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As mitochondria is losely related\nto energy metabolism, in this study, we investigated the changes in mitochondrial dynamics-related\nprotein (Drp1) expression under the action of NPY. miRNA-29a, a endogenous noncoding small\nmolecule RNA which is involved in many cardiac diseases, by using a bioinformatics tool, we found a\npotential binding site of miRNA-29a on the Drp1 mRNA, and suggesting that miRNA-29a might play\na regulatory role.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>Objective: To investigate the role of miR-29a-3p in the process of NPY-induced CH, and further\nexplore it\u2019s predicted relationship with Drp1.\nThe expression levels of miR-29a-3p and atrial natriuretic peptide (ANP) were performed by\nthe method of fluorescence quantitative PCR, in addition, expression of Drp1 in treated and control\ngroups were performed by western blot analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> We found NPY leads to the CH and up-regulation of ANP expression levels. We also found\nsignificant up-regulation of Drp1 expression and down-regulation of miR-29a-3p expression in NPYtreated cells. The decrease in miR-29a-3p expression may lead the increase expression level of Drp1.\nWe found that the expression of ANP increased after NPY treatment. When Drp1 protein was silenced,\nthe high expression of ANP was inhibited.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> In this study, we found up-regulation of Drp1 in cells treated with NPY. Drp1 mRNA is a\npredicted target for miR-29a-3p, and the expression of Drp1 was attenuated by miR-29a-3p. Therefore,\nNPY leads to down-regulation of miR-29a-3p expression, up-regulation of Drp1 expression, and NPY\nleads to CH. Correspondingly, miR-29a-3p can counteract the effects of NPY. This may be a new way,\nwhich could be used in diagnosis and treatment plan for CH.\n<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929866527666200416144459","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T11:31:01Z","timestamp":1587036661000},"page":"878-887","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Neuropeptide Y Induces Cardiomyocyte Hypertrophy via Attenuating miR-29a-3p in Neonatal Rat Cardiomyocytes"],"prefix":"10.2174","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7629-527X","authenticated-orcid":true,"given":"Yuxin","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Forensic Medicine, Medical College of Soochow University, Suzhou, Jiangsu 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8442-0341","authenticated-orcid":true,"given":"Jun","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Medical College of Soochow University, Suzhou, Jiangsu 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2170-9233","authenticated-orcid":true,"given":"Xincai","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Medical College of Soochow University, Suzhou, Jiangsu 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2331-6502","authenticated-orcid":true,"given":"Chunxiao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Forensic Expertise, De\u2019an Hospital, Changzhou, Jiangsu 213000, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0029-6775","authenticated-orcid":true,"given":"Yuanyi","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Medical College of Soochow University, Suzhou, Jiangsu 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9542-2406","authenticated-orcid":true,"given":"Shining","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Medical College of Soochow University, Suzhou, Jiangsu 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0367-5241","authenticated-orcid":true,"given":"Zhixiang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Medical College of Soochow University, Suzhou, Jiangsu 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0329-9231","authenticated-orcid":true,"given":"Shaohua","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, Medical College of Soochow University, Suzhou, Jiangsu 215123, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1423","DOI":"10.1093\/cvr\/cvx145","volume":"113","author":"van der Bruggen C.E.E.","year":"2017","unstructured":"van der Bruggen C.E.E.; Tedford R.J.; Handoko M.L.; van der Velden J.; de Man F.S.; RV pressure overload: From hypertrophy to failure. 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