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Some specific fish peptides have anti-hypertensive effects.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p> In the present study, we hypothesized that the hexapeptide (MEVFVP) from flounder\nfish muscle can be a potent antihypertensive peptide, therefore, decided to perform this experiment.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>The peptide MEVFVP from flounder fish muscle (40 mg\/kg) and vehicle were administered\nper os to spontaneously hypertensive rats (SHRs) (SHR-M and SHR-C, respectively). Additionally,\nplasma MEVFVP was measured serially before and after its oral administration to\nSprague Dawley rats.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Blood pressures (BPs), especially systolic BP, in SHR rats were decreased around 3-6\nhours after MEVFVP administration. Compared with SHR-C rats, endothelin-1 (ET-1) mRNA expression\nin multiple tissues, and plasma levels of ET-1, angiotensin II, and aldosterone were lower\nin SHR-M rats, whereas the phosphorylation of AMP-activated protein kinase (AMPK) was increased\nin the kidney of SHR-M rats. The administered peptide was not detected in rat plasma,\nwhile ex vivo incubation of the peptide in rat plasma caused its rapid degradation within minutes.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Our results show that the MEVFVP has an antihypertensive effect by regulating renin-\nangiotensin-aldosterone system, ET-1 and AMPK despite its limited bioavailability.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929866528666210211142105","type":"journal-article","created":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T04:00:23Z","timestamp":1613102423000},"page":"831-840","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A Flounder Fish Peptide Shows Anti-Hypertensive Effects by Suppressing the Renin-Angiotensin-Aldosterone System and Endothelin-1"],"prefix":"10.2174","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4972-1277","authenticated-orcid":true,"given":"Mohamad","family":"Rahmdel","sequence":"first","affiliation":[{"name":"Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Min","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"You-Jin","family":"Jeon","sequence":"additional","affiliation":[{"name":"Department of Marine Life Science, Jeju National University, Jeju, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dae Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Health Sciences and Technology, GAIHST, Gachon University, Incheon, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"E1738","DOI":"10.3390\/nu10111738","volume":"10","author":"Chakrabarti S.","year":"2018","unstructured":"Chakrabarti S.; Guha S.; Majumder K.; Food-derived bioactive peptides in human health: challenges and opportunities. 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