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Generally, OSCC is often the end stage of several changes in the stratified squamous epithelium, which begin as epithelial dysplasia and progress by breaking the basement membrane and invading adjacent tissues. Several plant-based drugs with potent anti-cancer effects are considered inexpensive treatments with limited side effects for cancer and other diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective::<\/jats:title><jats:p>The aim of this review is to explore whether some Brazilian plant extracts or constituents exhibit anti-tumorigenic activity or have a cytotoxic effect on human oral carcinoma cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods::<\/jats:title><jats:p>Briefly, OSCC and several metabolites derived from Brazilian plants (i.e., flavonoids, vinblastine, irinotecan, etoposide and paclitaxel) were used as keywords to search the literature on PubMed, GenBank and GeneCards.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results::<\/jats:title><jats:p>The results showed that these five chemical compounds found in Cerrado Biome plants exhibit anti-neoplastic effects. Evaluating the compounds revealed that they play a main role in the regulation of cell proliferation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion::<\/jats:title><jats:p>Preserving and utilising the biodiversity of our planet, especially in unique ecosystems, such as the Cerrado Biome, may prove essential to preserving and promoting human health in modern contexts.<\/jats:p><\/jats:sec>","DOI":"10.2174\/0929866527999201209221012","type":"journal-article","created":{"date-parts":[[2020,12,11]],"date-time":"2020-12-11T04:05:44Z","timestamp":1607659544000},"page":"735-749","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Pathways Related to the Anti-Cancer Effects of Metabolites Derived from Cerrado Biome Native Plants: An Update and Bioinformatics Analysis on Oral Squamous Cell Carcinoma"],"prefix":"10.2174","volume":"28","author":[{"given":"Guilherme Machado","family":"Xavier","sequence":"first","affiliation":[{"name":"Department of Dentistry, King\u2019s College London, London, United Kingdom"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3162-3206","authenticated-orcid":true,"given":"Andr\u00e9 Luiz Sena","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Universidade Estadual de Montes Claros, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos Alberto","family":"de Carvalho Fraga","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Universidade Estadual de Montes Claros, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Talita Antunes","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Universidade Estadual de Montes Claros, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela Gon\u00e7alves","family":"de Souza","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Universidade Estadual de Montes Claros, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly Marie","family":"Jones","sequence":"additional","affiliation":[{"name":"Faculdades Integradas do Norte de Minas (FUNORTE), Montes Claros, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucyana Concei\u00e7\u00e3o","family":"Farias","sequence":"additional","affiliation":[{"name":"Department of Dentistry, Universidade Estadual de Montes Claros, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"609","volume":"19","author":"Lachenmeier D.W.","year":"2012","unstructured":"Lachenmeier D.W.; Alcohol-containing mouthwash and oral cancer-can epidemiology prove the absence of risk? 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