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CO-induced cardiotoxicity\nresulted in a wide range of disabilities including electrocardiogram (ECG) abnormalities,\nelevation in level of cardiac enzymes, arrhythmias, impairment of left ventricular and myocardial\ninfarction (MI). Cardio-protective effects of Granulocyte colony-stimulating factor (G-CSF) on infarcted\nheart was proved previously in various reports.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p> In this study, possible effect of G-CSF on cardiac function of patients with moderate to severe acute CO poisoning\nwas investigated.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p> Cardioprotective effects of G-CSF in CO-poisoned patients was evaluated through ECG, Holter monitoring,\nechocardiography, and biochemical studies. Continuous intravenous infusion of G-CSF (90 \u00b5g\/kg) and normal saline were\nadministered respectively to treatment and placebo groups.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>The results demonstrated that in moderate to severe CO poisoning, myocardial injury is\ncommon. ECG changes (e.g., ST-segment and T-wave changes, QTC), cardiac arrhythmias (e.g.,\nheart blocks and ventricular arrhythmias), serum level of Troponin I, left ventricular ejection fraction\nwere determined after G-CSF administration. Frequencies of ST depression, inversion or flatting\nof T wave and QTC in ECG were significantly reduced after G-CSF treatment. In addition, incidence\nof cardiac arrhythmias due to CO poisoning were reduced after G-CSF treatment. However,\nG-CSF did not exert protective effects on TPI level and function of left ventricular in CO-poisoned\npatients.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p> GCSF could probably reduce CO-induced cardiac ischemia in patients with acute CO poisoning.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929866527666201022112810","type":"journal-article","created":{"date-parts":[[2020,10,23]],"date-time":"2020-10-23T04:15:32Z","timestamp":1603426532000},"page":"589-601","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Evaluation of the Cardioprotective Effect of Granulocyte Colony Stimulating Factor in Patients with Carbon Monoxide Poisoning"],"prefix":"10.2174","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0380-0252","authenticated-orcid":true,"given":"Atena","family":"Pourtaji","sequence":"first","affiliation":[{"name":"Pharmaceutical Research Center, Department of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":true,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0764-6563","authenticated-orcid":true,"given":"Hoorak","family":"Poorzand","sequence":"additional","affiliation":[{"name":"Atherosclerosis Prevention Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0389-2270","authenticated-orcid":true,"given":"Mohammad","family":"Moshiri","sequence":"additional","affiliation":[{"name":"Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7517-8634","authenticated-orcid":true,"given":"Amir Hooshang","family":"Mohammadpour","sequence":"additional","affiliation":[{"name":"Pharmaceutical Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8082-8534","authenticated-orcid":true,"given":"Seyed Reza","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Medical Toxicology Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad,Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1016\/j.jacc.2005.01.044","volume":"45","author":"Satran D.","year":"2005","unstructured":"Satran D.; Henry C.R.; Adkinson C.; Nicholson C.I.; Bracha Y.; Henry T.D.; Cardiovascular manifestations of moderate to severe carbon monoxide poisoning. 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