{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:44:13Z","timestamp":1787316253278,"version":"build-2736575974"},"reference-count":32,"publisher":"Bentham Science Publishers Ltd.","issue":"10","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["PPL"],"published-print":{"date-parts":[[2020,11,2]]},"abstract":"<jats:sec>\n                    <jats:title>Background:<\/jats:title>\n                    <jats:p>Combined maneb (MB) and paraquat (PQ), two widely used pesticides, increases\noxidative stress leading to Parkinsonism. Xenobiotic metabolizing enzymes, cytochrome\nP450 (CYP) 2D6 and its mouse ortholog Cyp2d22 protect against Parkinsonism. Resveratrol, an antioxidant,\nrestores antioxidant defense system through the activation of nuclear factor erythroid 2-\nrelated factor 2 (Nrf2). However, a crosstalk between Cyp2d22\/CYP2D6-mediated protection and\nresveratrol-induced Nrf2 activation leading to neuroprotection is not yet elucidated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>The study aimed to decipher the effect of resveratrol on Nrf2 activation and expression\nof its downstream mediators, nicotinamide adenine dinucleotide phosphate quinone oxidoreductase\n1 (NQO1) and thioredoxin 1 (Trx1) along with Cyp2d22\/CYP2D6 activity in combined MB and\nPQ mouse model of Parkinsonism and differentiated neuroblastoma cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>MB and PQ reduced the dopamine content (mouse) and Cyp2d22\/CYP2D6 activity\n(mouse\/neuroblastoma cells) and increased the nuclear translocation of Nrf2 and expression of\nNQO1 and Trx1 (both). Resveratrol ameliorated pesticides-induced changes in dopamine content\nand Cyp2d22\/CYP2D6 activity. It was found to promote nuclear translocation of Nrf2 and expression\nof NQO1 and Trx1 proteins. Since Cyp2d22\/CYP2D6 inhibitor (ketoconazole\/quinidine) per\nse reduced Cyp2d22\/CYP2D6 activity and dopamine content, it was found to substantially increase\nthe pesticides-induced reduction in Cyp2d22\/CYP2D6 activity and dopamine content. Inhibitors\nnormalized the pesticides induced changes in Nrf2 translocation and NQO1 and Trx1 levels in pesticides\ntreated groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion:<\/jats:title>\n                    <jats:p>The results suggest that resveratrol promotes the catalytic activity of xenobiotic metabolizing\nenzyme, Cyp2d22\/CYP2D6, which partially contributes to Nrf2 activation in pesticides-\ninduced Parkinsonism.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.2174\/0929866527666200403110036","type":"journal-article","created":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T12:08:39Z","timestamp":1585915719000},"page":"1038-1045","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Resveratrol Regulates Nrf2-Mediated Expression of Antioxidant and Xenobiotic Metabolizing Enzymes in Pesticides-Induced Parkinsonism"],"prefix":"10.2174","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7521-2919","authenticated-orcid":true,"given":"Mohd Sami Ur","family":"Rasheed","sequence":"first","affiliation":[{"name":"Toxicogenomics and Predictive Toxicology Laboratory, Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow 226 001, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3579-2197","authenticated-orcid":true,"given":"Manish Kumar","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Toxicogenomics and Predictive Toxicology Laboratory, Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow 226 001, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1187-6695","authenticated-orcid":true,"given":"Devendra Kumar","family":"Patel","sequence":"additional","affiliation":[{"name":"Analytical Chemistry Laboratory, Regulatory Toxicology Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow 226 001, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1198-6381","authenticated-orcid":true,"given":"Mahendra Pratap","family":"Singh","sequence":"additional","affiliation":[{"name":"Toxicogenomics and Predictive Toxicology Laboratory, Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology Research (CSIR-IITR), Lucknow 226 001, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"20313","DOI":"10.1074\/jbc.272.33.20313","volume":"272","author":"Berlett B.S.","year":"1997","unstructured":"Berlett B.S.; Stadtman E.R.; Protein oxidation in aging, disease, and oxidative stress. 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