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Since that time, the role\nof OCN as osteokine has been more and more widened appreciated and detailed by the major use\nof animal models, starting from the original function in the bone extracellular matrix as Gla-protein\nand spanning from the protective effects towards weight gain, insulin sensitivity and glucose homeostasis,\nto the anabolic and metabolic roles in skeletal muscle, to the stimulating effects on the\ntestis endocrine function and male fertility, to the most recent preservation from anxious and depressive\nstates through a direct activity on the central nervous system. In this review, experimental\ndata supporting the inter-organ communication roles of this protein are discussed, together with the\navailable data supporting the consistency between experimental data obtained in animals and those\nreported in humans. In addition, a specific session has been devoted to the possible significance the\nOCN as a template agonist on its receptor GPRC6A, for the development of novel therapeutic and\npharmacological approaches for the treatment of dismetabolic states and male infertility.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929866527666200505220459","type":"journal-article","created":{"date-parts":[[2020,5,6]],"date-time":"2020-05-06T08:50:27Z","timestamp":1588755027000},"page":"1268-1275","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Osteocalcin: A Protein Hormone Connecting Metabolism, Bone and Testis Function"],"prefix":"10.2174","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4958-5217","authenticated-orcid":true,"given":"Luca","family":"De Toni","sequence":"first","affiliation":[{"name":"Department of Medicine, Unit of Andrology and Reproductive Medicine, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6471-6644","authenticated-orcid":true,"given":"Kenda","family":"Jawich","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, Syrian Arab Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0821-3591","authenticated-orcid":true,"given":"Maurizio","family":"De Rocco Ponce","sequence":"additional","affiliation":[{"name":"Andrology Department, Fundacio Puigvert, Universitat Autonoma de Barcelona, Instituto de Investigaciones Biomedicas Sant Pau, Barcelona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7251-9210","authenticated-orcid":true,"given":"Andrea","family":"Di Nisio","sequence":"additional","affiliation":[{"name":"Department of Medicine, Unit of Andrology and Reproductive Medicine, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6576-2183","authenticated-orcid":true,"given":"Carlo","family":"Foresta","sequence":"additional","affiliation":[{"name":"Department of Medicine, Unit of Andrology and Reproductive Medicine, University of Padova, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"e47903","DOI":"10.15252\/embr.201947903","volume":"20","author":"Castillo-Armengol J.","year":"2019","unstructured":"Castillo-Armengol J.; Fajas L.; Lopez-Mejia I.C.; Inter-organ communication: A gatekeeper for metabolic health. 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