angiotensin-(1-7) modulates renal functional responses to exogenous angiotensin II in the rat.,, 2002, 25,, 202-210,[http:\/\/dx.doi.org\/10.1159\/000066340]. [PMID: 12424421].","journal-title":"Kidney Blood Press Res"},{"key":"ref=46","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1161\/01.HYP.27.4.875","volume":"27","author":"Santos R.A.","year":"1996","unstructured":"Santos RA, Sim\u00f5es e Silva AC, Magaldi AJ, Khosla MC, Cesar KR, Passaglio KT, Baracho NC. Hypertension, Evidence for a physiological role of angiotensin-(1-7) in the control of hydroelectrolyte balance.,, 1996, 27,, 875-884,[http:\/\/dx.doi.org\/10.1161\/01.HYP.27.4.875]. [PMID: 8613263].","journal-title":"Hypertension"},{"key":"ref=47","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0167-0115(98)00038-X","volume":"74","author":"Sim\u00f5es e Silva A.C.","year":"1998","unstructured":"Sim\u00f5es e Silva AC, Bello AP, Baracho NC, Khosla MC, Santos RA. Regul Pept, Diuresis and natriuresis produced by long term administration of a selective Angiotensin-(1-7) antagonist in normotensive and hypertensive rats.,, 1998, 74,, 177-184,[http:\/\/dx.doi.org\/10.1016\/S0167-0115(98)00038-X]. [PMID: 9712179].","journal-title":"Regul Pept"},{"key":"ref=48","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s00424-003-1173-1","volume":"447","author":"Magaldi A.J.","year":"2003","unstructured":"Magaldi AJ, Cesar KR, de Ara\u00fajo M, Sim\u00f5es e Silva AC, Santos RA. Pflugers Arch, Angiotensin-(1-7) stimulates water transport in rat inner medullary collecting duct: Evidence for involvement of vasopressin V2 receptors.,, 2003, 447,, 223-230,[http:\/\/dx.doi.org\/10.1007\/s00424-003-1173-1]. [PMID: 14534790].","journal-title":"Pflugers Arch"},{"key":"ref=49","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1161\/01.HYP.0000141438.64887.42","volume":"44","author":"Pinheiro S.V.","year":"2004","unstructured":"Pinheiro SV, Sim\u00f5es e Silva AC, Sampaio WO, de Paula RD, Mendes EP, Bontempo ED, Pesquero JB, Walther T, Alenina N, Bader M, Bleich M, Santos RA. Hypertension, Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney.,, 2004, 44,, 490-496,[http:\/\/dx.doi.org\/10.1161\/01.HYP.0000141438.64887.42]. [PMID: 15326087].","journal-title":"Hypertension"},{"key":"ref=50","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1590\/S0100-879X1998000900016","volume":"31","author":"Baracho N.C.","year":"1998","unstructured":"Baracho NC, Sim\u00f5es-e-Silva AC, Khosla MC, Santos RA. Braz J Med Biol Res, Effect of selective angiotensin antagonists on the antidiuresis produced by angiotensin-(1-7) in water-loaded rats.,, 1998, 31,, 1221-1227,[http:\/\/dx.doi.org\/10.1590\/S0100-879X1998000900016]. [PMID: 9876290].","journal-title":"Braz J Med Biol Res"},{"key":"ref=51","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1590\/S0101-28002011000300012","volume":"33","author":"Vianna H.R.","year":"2011","unstructured":"Vianna HR, Soares CM, Tavares MS, Teixeira MM, Silva AC. J Bras Nefrol, Inflammation in chronic kidney disease: the role of cytokines.,, 2011, 33,, 351-364,[http:\/\/dx.doi.org\/10.1590\/S0101-28002011000300012]. [PMID: 22042353].","journal-title":"J Bras Nefrol"},{"key":"ref=52","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1161\/HYPERTENSIONAHA.110.164202","volume":"57","author":"Matavelli L.C.","year":"2011","unstructured":"Matavelli LC, Huang J, Siragy HM. 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Mol Vis, Topical administration of diminazene aceturate decreases inflammation in endotoxin-induced uveitis.,, 2015, 21,, 403-411,[PMID: 25883526].","journal-title":"Mol Vis"},{"key":"ref=55","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12974-016-0489-7","volume":"13","author":"Tao L.","year":"2016","unstructured":"Tao L, Qiu Y, Fu X, Lin R, Lei C, Wang J, Lei B. J Neuroinflammation, Angiotensin-converting enzyme 2 activator diminazene aceturate prevents lipopolysaccharide-induced inflammation by inhibiting MAPK and NF-\u03baB pathways in human retinal pigment epithelium.,, 2016, 13,, 35-,[http:\/\/dx.doi.org\/10.1186\/s12974-016-0489-7]. [PMID: 26862037].","journal-title":"J Neuroinflammation"},{"key":"ref=56","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.2174\/1389450117666160727142401","volume":"18","author":"Rodrigues Prestes T.R.","year":"2017","unstructured":"Rodrigues Prestes TR, Rocha NP, Miranda AS, Teixeira AL. Curr Drug Targets, Simoes-E-Silva, A.C. Simoes-E-Silva, A.C. The anti-inflammatory potential of ACE2\/Angiotensin-(1-7)\/Mas receptor axis: Evidence from basic and clinical research.,, 2017, 18,, 1301-1313,[http:\/\/dx.doi.org\/10.2174\/1389450117666160727142401]. 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