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Angiotensin (Ang)-(1-7) is an active peptide of the renin-angiotensin system\n(RAS) that stimulates ovarian follicular growth and testosterone release in vitro.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>To investigate whether Ang-(1-7), its receptor Mas and angiotensin-converting enzyme\n2 (ACE2), the enzyme that converts Ang II into Ang-(1-7), are expressed in rat polycystic ovaries\n(PCO) and thus if this peptide system might be associated with excess androgen production in\nPCO.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>A rat model that shares some features of PCOS such as disruption of folliculogenesis\nand multiple ovarian cyst formation was used in the study.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>We found reduced levels of Ang-(1-7) and Mas receptor in PCO compared to normal\novaries. Also, ACE2 mRNA expression was reduced in PCO compared to ovaries of control rats (p\n&lt; 0.05). PCO had high levels of estrogen and testosterone and increased mRNA for upstream enzymes\nof the steroidogenic cascade, but not of P450 aromatase.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>These findings suggest that the ovarian ACE2-Ang-(1-7)-Mas receptor axis is inhibited\nand therefore may not be a co-factor of excess testosterone production in rat PCO.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929866527666200826104410","type":"journal-article","created":{"date-parts":[[2020,8,27]],"date-time":"2020-08-27T11:13:23Z","timestamp":1598526803000},"page":"249-254","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Angiotensin-(1-7), Angiotensin-Converting Enzyme 2 and Mas Receptor in Rat Polycystic Ovaries"],"prefix":"10.2174","volume":"28","author":[{"given":"Virginia M.","family":"Pereira","sequence":"first","affiliation":[{"name":"Department of Physiology and Biophysics, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9258-7472","authenticated-orcid":true,"given":"Fernando M.","family":"Reis","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0015-3157","authenticated-orcid":true,"given":"Ma\u00edra","family":"Casalechi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0138-9612","authenticated-orcid":true,"given":"Adelina M.","family":"Reis","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1152\/physrev.00023.2016","volume":"98","author":"Santos R.A.S.","year":"2018","unstructured":"Santos R.A.S.; Sampaio W.O.; Alzamora A.C.; Motta-Santos D.; Alenina N.; Bader M.; Campagnole-Santos M.J.; The ACE2\/angiotensin-(1-7)\/MAS axis of the renin-angiotensin system: Focus on angiotensin-(1-7). 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