{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T05:16:17Z","timestamp":1790140577914,"version":"4.0.1"},"reference-count":199,"publisher":"Bentham Science Publishers Ltd.","issue":"5","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["PPL"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:sec>\n<jats:title>Abstract:<\/jats:title>\n<jats:p>Food derived Antihypertensive peptides is considered as a natural supplement for controlling the hypertension. Food protein not only serve as a macronutrient but also act as raw material for biosynthesis of physiologically active peptides. Food sources like milk and milk products, animal protein such as meat, chicken, fish, eggs and plant derived proteins from soy, rice, wheat, mushroom, pumpkins contain high amount of antihypertensive peptides. The food derived antihypertensive peptides has ability to supress the action of rennin and Angiotesin converting enzyme (ACE) which is mainly involved in regulation of blood pressure by RAS. The biosynthesis of endothelial nitric oxide synthase is also improved by ACE inhibitory peptides which increase the production of nitric oxide in vascular walls and encourage vasodilation. Interaction between the angiotensin II and its receptor is also inhibited by the peptides which help to reduce hypertension. This review will explore the novel sources and applications of food derived peptides for the management of hypertension.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929866529666220106100225","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T11:54:26Z","timestamp":1641556466000},"page":"408-428","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Current Trends and Applications of Food-derived Antihypertensive\nPeptides for the Management of Cardiovascular Disease"],"prefix":"10.2174","volume":"29","author":[{"given":"Pratik","family":"Shukla","sequence":"first","affiliation":[{"name":"Department of Dairy Microbiology, SMC College of Dairy Science, Anand Agricultural University, Anand- 388110,\nGujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keval","family":"Chopada","sequence":"additional","affiliation":[{"name":"Department of Dairy Microbiology, SMC College of Dairy Science, Anand Agricultural University, Anand- 388110,\nGujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amar","family":"Sakure","sequence":"additional","affiliation":[{"name":"Department of Agricultural Biotechnology, Anand Agricultural University, Anand- 388110, Gujarat,\nIndia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subrota","family":"Hati","sequence":"additional","affiliation":[{"name":"Department of Dairy Microbiology, SMC College of Dairy Science, Anand Agricultural University, Anand- 388110,\nGujarat, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","first-page":"223","volume":"15","author":"Sharma S.","year":"2011","unstructured":"Sharma S.; Singh R.; Rana S.; Bioactive peptides: A review. Int J Bioautomation 2011,15,223-250","journal-title":"Int J Bioautomation"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1016\/j.peptides.2014.01.022","volume":"54","author":"Singh B.P.","year":"2014","unstructured":"Singh B.P.; Vij S.; Hati S.; Functional significance of bioactive peptides derived from soybean. Peptides 2014,54,171-179","journal-title":"Peptides"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/j.1473-2165.2009.00416.x","volume":"8","author":"Fields K.","year":"2009","unstructured":"Fields K.; Falla T.J.; Rodan K.; Bush L.; Bioactive peptides: Signaling the future. J Cosmet Dermatol 2009,8(1),8-13","journal-title":"J Cosmet Dermatol"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1007\/s12393-012-9058-8","volume":"4","author":"Carrasco-Castilla J.","year":"2012","unstructured":"Carrasco-Castilla J.; Hern\u00e1ndez-\u00c1lvarez A.J.; Jim\u00e9nez-Mart\u00ednez C.; Guti\u00e9rrez-L\u00f3pez G.F.; D\u00e1vila-Ortiz G.; Use of proteomics and peptidomics methods in food bioactive peptide science and engineering. Food Eng Rev 2012,4,224-243","journal-title":"Food Eng Rev"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1108\/NFS-10-2014-0088","volume":"45","author":"Bhat Z.F.","year":"2015","unstructured":"Bhat Z.F.; Kumar S.; Bhat H.F.; Bioactive peptides from egg: A review. Nutr Food Sci 2015,45,190-212","journal-title":"Nutr Food Sci"},{"key":"ref=6","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1007\/s00394-008-0710-2","volume":"47","author":"M\u00f6ller N.P.","year":"2008","unstructured":"M\u00f6ller N.P.; Scholz-Ahrens K.E.; Roos N.; Schrezenmeir J.; Bioactive peptides and proteins from foods: Indication for health effects. Eur J Nutr 2008,47(4),171-182","journal-title":"Eur J Nutr"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"430","DOI":"10.1080\/10408390701425615","volume":"48","author":"Elias R.J.","year":"2008","unstructured":"Elias R.J.; Kellerby S.S.; Decker E.A.; Antioxidant activity of proteins and peptides. Crit Rev Food Sci Nutr 2008,48(5),430-441","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"15","DOI":"10.2174\/138920106775789647","volume":"7","author":"Ramaa C.S.","year":"2006","unstructured":"Ramaa C.S.; Shirode A.R.; Mundada A.S.; Kadam V.J.; Nutraceuticals--an emerging era in the treatment and prevention of cardiovascular diseases. Curr Pharm Biotechnol 2006,7(1),15-23","journal-title":"Curr Pharm Biotechnol"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/j.jff.2009.01.007","volume":"1","author":"Korhonen H.","year":"2009","unstructured":"Korhonen H.; Milk-derived bioactive peptides: From science to applications. J Funct Foods 2009,1(2),177-187","journal-title":"J Funct Foods"},{"key":"ref=10","doi-asserted-by":"publisher","first-page":"4568","DOI":"10.1021\/jf060264q","volume":"54","author":"Mallikarjun Gouda K.G.","year":"2006","unstructured":"Mallikarjun Gouda K.G.; Gowda L.R.; Rao A.G.; Prakash V.; Angiotensin I-converting enzyme inhibitory peptide derived from glycinin, the 11S globulin of soybean (Glycine max). J Agric Food Chem 2006,54(13),4568-4573","journal-title":"J Agric Food Chem"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1124\/pr.112.006809","volume":"65","author":"Bernstein K.E.","year":"2012","unstructured":"Bernstein K.E.; Ong F.S.; Blackwell W.L.; Shah K.H.; Giani J.F.; Gonzalez-Villalobos R.A.; Shen X.Z.; Fuchs S.; Touyz R.M.; A modern understanding of the traditional and nontraditional biological functions of angiotensin-converting enzyme. Pharmacol Rev 2012,65(1),1-46","journal-title":"Pharmacol Rev"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1146\/annurev-food-022814-015520","volume":"6","author":"Aluko R.E.","year":"2015","unstructured":"Aluko R.E.; Antihypertensive peptides from food proteins. Annu Rev Food Sci Technol 2015,6,235-262","journal-title":"Annu Rev Food Sci Technol"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"256","DOI":"10.3390\/ijms16010256","volume":"16","author":"Majumder K.","year":"2014","unstructured":"Majumder K.; Wu J.; Molecular targets of antihypertensive peptides: understanding the mechanisms of action based on the pathophysiology of hypertension. Int J Mol Sci 2014,16(1),256-283","journal-title":"Int J Mol Sci"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"295","DOI":"10.1084\/jem.103.3.295","volume":"103","author":"Skeggs L.T.","year":"1956","unstructured":"Skeggs L.T.; Kahn J.R.; Shumway N.P.; The preparation and function of the hypertensin-converting enzyme. J Exp Med 1956,103(3),295-299","journal-title":"J Exp Med"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"9386","DOI":"10.1073\/pnas.85.24.9386","volume":"85","author":"Soubrier F.","year":"1988","unstructured":"Soubrier F.; Alhenc-Gelas F.; Hubert C.; Allegrini J.; John M.; Tregear G.; Corvol P.; Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning. Proc Natl Acad Sci USA 1988,85(24),9386-9390","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=16","first-page":"606","volume":"297","author":"Junot C.","year":"2001","unstructured":"Junot C.; Gonzales M.F.; Ezan E.; Cotton J.; Vazeux G.; Michaud A.; Azizi M.; Vassiliou S.; Yiotakis A.; Corvol P.; Dive V.; RXP 407, a selective inhibitor of the N-domain of angiotensin I-converting enzyme, blocks in vivo the degradation of hemoregulatory peptide acetyl-Ser-Asp-Lys-Pro with no effect on angiotensin I hydrolysis. J Pharmacol Exp Ther 2001,297(2),606-611","journal-title":"J Pharmacol Exp Ther"},{"key":"ref=17","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1016\/S0271-5317(04)00058-2","volume":"24","author":"Li G.","year":"2004","unstructured":"Li G.; Le G.; Shi Y.; Shrestha S.; Angiotensin I\u2013converting enzyme inhibitory peptides derived from food proteins and their physiological and pharmacological effects. Nutr Res Rev 2004,24(7),469-486","journal-title":"Nutr Res Rev"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"225","DOI":"10.1186\/gb-2003-4-8-225","volume":"4","author":"Riordan J.F.","year":"2003","unstructured":"Riordan J.F.; Angiotensin-I-converting enzyme and its relatives. Genome Biol 2003,4(8),225","journal-title":"Genome Biol"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"117","DOI":"10.2478\/v10042-009-0002-6","volume":"47","author":"Atanassova N.","year":"2009","unstructured":"Atanassova N.; Lakova E.; Bratchkova Y.; Krasteva G.; Donchev M.; Expression of testicular angiotensin-converting enzyme in adult spontaneously hypertensive rats. Folia Histochem Cytobiol 2009,47(1),117-122","journal-title":"Folia Histochem Cytobiol"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"15377","DOI":"10.1016\/S0021-9258(18)98626-6","volume":"266","author":"Hubert C.","year":"1991","unstructured":"Hubert C.; Houot A.M.; Corvol P.; Soubrier F.; Structure of the angiotensin I-converting enzyme gene. Two alternate promoters correspond to evolutionary steps of a duplicated gene. J Biol Chem 1991,266(23),15377-15383","journal-title":"J Biol Chem"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"2704","DOI":"10.1007\/s00018-004-4240-7","volume":"61","author":"Warner F.J.","year":"2004","unstructured":"Warner F.J.; Smith A.I.; Hooper N.M.; Turner A.J.; Angiotensin-converting enzyme-2: a molecular and cellular perspective. Cell Mol Life Sci 2004,61(21),2704-2713","journal-title":"Cell Mol Life Sci"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/S1357-2725(02)00309-6","volume":"35","author":"Coates D.","year":"2003","unstructured":"Coates D.; The angiotensin converting enzyme (ACE). Int J Biochem Cell Biol 2003,35(6),769-773","journal-title":"Int J Biochem Cell Biol"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"7807","DOI":"10.1073\/pnas.91.16.7807","volume":"91","author":"Deddish P.A.","year":"1994","unstructured":"Deddish P.A.; Wang J.; Michel B.; Morris P.W.; Davidson N.O.; Skidgel R.A.; Erd\u00f6s E.G.; Naturally occurring active N-domain of human angiotensin I-converting enzyme. Proc Natl Acad Sci USA 1994,91(16),7807-7811","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.bbrc.2016.10.155","volume":"481","author":"Conrad N.","year":"2016","unstructured":"Conrad N.; Schwager S.L.U.; Carmona A.K.; Sturrock E.D.; The effect of structural motifs on the ectodomain shedding of human angiotensin-converting enzyme. Biochem Biophys Res Commun 2016,481(1-2),111-116","journal-title":"Biochem Biophys Res Commun"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"739","DOI":"10.1042\/BJ20050187","volume":"389","author":"Woodman Z.L.","year":"2005","unstructured":"Woodman Z.L.; Schwager S.L.U.; Redelinghuys P.; Carmona A.K.; Ehlers M.R.W.; Sturrock E.D.; The N domain of somatic angiotensin-converting enzyme negatively regulates ectodomain shedding and catalytic activity. Biochem J 2005,389(Pt 3),739-744","journal-title":"Biochem J"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"964","DOI":"10.1016\/j.jmb.2006.01.048","volume":"357","author":"Corradi H.R.","year":"2006","unstructured":"Corradi H.R.; Schwager S.L.U.; Nchinda A.T.; Sturrock E.D.; Acharya K.R.; Crystal structure of the N domain of human somatic angiotensin I-converting enzyme provides a structural basis for domain-specific inhibitor design. J Mol Biol 2006,357(3),964-974","journal-title":"J Mol Biol"},{"key":"ref=27","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1016\/S0014-5793(03)00825-1","volume":"550","author":"Binevski P.V.","year":"2003","unstructured":"Binevski P.V.; Sizova E.A.; Pozdnev V.F.; Kost O.A.; Evidence for the negative cooperativity of the two active sites within bovine somatic angiotensin-converting enzyme. FEBS Lett 2003,550(1-3),84-88","journal-title":"FEBS Lett"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0165-6147(00)01994-5","volume":"23","author":"Turner A.J.","year":"2002","unstructured":"Turner A.J.; Hooper N.M.; The angiotensin-converting enzyme gene family: genomics and pharmacology. Trends Pharmacol Sci 2002,23(4),177-183","journal-title":"Trends Pharmacol Sci"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1079\/BJN20041189","volume":"92","author":"Vermeirssen V.","year":"2004","unstructured":"Vermeirssen V.; Van Camp J.; Verstraete W.; Bioavailability of angiotensin I converting enzyme inhibitory peptides. Br J Nutr 2004,92(3),357-366","journal-title":"Br J Nutr"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/B978-0-12-801028-0.00254-3","author":"Wong M.K.","year":"2016","unstructured":"Wong M.K.; Angiotensin converting enzymes. Handbook of Hormones 2016,263-e29D","journal-title":"Handbook of Hormones"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1097\/00004872-199306000-00003","volume":"11","author":"Soubrier F.","year":"1993","unstructured":"Soubrier F.; Wei L.; Hubert C.; Clauser E.; Alhenc-Gelas F.; Corvol P.; Molecular biology of the angiotensin I converting enzyme: II. Structure-function. Gene polymorphism and clinical implications. J Hypertens 1993,11(6),599-604","journal-title":"J Hypertens"},{"key":"ref=32","doi-asserted-by":"publisher","first-page":"L631","DOI":"10.1152\/ajplung.90415.2008","volume":"297","author":"Zhang R.","year":"2009","unstructured":"Zhang R.; Wu Y.; Zhao M.; Liu C.; Zhou L.; Shen S.; Liao S.; Yang K.; Li Q.; Wan H.; Role of HIF-1\u03b1 in the regulation ACE and ACE2 expression in hypoxic human pulmonary artery smooth muscle cells. Am J Physiol Lung Cell Mol Physiol 2009,297(4),L631-L640","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"ref=33","first-page":"1150","author":"McMurray J.","year":"2018","unstructured":"McMurray J.; Heart failure. The ESC textbook of cardiovascular medicine 2018,1150-1158","journal-title":"The ESC textbook of cardiovascular medicine"},{"key":"ref=34","first-page":"1795","volume":"68","author":"Scow D.T.","year":"2003","unstructured":"Scow D.T.; Smith E.G.; Shaughnessy A.F.; Combination therapy with ACE inhibitors and angiotensin-receptor blockers in heart failure. Am Fam Physician 2003,68(9),1795-1798","journal-title":"Am Fam Physician"},{"key":"ref=35","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/B978-1-4557-3322-4.00014-4","author":"Opie L.H.","year":"2013","unstructured":"Opie L.H.; Pfeffer M.A.; Inhibitors of the renin-angiotensin-aldosterone system. Drugs for the heart 2013,119-169","journal-title":"Drugs for the heart"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"3105","DOI":"10.1161\/01.CIR.92.10.3105","volume":"92","author":"Pieruzzi F.","year":"1995","unstructured":"Pieruzzi F.; Abassi Z.A.; Keiser H.R.; Expression of renin-angiotensin system components in the heart, kidneys, and lungs of rats with experimental heart failure. Circulation 1995,92(10),3105-3112","journal-title":"Circulation"},{"key":"ref=37","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1161\/01.CIR.90.4.1989","volume":"90","author":"Ruzicka M.","year":"1994","unstructured":"Ruzicka M.; Keeley F.W.; Leenen F.H.; The renin-angiotensin system and volume overload-induced changes in cardiac collagen and elastin. Circulation 1994,90(4),1989-1996","journal-title":"Circulation"},{"key":"ref=38","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1161\/01.RES.69.2.475","volume":"69","author":"Hirsch A.T.","year":"1991","unstructured":"Hirsch A.T.; Talsness C.E.; Schunkert H.; Paul M.; Dzau V.J.; Tissue-specific activation of cardiac angiotensin converting enzyme in experimental heart failure. Circ Res 1991,69(2),475-482","journal-title":"Circ Res"},{"key":"ref=39","doi-asserted-by":"publisher","first-page":"1513","DOI":"10.1161\/01.CIR.94.7.1513","volume":"94","author":"Hokimoto S.","year":"1996","unstructured":"Hokimoto S.; Yasue H.; Fujimoto K.; Yamamoto H.; Nakao K.; Kaikita K.; Sakata R.; Miyamoto E.; Expression of angiotensin-converting enzyme in remaining viable myocytes of human ventricles after myocardial infarction. Circulation 1996,94(7),1513-1518","journal-title":"Circulation"},{"key":"ref=40","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1016\/0092-8674(93)90541-W","volume":"75","author":"Sadoshima J.","year":"1993","unstructured":"Sadoshima J.; Xu Y.; Slayter H.S.; Izumo S.; Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell 1993,75(5),977-984","journal-title":"Cell"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"869","DOI":"10.1161\/01.HYP.23.6.869","volume":"23","author":"Weber K.T.","year":"1994","unstructured":"Weber K.T.; Sun Y.; Guarda E.; Structural remodeling in hypertensive heart disease and the role of hormones. Hypertension 1994,23(6 Pt 2),869-877","journal-title":"Hypertension"},{"key":"ref=42","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1056\/NEJM199209033271001","volume":"327","author":"Pfeffer M.A.","year":"1992","unstructured":"Pfeffer M.A.; Braunwald E.; Moy\u00e9 L.A.; Basta L.; Brown E.J.; Cuddy T.E.; Davis B.R.; Geltman E.M.; Goldman S.; Flaker G.C.; Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. N Engl J Med The SAVE Investigators1992,327(10),669-677","journal-title":"N Engl J Med"},{"key":"ref=43","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1113\/expphysiol.2007.040246","volume":"93","author":"Garabelli P.J.","year":"2008","unstructured":"Garabelli P.J.; Modrall J.G.; Penninger J.M.; Ferrario C.M.; Chappell M.C.; Distinct roles for angiotensin-converting enzyme 2 and carboxypeptidase A in the processing of angiotensins within the murine heart. Exp Physiol 2008,93(5),613-621","journal-title":"Exp Physiol"},{"key":"ref=44","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1161\/CIRCHEARTFAILURE.108.840124","volume":"2","author":"Kassiri Z.","year":"2009","unstructured":"Kassiri Z.; Zhong J.; Guo D.; Basu R.; Wang X.; Liu P.P.; Scholey J.W.; Penninger J.M.; Oudit G.Y.; Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. Circ Heart Fail 2009,2(5),446-455","journal-title":"Circ Heart Fail"},{"key":"ref=45","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1093\/cvr\/cvr036","volume":"91","author":"Bodiga S.","year":"2011","unstructured":"Bodiga S.; Zhong J.C.; Wang W.; Basu R.; Lo J.; Liu G.C.; Guo D.; Holland S.M.; Scholey J.W.; Penninger J.M.; Kassiri Z.; Oudit G.Y.; Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit. Cardiovasc Res 2011,91(1),151-161","journal-title":"Cardiovasc Res"},{"key":"ref=46","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1038\/nature00786","volume":"417","author":"Crackower M.A.","year":"2002","unstructured":"Crackower M.A.; Sarao R.; Oudit G.Y.; Yagil C.; Kozieradzki I.; Scanga S.E.; Oliveira-dos-Santos A.J.; da Costa J.; Zhang L.; Pei Y.; Scholey J.; Ferrario C.M.; Manoukian A.S.; Chappell M.C.; Backx P.H.; Yagil Y.; Penninger J.M.; Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature 2002,417(6891),822-828","journal-title":"Nature"},{"key":"ref=47","doi-asserted-by":"publisher","first-page":"718","DOI":"10.1161\/01.HYP.0000205833.89478.5b","volume":"47","author":"Yamamoto K.","year":"2006","unstructured":"Yamamoto K.; Ohishi M.; Katsuya T.; Ito N.; Ikushima M.; Kaibe M.; Tatara Y.; Shiota A.; Sugano S.; Takeda S.; Rakugi H.; Ogihara T.; Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II. Hypertension 2006,47(4),718-726","journal-title":"Hypertension"},{"key":"ref=48","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1291\/hypres.31.1953","volume":"31","author":"Nakamura K.","year":"2008","unstructured":"Nakamura K.; Koibuchi N.; Nishimatsu H.; Higashikuni Y.; Hirata Y.; Kugiyama K.; Nagai R.; Sata M.; Candesartan ameliorates cardiac dysfunction observed in angiotensin-converting enzyme 2-deficient mice. Hypertens Res 2008,31(10),1953-1961","journal-title":"Hypertens Res"},{"key":"ref=49","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/j.foodchem.2010.08.058","volume":"125","author":"Alem\u00e1n A.","year":"2011","unstructured":"Alem\u00e1n A.; Gim\u00e9nez B.; P\u00e9rez-Santin E.; G\u00f3mez-Guill\u00e9n M.C.; Montero P.; Contribution of Leu and Hyp residues to antioxidant and ACE-inhibitory activities of peptide sequences isolated from squid gelatin hydrolysate. Food Chem 2011,125(2),334-341","journal-title":"Food Chem"},{"key":"ref=50","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.foodchem.2011.07.011","volume":"130","author":"Pan D.","year":"2012","unstructured":"Pan D.; Cao J.; Guo H.; Zhao B.; Studies on purification and the molecular mechanism of a novel ACE inhibitory peptide from whey protein hydrolysate. Food Chem 2012,130(1),121-126","journal-title":"Food Chem"},{"key":"ref=51","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.idairyj.2006.05.011","volume":"17","author":"Otte J.","year":"2007","unstructured":"Otte J.; Shalaby S.M.; Zakora M.; Pripp A.H.; El-Shabrawy S.A.; Angiotensin-converting enzyme inhibitory activity of milk protein hydrolysates: Effect of substrate, enzyme and time of hydrolysis. Int Dairy J 2007,17(5),488-503","journal-title":"Int Dairy J"},{"key":"ref=52","doi-asserted-by":"publisher","first-page":"732","DOI":"10.1021\/jf051263l","volume":"54","author":"Wu J.","year":"2006","unstructured":"Wu J.; Aluko R.E.; Nakai S.; Structural requirements of Angiotensin I-converting enzyme inhibitory peptides: Quantitative structure-activity relationship study of di- and tripeptides. J Agric Food Chem 2006,54(3),732-738","journal-title":"J Agric Food Chem"},{"key":"ref=53","doi-asserted-by":"publisher","first-page":"450","DOI":"10.1016\/S0955-2863(00)00110-8","volume":"11","author":"Suetsuna K.","year":"2000","unstructured":"Suetsuna K.; Nakano T.; Identification of an antihypertensive peptide from peptic digest of wakame (Undaria pinnatifida). J Nutr Biochem 2000,11(9),450-454","journal-title":"J Nutr Biochem"},{"key":"ref=54","doi-asserted-by":"publisher","first-page":"6315","DOI":"10.1021\/jf049532f","volume":"52","author":"G\u00f3mez-Ruiz J.A.","year":"2004","unstructured":"G\u00f3mez-Ruiz J.A.; Recio I.; Belloque J.; ACE-inhibitory activity and structural properties of peptide Asp-Lys-Ile-His-Pro [\u03b2-CN f(47-51)]. Study of the peptide forms synthesized by different methods. J Agric Food Chem 2004,52(20),6315-6319","journal-title":"J Agric Food Chem"},{"key":"ref=55","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.jprot.2014.08.003","volume":"110","author":"Eckert E.","year":"2014","unstructured":"Eckert E.; Zambrowicz A.; Pokora M.; Setner B.; D\u0105browska A.; Szo\u0142tysik M.; Szewczuk Z.; Polanowski A.; Trziszka T.; Chrzanowska J.; Egg-yolk protein by-product as a source of ACE-inhibitory peptides obtained with using unconventional proteinase from Asian pumpkin (Cucurbita ficifolia). J Proteom 2014,110,107-116","journal-title":"J Proteom"},{"key":"ref=56","doi-asserted-by":"publisher","first-page":"C801","DOI":"10.1111\/j.1750-3841.2011.02228.x","volume":"76","author":"You S.J.","year":"2011","unstructured":"You S.J.; Wu J.; Angiotensin-I converting enzyme inhibitory and antioxidant activities of egg protein hydrolysates produced with gastrointestinal and nongastrointestinal enzymes. J Food Sci 2011,76(6),C801-C807","journal-title":"J Food Sci"},{"key":"ref=57","doi-asserted-by":"publisher","first-page":"875","DOI":"10.2174\/138161207780414278","volume":"13","author":"Mine Y.","year":"2007","unstructured":"Mine Y.; Egg proteins and peptides in human health--chemistry, bioactivity and production. Curr Pharm Des 2007,13(9),875-884","journal-title":"Curr Pharm Des"},{"key":"ref=58","author":"Hoppe A.","year":"2010","unstructured":"Hoppe A.;  Examination of egg white proteins and effects of high pressure on select physical and functional properties 2010","journal-title":"Examination of egg white proteins and effects of high pressure on select physical and functional properties"},{"key":"ref=59","doi-asserted-by":"publisher","first-page":"1159","DOI":"10.1016\/j.foodchem.2010.03.108","volume":"122","author":"Liu J.","year":"2010","unstructured":"Liu J.; Yu Z.; Zhao W.; Lin S.; Wang E.; Zhang Y.; Chen F.; Isolation and identification of angiotensin-converting enzyme inhibitory peptides from egg white protein hydrolysates. Food Chem 2010,122(4),1159-1163","journal-title":"Food Chem"},{"key":"ref=60","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/978-3-540-37885-3_24","author":"L\u00f3pez-Fandi\u00f1o R.","year":"2007","unstructured":"L\u00f3pez-Fandi\u00f1o R.; Recio I.; Ramos M.; Egg-protein derived peptides with antihypertensive activity. Physiological, chemical and technological aspects of milk-protein-derived peptides with antihypertensive and ACE-inhibitory activity. Bioactive Egg Compounds 2007,199-211","journal-title":"Bioactive Egg Compounds"},{"key":"ref=61","doi-asserted-by":"publisher","first-page":"1457","DOI":"10.1093\/jn\/136.6.1457","volume":"136","author":"Miguel M.","year":"2006","unstructured":"Miguel M.; Aleixandre A.; Antihypertensive peptides derived from egg proteins. J Nutr 2006,136(6),1457-1460","journal-title":"J Nutr"},{"key":"ref=62","doi-asserted-by":"publisher","first-page":"2344","DOI":"10.1271\/bbb.59.2344","volume":"59","author":"Fujita H.","year":"1995","unstructured":"Fujita H.; Sasaki R.; Yoshikawa M.; Potentiation of the antihypertensive activity of orally administered ovokinin, a vasorelaxing peptide derived from ovalbumin, by emulsification in egg phosphatidylcholine. Biosci Biotechnol Biochem 1995,59(12),2344-2345","journal-title":"Biosci Biotechnol Biochem"},{"key":"ref=63","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1007\/s10989-012-9311-2","volume":"18","author":"Memarpoor-Yazdi M.","year":"2012","unstructured":"Memarpoor-Yazdi M.; Asoodeh A.; Chamani J.; Structure and ACE-inhibitory activity of peptides derived from hen egg white lysozyme. Int J Pept Res Ther 2012,18(4),353-360","journal-title":"Int J Pept Res Ther"},{"key":"ref=64","doi-asserted-by":"publisher","first-page":"921","DOI":"10.1002\/jsfa.4266","volume":"91","author":"Yu Z.","year":"2011","unstructured":"Yu Z.; Zhao W.; Liu J.; Lu J.; Chen F.; QIGLF, a novel angiotensin I-converting enzyme-inhibitory peptide from egg white protein. J Sci Food Agric 2011,91(5),921-926","journal-title":"J Sci Food Agric"},{"key":"ref=65","doi-asserted-by":"publisher","first-page":"10615","DOI":"10.1021\/jf072307o","volume":"55","author":"Miguel M.","year":"2007","unstructured":"Miguel M.; Manso M.; Aleixandre A.; Alonso M.J.; Salaices M.; L\u00f3pez-Fandi\u00f1o R.; Vascular effects, angiotensin I-converting enzyme (ACE)-inhibitory activity, and antihypertensive properties of peptides derived from egg white. J Agric Food Chem 2007,55(26),10615-10621","journal-title":"J Agric Food Chem"},{"key":"ref=66","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1079\/BJN20051570","volume":"94","author":"Miguel M.","year":"2005","unstructured":"Miguel M.; L\u00f3pez-Fandi\u00f1o R.; Ramos M.; Aleixandre A.; Short-term effect of egg-white hydrolysate products on the arterial blood pressure of hypertensive rats. Br J Nutr 2005,94(5),731-737","journal-title":"Br J Nutr"},{"key":"ref=67","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1016\/S0014-5793(99)00587-6","volume":"452","author":"Matoba N.","year":"1999","unstructured":"Matoba N.; Usui H.; Fujita H.; Yoshikawa M.; A novel anti-hypertensive peptide derived from ovalbumin induces nitric oxide-mediated vasorelaxation in an isolated SHR mesenteric artery. FEBS Lett 1999,452(3),181-184","journal-title":"FEBS Lett"},{"key":"ref=68","doi-asserted-by":"publisher","first-page":"564","DOI":"10.1111\/j.1365-2621.2000.tb16049.x","volume":"65","author":"Iroyukifujita H.","year":"2000","unstructured":"Iroyukifujita H.; Eiichiyokoyama K.; Yoshikawa M.; Classification and antihypertensive activity of angiotensin I converting enzyme inhibitory peptides derived from food proteins. J Food Sci 2000,65(4),564-569","journal-title":"J Food Sci"},{"key":"ref=69","first-page":"27","volume":"128","author":"Yoshii H.","year":"2001","unstructured":"Yoshii H.; Tachi N.; Ohba R.; Sakamura O.; Takeyama H.; Itani T.; Antihypertensive effect of ACE inhibitory oligopeptides from chicken egg yolks. Comp. Biochem. Physiol. Part C Toxicol. Pharmacol 2001,128,27-33","journal-title":"Pharmacol"},{"key":"ref=70","doi-asserted-by":"publisher","first-page":"8106","DOI":"10.1021\/jf0508908","volume":"53","author":"Vercruysse L.","year":"2005","unstructured":"Vercruysse L.; Van Camp J.; Smagghe G.; ACE inhibitory peptides derived from enzymatic hydrolysates of animal muscle protein: A review. J Agric Food Chem 2005,53(21),8106-8115","journal-title":"J Agric Food Chem"},{"key":"ref=71","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1533\/9781845691615.41","author":"Lawrie R.A.","year":"2006","unstructured":"Lawrie R.A.; Ledward D.A.;  Meat Science 2006,41-73","journal-title":"Meat Science"},{"key":"ref=72","doi-asserted-by":"publisher","first-page":"4866","DOI":"10.1016\/S0021-9258(18)62016-2","volume":"246","author":"Spudich J.A.","year":"1971","unstructured":"Spudich J.A.; Watt S.; The regulation of rabbit skeletal muscle contraction. I. Biochemical studies of the interaction of the tropomyosin-troponin complex with actin and the proteolytic fragments of myosin. J Biol Chem 1971,246(15),4866-4871","journal-title":"J Biol Chem"},{"key":"ref=73","doi-asserted-by":"publisher","first-page":"516","DOI":"10.1016\/j.foodchem.2008.09.081","volume":"114","author":"Muguruma M.","year":"2009","unstructured":"Muguruma M.; Ahhmed A.M.; Katayama K.; Kawahara S.; Maruyama M.; Nakamura T.; Identification of pro-drug type ACE inhibitory peptide sourced from porcine myosin B: Evaluation of its antihypertensive effects in vivo. Food Chem 2009,114(2),516-522","journal-title":"Food Chem"},{"key":"ref=74","doi-asserted-by":"publisher","first-page":"S702","DOI":"10.1111\/j.1750-3841.2007.00571.x","volume":"72","author":"Katayama K.","year":"2007","unstructured":"Katayama K.; Mori T.; Kawahara S.; Miake K.; Kodama Y.; Sugiyama M.; Kawamura Y.; Nakayama T.; Maruyama M.; Muguruma M.; Angiotensin-I converting enzyme inhibitory peptide derived from porcine skeletal muscle myosin and its antihypertensive activity in spontaneously hypertensive rats. J Food Sci 2007,72(9),S702-S706","journal-title":"J Food Sci"},{"key":"ref=75","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1016\/j.jprot.2012.10.019","volume":"78","author":"Escudero E.","year":"2013","unstructured":"Escudero E.; Mora L.; Fraser P.D.; Aristoy M-C.; Arihara K.; Toldr\u00e1 F.; Purification and Identification of antihypertensive peptides in Spanish dry-cured ham. J Proteomics 2013,78,499-507","journal-title":"J Proteomics"},{"key":"ref=76","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/S0309-1740(00)00108-X","volume":"57","author":"Arihara K.","year":"2001","unstructured":"Arihara K.; Nakashima Y.; Mukai T.; Ishikawa S.; Itoh M.; Peptide inhibitors for angiotensin I-converting enzyme from enzymatic hydrolysates of porcine skeletal muscle proteins. Meat Sci 2001,57(3),319-324","journal-title":"Meat Sci"},{"key":"ref=77","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1111\/j.1365-2621.2002.tb11424.x","volume":"67","author":"Nakashima Y.","year":"2002","unstructured":"Nakashima Y.; Arihara K.; Sasaki A.; Mio H.; Ishikawa S.; Itoh M.; Antihypertensive activities of peptides derived from porcine skeletal muscle myosin in spontaneously hypertensive rats. J Food Sci 2002,67(1),434-437","journal-title":"J Food Sci"},{"key":"ref=78","first-page":"6262","volume":"6","author":"Ren Y.","year":"2011","unstructured":"Ren Y.; Wan D.G.; Lu X.M.; Chen L.; Zhang T.E.; Guo J.L.; Isolation and characterization of angiotensin I-converting enzyme inhibitor peptides derived from porcine hemoglobin. Sci Res Essays 2011,6(30),6262-6269","journal-title":"Sci Res Essays"},{"key":"ref=79","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1021\/jf0350865","volume":"52","author":"Katayama K.","year":"2004","unstructured":"Katayama K.; Tomatsu M.; Kawahara S.; Yamauchi K.; Fuchu H.; Kodama Y.; Kawamura Y.; Muguruma M.; Inhibitory profile of nonapeptide derived from porcine troponin C against angiotensin I-converting enzyme. J Agric Food Chem 2004,52(4),771-775","journal-title":"J Agric Food Chem"},{"key":"ref=80","doi-asserted-by":"publisher","first-page":"1531","DOI":"10.1016\/j.addr.2003.08.002","volume":"55","author":"Gelse K.","year":"2003","unstructured":"Gelse K.; P\u00f6schl E.; Aigner T.; Collagens--structure, function, and biosynthesis. Adv Drug Deliv Rev 2003,55(12),1531-1546","journal-title":"Adv Drug Deliv Rev"},{"key":"ref=81","doi-asserted-by":"publisher","first-page":"2992","DOI":"10.1021\/jf001119u","volume":"49","author":"Kim S-K.","year":"2001","unstructured":"Kim S-K.; Byun H.G.; Park P.J.; Shahidi F.; Angiotensin I converting enzyme inhibitory peptides purified from bovine skin gelatin hydrolysate. J Agric Food Chem 2001,49(6),2992-2997","journal-title":"J Agric Food Chem"},{"key":"ref=82","doi-asserted-by":"publisher","first-page":"653","DOI":"10.1016\/j.meatsci.2004.10.014","volume":"69","author":"Jang A.","year":"2005","unstructured":"Jang A.; Lee M.; Purification and identification of angiotensin converting enzyme inhibitory peptides from beef hydrolysates. Meat Sci 2005,69(4),653-661","journal-title":"Meat Sci"},{"key":"ref=83","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1021\/jf071408j","volume":"56","author":"Katayama K.","year":"2008","unstructured":"Katayama K.; Anggraeni H.E.; Mori T.; Ahhmed A.M.; Kawahara S.; Sugiyama M.; Nakayama T.; Maruyama M.; Muguruma M.; Porcine skeletal muscle troponin is a good source of peptides with Angiotensin-I converting enzyme inhibitory activity and antihypertensive effects in spontaneously hypertensive rats. J Agric Food Chem 2008,56(2),355-360","journal-title":"J Agric Food Chem"},{"key":"ref=84","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1021\/jf0508201","volume":"54","author":"Saiga A.","year":"2006","unstructured":"Saiga A.; Okumura T.; Makihara T.; Katsuda S.; Morimatsu F.; Nishimura T.; Action mechanism of an angiotensin I-converting enzyme inhibitory peptide derived from chicken breast muscle. J Agric Food Chem 2006,54(3),942-945","journal-title":"J Agric Food Chem"},{"key":"ref=85","doi-asserted-by":"publisher","first-page":"14077","DOI":"10.3390\/ijms150814077","volume":"15","author":"Darewicz M.","year":"2014","unstructured":"Darewicz M.; Borawska J.; Vegarud G.E.; Minkiewicz P.; Iwaniak A.; Angiotensin I-converting enzyme (ACE) inhibitory activity and ACE inhibitory peptides of salmon (Salmo salar) protein hydrolysates obtained by human and porcine gastrointestinal enzymes. Int J Mol Sci 2014,15(8),14077-14101","journal-title":"Int J Mol Sci"},{"key":"ref=86","first-page":"100","volume":"6","author":"Rasyad F.","year":"2016","unstructured":"Rasyad F.; Huang T.C.; Hsu J.L.; Fadjar M.; Screening of Novel angiotensin I converting enzyme inhibitory peptides derived from enzymatic hydrolysis of salmon protamine. J Life Sci Biomedicine 2016,6,100-105","journal-title":"J Life Sci Biomedicine"},{"key":"ref=87","doi-asserted-by":"publisher","first-page":"1536","DOI":"10.1016\/j.foodres.2011.04.006","volume":"44","author":"Gu R.Z.","year":"2011","unstructured":"Gu R.Z.; Li C.Y.; Liu W.Y.; Yi W.X.; Cai M.Y.; Angiotensin I-converting enzyme inhibitory activity of low-molecular-weight peptides from Atlantic salmon (Salmo salar) L. skin. Int Food Res J 2011,44(5),1536-1540","journal-title":"Int Food Res J"},{"key":"ref=88","doi-asserted-by":"publisher","first-page":"183","DOI":"10.5657\/FAS.2012.0183","volume":"15","author":"Kim S.R.","year":"2012","unstructured":"Kim S.R.; Byun H.G.; The novel angiotensin I converting enzyme inhibitory peptide from rainbow trout muscle hydrolysate. Fish Aquatic Sci 2012,15(3),183-190","journal-title":"Fish Aquatic Sci"},{"key":"ref=89","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1016\/j.foodchem.2009.04.086","volume":"118","author":"Lee S.H.","year":"2010","unstructured":"Lee S.H.; Qian Z.J.; Kim S.K.; A novel angiotensin I converting enzyme inhibitory peptide from tuna frame protein hydrolysate and its antihypertensive effect in spontaneously hypertensive rats. Food Chem 2010,118(1),96-102","journal-title":"Food Chem"},{"key":"ref=90","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1248\/bpb1978.12.566","volume":"12","author":"Kohama Y.","year":"1989","unstructured":"Kohama Y.; Oka H.; Matsumoto S.; Nakagawa T.; Miyamoto T.; Mimura T.; Nagase Y.; Satake M.; Takane T.; Fujita T.; Biological properties of angiotensin-converting enzyme inhibitor derived from tuna muscle. J Pharmacobiodyn 1989,12(9),566-571","journal-title":"J Pharmacobiodyn"},{"key":"ref=91","doi-asserted-by":"publisher","first-page":"8398","DOI":"10.1021\/jf0710635","volume":"55","author":"Qian Z.J.","year":"2007","unstructured":"Qian Z.J.; Je J.Y.; Kim S.K.; Antihypertensive effect of angiotensin i converting enzyme-inhibitory peptide from hydrolysates of Bigeye tuna dark muscle, Thunnus obesus. J Agric Food Chem 2007,55(21),8398-8403","journal-title":"J Agric Food Chem"},{"key":"ref=92","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1271\/bbb.57.695","volume":"57","author":"Matsumura N.","year":"1993","unstructured":"Matsumura N.; Fujii M.; Takeda Y.; Sugita K.; Shimizu T.; Angiotensin I-converting enzyme inhibitory peptides derived from bonito bowels autolysate. Biosci Biotechnol Biochem 1993,57(5),695-697","journal-title":"Biosci Biotechnol Biochem"},{"key":"ref=93","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1016\/S0162-3109(99)00118-6","volume":"44","author":"Fujita H.","year":"1999","unstructured":"Fujita H.; Yoshikawa M.; LKPNM: a prodrug-type ACE-inhibitory peptide derived from fish protein. Immunopharmacology 1999,44(1-2),123-127","journal-title":"Immunopharmacology"},{"key":"ref=94","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1016\/j.procbio.2005.06.032","volume":"41","author":"Hasan F.","year":"2006","unstructured":"Hasan F.; Kitagawa M.; Kumada Y.; Hashimoto N.; Shiiba M.; Katoh S.; Terashima M.; Production kinetics of angiotensin-I converting enzyme inhibitory peptides from bonito meat in artificial gastric juice. Process Biochem 2006,41,505-511","journal-title":"Process Biochem"},{"key":"ref=95","first-page":"239","volume":"35","author":"Byun H.G.","year":"2002","unstructured":"Byun H.G.; Kim S.K.; Structure and activity of angiotensin I converting enzyme inhibitory peptides derived from Alaskan pollack skin. J Biochem Mol Biol 2002,35(2),239-243","journal-title":"J Biochem Mol Biol"},{"key":"ref=96","doi-asserted-by":"publisher","first-page":"7842","DOI":"10.1021\/jf0494027","volume":"52","author":"Je J.Y.","year":"2004","unstructured":"Je J.Y.; Park P.J.; Kwon J.Y.; Kim S.K.; A novel angiotensin I converting enzyme inhibitory peptide from Alaska pollack (Theragra chalcogramma) frame protein hydrolysate. J Agric Food Chem 2004,52(26),7842-7845","journal-title":"J Agric Food Chem"},{"key":"ref=97","doi-asserted-by":"publisher","first-page":"1541","DOI":"10.1271\/bbb.56.1541","volume":"56","author":"Yokoyama K.","year":"1992","unstructured":"Yokoyama K.; Chiba H.; Yoshikawa M.; Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito. Biosci Biotechnol Biochem 1992,56(10),1541-1545","journal-title":"Biosci Biotechnol Biochem"},{"key":"ref=98","doi-asserted-by":"publisher","first-page":"519","DOI":"10.1038\/sj.jhh.1001065","volume":"14","author":"Kawasaki T.","year":"2000","unstructured":"Kawasaki T.; Seki E.; Osajima K.; Yoshida M.; Asada K.; Matsui T.; Osajima Y.; Antihypertensive effect of valyl-tyrosine, a short chain peptide derived from sardine muscle hydrolyzate, on mild hypertensive subjects. J Hum Hypertens 2000,14(8),519-523","journal-title":"J Hum Hypertens"},{"key":"ref=99","doi-asserted-by":"publisher","first-page":"2244","DOI":"10.1271\/bbb.58.2244","volume":"58","author":"Matsufuji H.","year":"1994","unstructured":"Matsufuji H.; Matsui T.; Seki E.; Osajima K.; Nakashima M.; Osajima Y.; Angiotensin I-converting enzyme inhibitory peptides in an alkaline protease hydrolyzate derived from sardine muscle. Biosci Biotechnol Biochem 1994,58(12),2244-2245","journal-title":"Biosci Biotechnol Biochem"},{"key":"ref=100","doi-asserted-by":"publisher","first-page":"5113","DOI":"10.1021\/jf900494d","volume":"57","author":"Guang C.","year":"2009","unstructured":"Guang C.; Phillips R.D.; Plant food-derived Angiotensin I converting enzyme inhibitory peptides. J Agric Food Chem 2009,57(12),5113-5120","journal-title":"J Agric Food Chem"},{"key":"ref=101","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1021\/jf903261h","volume":"58","author":"Nakahara T.","year":"2010","unstructured":"Nakahara T.; Sano A.; Yamaguchi H.; Sugimoto K.; Chikata H.; Kinoshita E.; Uchida R.; Antihypertensive effect of peptide-enriched soy sauce-like seasoning and identification of its angiotensin I-converting enzyme inhibitory substances. J Agric Food Chem 2010,58(2),821-827","journal-title":"J Agric Food Chem"},{"key":"ref=102","doi-asserted-by":"publisher","first-page":"67","DOI":"10.3136\/nskkk.58.67","volume":"58","author":"Nogata Y.","year":"2011","unstructured":"Nogata Y.; Nagamine T.; Sekiya K.; Antihypertensive effect of angiotensin I-converting enzyme inhibitory peptides derived from wheat bran in spontaneously hypertensive rats. Japanese Soc Food Sci Technol 2011,58,67-70","journal-title":"Japanese Soc Food Sci Technol"},{"key":"ref=103","first-page":"43","volume":"1","author":"Hashmi S.I.","year":"2016","unstructured":"Hashmi S.I.; Satwadhar P.N.; Khotpal R.R.; Deshpande H.W.; Syed K.A.; Vibhute B.P.; Rapeseed meal nutraceuticals. J Oilseeds Res 2016,1(2),43-54","journal-title":"J Oilseeds Res"},{"key":"ref=104","doi-asserted-by":"publisher","first-page":"791","DOI":"10.1016\/S0196-9781(03)00174-8","volume":"24","author":"Marczak E.D.","year":"2003","unstructured":"Marczak E.D.; Usui H.; Fujita H.; Yang Y.; Yokoo M.; Lipkowski A.W.; Yoshikawa M.; New antihypertensive peptides isolated from rapeseed. Peptides 2003,24(6),791-798","journal-title":"Peptides"},{"key":"ref=105","doi-asserted-by":"publisher","first-page":"942","DOI":"10.1016\/j.foodchem.2008.05.009","volume":"111","author":"Wu J.","year":"2008","unstructured":"Wu J.; Aluko R.E.; Muir A.D.; Purification of angiotensin I-converting enzyme-inhibitory peptides from the enzymatic hydrolysate of defatted canola meal. Food Chem 2008,111(4),942-950","journal-title":"Food Chem"},{"key":"ref=106","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1016\/j.foodchem.2011.11.024","volume":"132","author":"Udenigwe C.C.","year":"2012","unstructured":"Udenigwe C.C.; Adebiyi A.P.; Doyen A.; Li H.; Bazinet L.; Aluko R.E.; Low molecular weight flaxseed protein-derived arginine-containing peptides reduced blood pressure of spontaneously hypertensive rats faster than amino acid form of arginine and native flaxseed protein. Food Chem 2012,132(1),468-475","journal-title":"Food Chem"},{"key":"ref=107","doi-asserted-by":"publisher","first-page":"9596","DOI":"10.1021\/jf202000e","volume":"59","author":"Marambe H.K.","year":"2011","unstructured":"Marambe H.K.; Shand P.J.; Wanasundara J.P.; Release of angiotensin I-converting enzyme inhibitory peptides from flaxseed (Linum usitatissimum L.) protein under simulated gastrointestinal digestion. J Agric Food Chem 2011,59(17),9596-9604","journal-title":"J Agric Food Chem"},{"key":"ref=108","first-page":"59","volume":"8","author":"Iwaniak A.","year":"2009","unstructured":"Iwaniak A.; Dziuba B.; Motifs with potential physiological activity in food proteins\u2013BIOPEP database. Acta Sci Pol Technol Aliment 2009,8(3),59-85","journal-title":"Acta Sci Pol Technol Aliment"},{"key":"ref=109","doi-asserted-by":"publisher","first-page":"11983","DOI":"10.1021\/jf2033329","volume":"59","author":"Hu Y.","year":"2011","unstructured":"Hu Y.; Stromeck A.; Loponen J.; Lopes-Lutz D.; Schieber A.; G\u00e4nzle M.G.; LC-MS\/MS quantification of bioactive angiotensin I-converting enzyme inhibitory peptides in rye malt sourdoughs. J Agric Food Chem 2011,59(22),11983-11989","journal-title":"J Agric Food Chem"},{"key":"ref=110","doi-asserted-by":"publisher","first-page":"9234","DOI":"10.1021\/jf9018245","volume":"57","author":"Cheung I.W.","year":"2009","unstructured":"Cheung I.W.; Nakayama S.; Hsu M.N.; Samaranayaka A.G.; Li-Chan E.C.; Angiotensin-I converting enzyme inhibitory activity of hydrolysates from oat (Avena sativa) proteins by in silico and in vitro analyses. J Agric Food Chem 2009,57(19),9234-9242","journal-title":"J Agric Food Chem"},{"key":"ref=111","first-page":"275","volume":"16","author":"Li G.H.","year":"2007","unstructured":"Li G.H.; Qu M.R.; Wan J.Z.; You J.M.; Antihypertensive effect of rice protein hydrolysate with in vitro angiotensin I-converting enzyme inhibitory activity in spontaneously hypertensive rats. Asia Pac J Clin Nutr 2007,16(S1)(Suppl. 1),275-280","journal-title":"Asia Pac J Clin Nutr"},{"key":"ref=112","first-page":"1313","volume":"55","author":"Miyoshi S.","year":"1991","unstructured":"Miyoshi S.; Ishikawa H.; Kaneko T.; Fukui F.; Tanaka H.; Maruyama S.; Structures and activity of angiotensin-converting enzyme inhibitors in an \u03b1-zein hydrolysate. Agric Biol Chem 1991,55(5),1313-1318","journal-title":"Agric Biol Chem"},{"key":"ref=113","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1248\/bpb.23.427","volume":"23","author":"Matsui T.","year":"2000","unstructured":"Matsui T.; Li C.H.; Tanaka T.; Maki T.; Osajima Y.; Matsumoto K.; Depressor effect of wheat germ hydrolysate and its novel angiotensin I-converting enzyme inhibitory peptide, Ile-Val-Tyr, and the metabolism in rat and human plasma. Biol Pharm Bull 2000,23(4),427-431","journal-title":"Biol Pharm Bull"},{"key":"ref=114","first-page":"246","volume":"4","author":"Rai M.","year":"2005","unstructured":"Rai M.; Tidke G.; Wasser S.P.; Therapeutic potential of mushrooms. Indian J Nat Prod Resour 2005,4(4),246-257","journal-title":"Indian J Nat Prod Resour"},{"key":"ref=115","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/S0963-9969(00)00149-6","volume":"34","author":"Choi H.S.","year":"2001","unstructured":"Choi H.S.; Cho H.Y.; Yang H.C.; Ra K.S.; Suh H.J.; Angiotensin I-converting enzyme inhibitor from Grifola frondosa. Food Res Int 2001,34(2-3),177-182","journal-title":"Food Res Int"},{"key":"ref=116","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s00217-005-0147-2","volume":"222","author":"Li G.H.","year":"2006","unstructured":"Li G.H.; Shi Y.H.; Liu H.; Le G.W.; Antihypertensive effect of alcalase generated mung bean protein hydrolysates in spontaneously hypertensive rats. Eur Food Res Technol 2006,222(5),733-736","journal-title":"Eur Food Res Technol"},{"key":"ref=117","first-page":"745","volume":"52","author":"Sipola M.","year":"2001","unstructured":"Sipola M.; Finckenberg P.; Santisteban J.; Korpela R.; Vapaatalo H.; Nurminen M.L.; Long-term intake of milk peptides attenuates development of hypertension in spontaneously hypertensive rats. J Physiol Pharmacol 2001,52(4 Pt 2),745-754","journal-title":"J Physiol Pharmacol"},{"key":"ref=118","doi-asserted-by":"publisher","first-page":"5297","DOI":"10.1128\/AEM.69.9.5297-5305.2003","volume":"69","author":"Minervini F.","year":"2003","unstructured":"Minervini F.; Algaron F.; Rizzello C.G.; Fox P.F.; Monnet V.; Gobbetti M.; Angiotensin I-converting-enzyme-inhibitory and antibacterial peptides from Lactobacillus helveticus PR4 proteinase-hydrolyzed caseins of milk from six species. Appl Environ Microbiol 2003,69(9),5297-5305","journal-title":"Appl Environ Microbiol"},{"key":"ref=119","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1016\/S0958-6946(98)00060-0","volume":"8","author":"Takano T.","year":"1998","unstructured":"Takano T.; Milk derived peptides and hypertension reduction. Int Dairy J 1998,8(5-6),375-381","journal-title":"Int Dairy J"},{"key":"ref=120","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.idairyj.2005.12.011","volume":"17","author":"Quir\u00f3s A.","year":"2007","unstructured":"Quir\u00f3s A.; Ramos M.; Muguerza B.; Delgado M.A.; Miguel M.; Aleixandre A.; Recio I.; Identification of novel antihypertensive peptides in milk fermented with Enterococcus faecalis. Int Dairy J 2007,17(1),33-41","journal-title":"Int Dairy J"},{"key":"ref=121","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1079\/BJN20051450","volume":"94","author":"Miguel M.","year":"2005","unstructured":"Miguel M.; Muguerza B.; S\u00e1nchez E.; Delgado M.A.; Recio I.; Ramos M.; Aleixandre M.A.; Changes in arterial blood pressure in hypertensive rats caused by long-term intake of milk fermented by Enterococcus faecalis CECT 5728. Br J Nutr 2005,94(1),36-43","journal-title":"Br J Nutr"},{"key":"ref=122","first-page":"363","volume":"59","author":"Ashar M.N.","year":"2004","unstructured":"Ashar M.N.; Chand R.; Fermented milk containing ACE-inhibitory peptides reduces blood pressure in middle aged hypertensive subjects. Milchwissenschaft 2004,59(7-8),363-366","journal-title":"Milchwissenschaft"},{"key":"ref=123","doi-asserted-by":"publisher","first-page":"647","DOI":"10.1016\/j.foodchem.2007.04.028","volume":"105","author":"Papadimitriou C.G.","year":"2007","unstructured":"Papadimitriou C.G.; Vafopoulou-Mastrojiannaki A.; Silva S.V.; Gomes A.M.; Malcata F.X.; Alichanidis E.; Identification of peptides in traditional and probiotic sheep milk yoghurt with angiotensin I-converting enzyme (ACE)-inhibitory activity. Food Chem 2007,105(2),647-656","journal-title":"Food Chem"},{"key":"ref=124","doi-asserted-by":"publisher","first-page":"776","DOI":"10.1271\/bbb.58.776","volume":"58","author":"Yamamoto N.","year":"1994","unstructured":"Yamamoto N.; Akino A.; Takano T.; Antihypertensive effects of different kinds of fermented milk in spontaneously hypertensive rats. Biosci Biotechnol Biochem 1994,58(4),776-778","journal-title":"Biosci Biotechnol Biochem"},{"key":"ref=125","doi-asserted-by":"publisher","first-page":"980S","DOI":"10.1093\/jn\/134.4.980S","volume":"134","author":"FitzGerald R.J.","year":"2004","unstructured":"FitzGerald R.J.; Murray B.A.; Walsh D.J.; Hypotensive peptides from milk proteins. J Nutr 2004,134(4),980S-988S","journal-title":"J Nutr"},{"key":"ref=126","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.1016\/j.idairyj.2006.06.004","volume":"16","author":"L\u00f3pez-Fandi\u00f1o R.","year":"2006","unstructured":"L\u00f3pez-Fandi\u00f1o R.; Otte J.; Van Camp J.; Physiological, chemical and technological aspects of milk-protein-derived peptides with antihypertensive and ACE-inhibitory activity. Int Dairy J 2006,16(11),1277-1293","journal-title":"Int Dairy J"},{"key":"ref=127","doi-asserted-by":"publisher","first-page":"488","DOI":"10.1016\/j.idairyj.2006.05.011","volume":"17","author":"Maes W.","year":"2007","unstructured":"Maes W.; Van Camp J.; Vermeirssen V.; Hemeryck M.; Ketelslegers J.M.; Schrezenmeir J.; Otte J.; Shalaby S.M.; Kakora M.; Pripp A.H.; El-Shabrawy S.A.;  Int Dairy J 2007,17,488-203","journal-title":"Int Dairy J"},{"key":"ref=128","doi-asserted-by":"publisher","first-page":"1422","DOI":"10.1002\/mnfr.200900448","volume":"54","author":"Miguel M.","year":"2010","unstructured":"Miguel M.; G\u00f3mez-Ruiz J.\u00c1.; Recio I.; Aleixandre A.; Changes in arterial blood pressure after single oral administration of milk-casein-derived peptides in spontaneously hypertensive rats. Mol Nutr Food Res 2010,54(10),1422-1427","journal-title":"Mol Nutr Food Res"},{"key":"ref=129","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.3168\/jds.S0022-0302(96)76487-1","volume":"79","author":"Maeno M.","year":"1996","unstructured":"Maeno M.; Yamamoto N.; Takano T.; Identification of an antihypertensive peptide from casein hydrolysate produced by a proteinase from Lactobacillus helveticus CP790. J Dairy Sci 1996,79(8),1316-1321","journal-title":"J Dairy Sci"},{"key":"ref=130","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.idairyj.2009.05.004","volume":"19","author":"del Mar Contreras M.","year":"2009","unstructured":"del Mar Contreras M.; Carr\u00f3n R.; Montero M.J.; Ramos M.; Recio I.; Novel casein-derived peptides with antihypertensive activity. Int Dairy J 2009,19(10),566-573","journal-title":"Int Dairy J"},{"key":"ref=131","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.idairyj.2006.11.003","volume":"17","author":"B\u00fctikofer U.","year":"2007","unstructured":"B\u00fctikofer U.; Meyer J.; Sieber R.; Wechsler D.; Quantification of the angiotensin-converting enzyme-inhibiting tripeptides Val-Pro-Pro and Ile-Pro-Pro in hard, semi-hard and soft cheeses. Int Dairy J 2007,17(8),968-975","journal-title":"Int Dairy J"},{"key":"ref=132","first-page":"1405","volume":"49","author":"Maruyama S.","year":"1985","unstructured":"Maruyama S.; Nagakomi K.; Tomizuka N.; Suzuki H.;  Agric Biol Chem 1985,49,1405-1409","journal-title":"Agric Biol Chem"},{"key":"ref=133","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1006\/fmic.1999.0302","volume":"17","author":"Smacchi E.","year":"2000","unstructured":"Smacchi E.; Gobbetti M.; Bioactive peptides in dairy products: synthesis and interaction with proteolytic enzymes. Food Microbiol 2000,17(2),129-141","journal-title":"Food Microbiol"},{"key":"ref=134","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1016\/S0958-6946(02)00059-6","volume":"12","author":"G\u00f3mez-Ruiz J.\u00c1.","year":"2002","unstructured":"G\u00f3mez-Ruiz J.\u00c1.; Ramos M.; Recio I.; Angiotensin-converting enzyme-inhibitory peptides in Manchego cheeses manufactured with different starter cultures. Int Dairy J 2002,12(8),697-706","journal-title":"Int Dairy J"},{"key":"ref=135","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.3168\/jds.S0022-0302(99)75389-0","volume":"82","author":"Haileselassie S.S.","year":"1999","unstructured":"Haileselassie S.S.; Lee B.H.; Gibbs B.F.; Purification and identification of potentially bioactive peptides from enzyme-modified cheese. J Dairy Sci 1999,82(8),1612-1617","journal-title":"J Dairy Sci"},{"key":"ref=136","doi-asserted-by":"publisher","first-page":"1282","DOI":"10.1016\/j.foodchem.2006.10.041","volume":"103","author":"Mao X.Y.","year":"2007","unstructured":"Mao X.Y.; Ni J.R.; Sun W.L.; Hao P.P.; Fan L.; Value-added utilization of yak milk casein for the production of angiotensin-I-converting enzyme inhibitory peptides. Food Chem 2007,103(4),1282-1287","journal-title":"Food Chem"},{"key":"ref=137","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1016\/j.tifs.2014.06.007","volume":"39","author":"Fathi M.","year":"2014","unstructured":"Fathi M.; Martin A.; McClements D.J.; Nanoencapsulation of food ingredients using carbohydrate-based delivery systems. Trends Food Sci Technol 2014,39(1),18-39","journal-title":"Trends Food Sci Technol"},{"key":"ref=138","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1080\/87559129.2011.563395","volume":"27","author":"Segura-Campos M.","year":"2011","unstructured":"Segura-Campos M.; Chel-Guerrero L.D.A.; Betancur-Ancona.; Hernandez-Escalante, V, M. Food Res Int 2011,27,213-218","journal-title":"Food Res Int"},{"key":"ref=139","doi-asserted-by":"publisher","first-page":"296","DOI":"10.1016\/j.lwt.2013.12.019","volume":"56","author":"Ma J.J.","year":"2014","unstructured":"Ma J.J.; Mao X.Y.; Wang Q.; Yang S.; Zhang D.; Chen S.W.; Li Y.H.; Effect of spray drying and freeze drying on the immunomodulatory activity, bitter taste and hygroscopicity of hydrolysate derived from whey protein concentrate. Lebensm Wiss Technol 2014,56(2),296-302","journal-title":"Lebensm Wiss Technol"},{"key":"ref=140","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.lwt.2008.12.004","volume":"42","author":"Ortiz S.E.M.","year":"2009","unstructured":"Ortiz S.E.M.; Mauri A.; Monterrey-Quintero E.S.; Trindade M.A.; Santana A.S.; Favaro-Trindade C.S.; Production and properties of casein hydrolysate microencapsulated by spray drying with soybean protein isolate. Lebensm Wiss Technol 2009,42(5),919-923","journal-title":"Lebensm Wiss Technol"},{"key":"ref=141","doi-asserted-by":"publisher","first-page":"1305","DOI":"10.1007\/s11947-015-1472-5","volume":"8","author":"Wang Z.","year":"2015","unstructured":"Wang Z.; Ju X.; He R.; Yuan J.; Wang L.; The effect of rapeseed protein structural modification on microstructural properties of peptide microcapsules. Food Bioprocess Technol 2015,8(6),1305-1318","journal-title":"Food Bioprocess Technol"},{"key":"ref=142","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.tifs.2014.02.008","volume":"37","author":"Tavares G.M.","year":"2014","unstructured":"Tavares G.M.; Croguennec T.; Carvalho A.F.; Bouhallab S.; Milk proteins as encapsulation devices and delivery vehicles: Applications and trends. Trends Food Sci Technol 2014,37(1),5-20","journal-title":"Trends Food Sci Technol"},{"key":"ref=143","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.foodchem.2014.03.002","volume":"160","author":"O\u2019Neill G.J.","year":"2014","unstructured":"O\u2019Neill G.J.; Egan T.; Jacquier J.C.; O\u2019Sullivan M.; Dolores O\u2019Riordan E.; Whey microbeads as a matrix for the encapsulation and immobilisation of riboflavin and peptides. Food Chem 2014,160,46-52","journal-title":"Food Chem"},{"key":"ref=144","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1016\/j.foodhyd.2009.10.012","volume":"24","author":"Favaro-Trindade C.S.","year":"2010","unstructured":"Favaro-Trindade C.S.; Santana A.S.; Monterrey-Quintero E.S.; Trindade M.A.; Netto F.M.; The use of spray drying technology to reduce bitter taste of casein hydrolysate. Food Hydrocoll 2010,24(4),336-340","journal-title":"Food Hydrocoll"},{"key":"ref=145","doi-asserted-by":"publisher","first-page":"1313","DOI":"10.1039\/C6RA26536G","volume":"7","author":"Ren C.","year":"2017","unstructured":"Ren C.; Chu L.; Huang F.; Yang L.; Fan H.; Liu J.; A novel H2O2 responsive supramolecular hydrogel for controllable drug release. RSC Advances 2017,7(3),1313-1317","journal-title":"RSC Advances"},{"key":"ref=146","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1021\/bc300585h","volume":"24","author":"Zhang P.","year":"2013","unstructured":"Zhang P.; Cheetham A.G.; Lock L.L.; Cui H.; Cellular uptake and cytotoxicity of drug-peptide conjugates regulated by conjugation site. Bioconjug Chem 2013,24(4),604-613","journal-title":"Bioconjug Chem"},{"key":"ref=147","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1007\/978-3-319-39196-0_8","volume":"940","author":"Schloss A.C.","year":"2016","unstructured":"Schloss A.C.; Williams D.M.; Regan L.J.; Protein-based hydrogels for tissue engineering. Adv Exp Med Biol 2016,940,167-177","journal-title":"Adv Exp Med Biol"},{"key":"ref=148","doi-asserted-by":"publisher","first-page":"165","DOI":"10.2217\/nnm.09.103","volume":"5","author":"Vinogradov S.V.","year":"2010","unstructured":"Vinogradov S.V.; Nanogels in the race for drug delivery. Nanomedicine (Lond) 2010,5(2),165-168","journal-title":"Nanomedicine (Lond)"},{"key":"ref=149","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1021\/cm202640w","volume":"24","author":"Jonker A.M.","year":"2012","unstructured":"Jonker A.M.; L\u00f6wik D.W.P.M.; van Hest J.C.M.; Peptide and protein-based hydrogels. Chem Mater 2012,24(5),759-773","journal-title":"Chem Mater"},{"key":"ref=150","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1590\/S0104-66322012000200013","volume":"29","author":"Yokota D.","year":"2012","unstructured":"Yokota D.; Moraes M.; Pinho S.; Characterization of lyophilized liposomes produced with non-purified soy lecithin: A case study of casein hydrolysate microencapsulation. Braz J Chem Eng 2012,29(2),325-335","journal-title":"Braz J Chem Eng"},{"key":"ref=151","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1080\/10408398.2014.970267","volume":"56","author":"McClements J.","year":"2016","unstructured":"McClements J.; McClements D.J.; Standardization of nanoparticle characterization: methods for testing properties, stability, and functionality of edible nanoparticles. Crit Rev Food Sci Nutr 2016,56(8),1334-1362","journal-title":"Crit Rev Food Sci Nutr"},{"key":"ref=152","doi-asserted-by":"publisher","first-page":"1891","DOI":"10.1002\/jsfa.1855","volume":"84","author":"Barbosa C.M.","year":"2014","unstructured":"Barbosa C.M.; Morais H.A.; Delvivo F.M.; Mansur H.S.; De Oliveira M.C.; Silvestre M.P.; Papain hydrolysates of casein: molecular weight profile and encapsulation in lipospheres. J Sci Food Agric 2014,84(14),1891-1900","journal-title":"J Sci Food Agric"},{"key":"ref=153","first-page":"48","volume":"2","author":"Silva J.C.","year":"2013","unstructured":"Silva J.C.; Pinho S.C.;  Int J of Fin Stud 2013,2,48","journal-title":"Int J of Fin Stud"},{"key":"ref=154","doi-asserted-by":"publisher","first-page":"953","DOI":"10.1093\/jn\/137.4.953","volume":"137","author":"Foltz M.","year":"2007","unstructured":"Foltz M.; Meynen E.E.; Bianco V.; van Platerink C.; Koning T.M.; Kloek J.; Angiotensin converting enzyme inhibitory peptides from a lactotripeptide-enriched milk beverage are absorbed intact into the circulation. J Nutr 2007,137(4),953-958","journal-title":"J Nutr"},{"key":"ref=155","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1016\/j.peptides.2013.10.027","volume":"51","author":"Righard L.","year":"2014","unstructured":"Righard L.; Carlsson-Jonsson A.; Nyberg F.; Enhanced levels of immunoreactive \u03b2-casomorphin-8 in milk of breastfeeding women with mastitis. Peptides 2014,51,54-58","journal-title":"Peptides"},{"key":"ref=156","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.jff.2015.06.021","volume":"17","author":"Nongonierma A.B.","year":"2015","unstructured":"Nongonierma A.B.; FitzGerald R.J.; The scientific evidence for the role of milk protein-derived bioactive peptides in humans: A review. J Funct Foods 2015,17,640-656","journal-title":"J Funct Foods"},{"key":"ref=157","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1111\/1462-2920.13589","volume":"19","author":"Louis P.","year":"2017","unstructured":"Louis P.; Flint H.J.; Formation of propionate and butyrate by the human colonic microbiota. Environ Microbiol 2017,19(1),29-41","journal-title":"Environ Microbiol"},{"key":"ref=158","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1016\/j.lwt.2018.01.066","volume":"91","author":"Singh B.P.","year":"2018","unstructured":"Singh B.P.; Vij S.; In vitro stability of bioactive peptides derived from fermented soy milk against heat treatment, pH and gastrointestinal enzymes. Lebensm Wiss Technol 2018,91,303-307","journal-title":"Lebensm Wiss Technol"},{"key":"ref=159","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2020.111248","volume":"189","author":"Chakraborty A.","year":"2020","unstructured":"Chakraborty A.; Banerjee S.; Mukherjee B.; Poddar M.K.; Calorie restriction improves aging-induced impairment of cognitive function in relation to deregulation of corticosterone status and brain regional GABA system. Mech Ageing Dev 2020,189","journal-title":"Mech Ageing Dev"},{"key":"ref=160","doi-asserted-by":"publisher","first-page":"1005","DOI":"10.3945\/ajcn.117.158816","volume":"106","author":"Beaumont M.","year":"2017","unstructured":"Beaumont M.; Portune K.J.; Steuer N.; Lan A.; Cerrudo V.; Audebert M.; Dumont F.; Mancano G.; Khodorova N.; Andriamihaja M.; Airinei G.; Tom\u00e9 D.; Benamouzig R.; Davila A.M.; Claus S.P.; Sanz Y.; Blachier F.; Quantity and source of dietary protein influence metabolite production by gut microbiota and rectal mucosa gene expression: A randomized, parallel, double-blind trial in overweight humans. Am J Clin Nutr 2017,106(4),1005-1019","journal-title":"Am J Clin Nutr"},{"key":"ref=161","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.jff.2015.10.035","volume":"21","author":"Yu Y.J.","year":"2016","unstructured":"Yu Y.J.; Amorim M.; Marques C.; Calhau C.; Pintado M.; Effects of whey peptide extract on the growth of probiotics and gut microbiota. J Funct Foods 2016,21,507-516","journal-title":"J Funct Foods"},{"key":"ref=162","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1016\/j.ijpharm.2005.01.022","volume":"294","author":"Salamat-Miller N.","year":"2005","unstructured":"Salamat-Miller N.; Johnston T.P.; Current strategies used to enhance the paracellular transport of therapeutic polypeptides across the intestinal epithelium. Int J Pharm 2005,294(1-2),201-216","journal-title":"Int J Pharm"},{"key":"ref=163","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.foodchem.2016.08.106","volume":"218","author":"Wang B.","year":"2017","unstructured":"Wang B.; Li B.; Effect of molecular weight on the transepithelial transport and peptidase degradation of casein-derived peptides by using Caco-2 cell model. Food Chem 2017,218,1-8","journal-title":"Food Chem"},{"key":"ref=164","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/j.addr.2016.07.007","volume":"106","author":"Lundquist P.","year":"2016","unstructured":"Lundquist P.; Artursson P.; Oral absorption of peptides and nanoparticles across the human intestine: Opportunities, limitations and studies in human tissues. Adv Drug Deliv Rev 2016,106(Pt B),256-276","journal-title":"Adv Drug Deliv Rev"},{"key":"ref=165","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1021\/acs.jafc.7b05589","volume":"66","author":"Matsui T.","year":"2018","unstructured":"Matsui T.; Are peptides absorbable compounds? J Agric Food Chem 2018,66(2),393-394","journal-title":"J Agric Food Chem"},{"key":"ref=166","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/s40104-017-0219-8","volume":"9","author":"Xu Q.","year":"2018","unstructured":"Xu Q.; Liu Z.; Liu H.; Zhao F.; Huang X.; Wu Y.; Liu J.; Functional characterization of oliopeptide transporter 1 of dairy cows. J Anim Sci Biotechnol 2018,9(1),1-8","journal-title":"J Anim Sci Biotechnol"},{"key":"ref=167","doi-asserted-by":"publisher","first-page":"322","DOI":"10.3390\/nu10030322","volume":"10","author":"Jochems P.G.M.","year":"2018","unstructured":"Jochems P.G.M.; Garssen J.; van Keulen A.M.; Masereeuw R.; Jeurink P.V.; Evaluating human intestinal cell lines for studying dietary protein absorption. Nutrients 2018,10(3),322","journal-title":"Nutrients"},{"key":"ref=168","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.ijpharm.2013.02.030","volume":"447","author":"Renukuntla J.","year":"2013","unstructured":"Renukuntla J.; Vadlapudi A.D.; Patel A.; Boddu S.H.; Mitra A.K.; Approaches for enhancing oral bioavailability of peptides and proteins. Int J Pharm 2013,447(1-2),75-93","journal-title":"Int J Pharm"},{"key":"ref=169","doi-asserted-by":"publisher","first-page":"1428","DOI":"10.1002\/mnfr.200900443","volume":"54","author":"Regazzo D.","year":"2010","unstructured":"Regazzo D.; Moll\u00e9 D.; Gabai G.; Tom\u00e9 D.; Dupont D.; Leonil J.; Boutrou R.; The (193-209) 17-residues peptide of bovine \u03b2-casein is transported through Caco-2 monolayer. Mol Nutr Food Res 2010,54(10),1428-1435","journal-title":"Mol Nutr Food Res"},{"key":"ref=170","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1016\/j.addr.2016.06.002","volume":"110-111","author":"Komin A.","year":"2017","unstructured":"Komin A.; Russell L.M.; Hristova K.A.; Searson P.C.; Peptide-based strategies for enhanced cell uptake, transcellular transport, and circulation: Mechanisms and challenges. Adv Drug Deliv Rev 2017,110-111,52-64","journal-title":"Adv Drug Deliv Rev"},{"key":"ref=171","doi-asserted-by":"publisher","first-page":"681","DOI":"10.1016\/S0196-9781(97)00002-8","volume":"18","author":"Shimizu M.","year":"1997","unstructured":"Shimizu M.; Tsunogai M.; Arai S.; Transepithelial transport of oligopeptides in the human intestinal cell, Caco-2. Peptides 1997,18(5),681-687","journal-title":"Peptides"},{"key":"ref=172","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1021\/js960067d","volume":"85","author":"Burton P.S.","year":"1996","unstructured":"Burton P.S.; Conradi R.A.; Ho N.F.; Hilgers A.R.; Borchardt R.T.; How structural features influence the biomembrane permeability of peptides. J Pharm Sci 1996,85(12),1336-1340","journal-title":"J Pharm Sci"},{"key":"ref=173","doi-asserted-by":"publisher","first-page":"597","DOI":"10.1038\/nrd3187","volume":"9","author":"Sugano K.","year":"2010","unstructured":"Sugano K.; Kansy M.; Artursson P.; Avdeef A.; Bendels S.; Di L.; Ecker G.F.; Faller B.; Fischer H.; Gerebtzoff G.; Lennernaes H.; Senner F.; Coexistence of passive and carrier-mediated processes in drug transport. Nat Rev Drug Discov 2010,9(8),597-614","journal-title":"Nat Rev Drug Discov"},{"key":"ref=174","doi-asserted-by":"publisher","first-page":"2135","DOI":"10.2527\/jas.2007-0826","volume":"86","author":"Gilbert E.R.","year":"2008","unstructured":"Gilbert E.R.; Wong E.A.; Webb K.E.; Jr Board-invited review: Peptide absorption and utilization: Implications for animal nutrition and health. J Anim Sci 2008,86(9),2135-2155","journal-title":"J Anim Sci"},{"key":"ref=175","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088993","volume":"9","author":"Xu Q.","year":"2014","unstructured":"Xu Q.; Wu Y.; Liu H.; Xie Y.; Huang X.; Liu J.; Establishment and characterization of an omasal epithelial cell model derived from dairy calves for the study of small peptide absorption. PLoS One 2014,9(3)","journal-title":"PLoS One"},{"key":"ref=176","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1186\/s40104-017-0219-8","volume":"9","author":"Xu Q.","year":"2018","unstructured":"Xu Q.; Liu Z.; Liu H.; Zhao F.; Huang X.; Wu Y.; Liu J.; Functional characterization of oligopeptide transporter 1 of dairy cows. J Anim Sci Biotechnol 2018,9(1),7","journal-title":"J Anim Sci Biotechnol"},{"key":"ref=177","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1113\/EP085029","volume":"100","author":"Daniel H.","year":"2015","unstructured":"Daniel H.; Zietek T.; Taste and move: glucose and peptide transporters in the gastrointestinal tract. Exp Physiol 2015,100(12),1441-1450","journal-title":"Exp Physiol"},{"key":"ref=178","doi-asserted-by":"publisher","first-page":"3636","DOI":"10.1021\/jm0511029","volume":"49","author":"Vig B.S.","year":"2006","unstructured":"Vig B.S.; Stouch T.R.; Timoszyk J.K.; Quan Y.; Wall D.A.; Smith R.L.; Faria T.N.; Human PEPT1 pharmacophore distinguishes between dipeptide transport and binding. J Med Chem 2006,49(12),3636-3644","journal-title":"J Med Chem"},{"key":"ref=179","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1208\/s12248-010-9195-z","volume":"12","author":"Omkvist D.H.","year":"2010","unstructured":"Omkvist D.H.; Larsen S.B.; Nielsen C.U.; Steffansen B.; Olsen L.; J\u00f8rgensen F.S.; Brodin B.; A quantitative structure-activity relationship for translocation of tripeptides via the human proton-coupled peptide transporter, hPEPT1 (SLC15A1). AAPS J 2010,12(3),385-396","journal-title":"AAPS J"},{"key":"ref=180","doi-asserted-by":"publisher","first-page":"1753","DOI":"10.1016\/j.bbagen.2012.07.007","volume":"1820","author":"Kovacs-Nolan J.","year":"2012","unstructured":"Kovacs-Nolan J.; Zhang H.; Ibuki M.; Nakamori T.; Yoshiura K.; Turner P.V.; Matsui T.; Mine Y.; The PepT1-transportable soy tripeptide VPY reduces intestinal inflammation. Biochim Biophys Acta 2012,1820(11),1753-1763","journal-title":"Biochim Biophys Acta"},{"key":"ref=181","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062384","volume":"8","author":"Ding F.","year":"2013","unstructured":"Ding F.; Qian B.; Zhao X.; Shen S.; Deng Y.; Wang D.; Zhang F.; Sui Z.; Jing P.; VPPIPP and IPPVPP: Two hexapeptides innovated to exert antihypertensive activity. PLoS One 2013,8(4)","journal-title":"PLoS One"},{"key":"ref=182","doi-asserted-by":"publisher","first-page":"8143","DOI":"10.1021\/acs.jafc.5b01824","volume":"63","author":"Ding L.","year":"2015","unstructured":"Ding L.; Wang L.; Zhang Y.; Liu J.; Transport of antihypertensive peptide RVPSL, ovotransferrin 328\u2013332, in human intestinal Caco-2 cell monolayers. J Agric Food Chem 2015,63(37),8143-8150","journal-title":"J Agric Food Chem"},{"key":"ref=183","doi-asserted-by":"publisher","first-page":"7127","DOI":"10.1021\/acs.jafc.6b02955","volume":"64","year":"2016","unstructured":"Orally available collagen tripeptide: Enzymatic stability, intestinal permeability, and absorption of Gly-Pro-Hyp and ProHyp. J Agric Food Chem 2016,64,7127-7133","journal-title":"J Agric Food Chem"},{"key":"ref=184","doi-asserted-by":"publisher","first-page":"7406","DOI":"10.1021\/acs.jafc.7b02176","volume":"65","author":"Xu Q.","year":"2017","unstructured":"Xu Q.; Fan H.; Yu W.; Hong H.; Wu J.; Transport study of egg-derived antihypertensive peptides (LKP and IQW) using Caco-2 and HT29 coculture monolayers. J Agric Food Chem 2017,65(34),7406-7414","journal-title":"J Agric Food Chem"},{"key":"ref=185","doi-asserted-by":"publisher","first-page":"4306","DOI":"10.1039\/C7FO01185G","volume":"8","author":"Shen W.","year":"2017","unstructured":"Shen W.; Matsui T.; Current knowledge of intestinal absorption of bioactive peptides. Food Funct 2017,8(12),4306-4314","journal-title":"Food Funct"},{"key":"ref=186","doi-asserted-by":"publisher","first-page":"64","DOI":"10.1016\/j.ijpharm.2018.02.033","volume":"541","author":"Tao W.","year":"2018","unstructured":"Tao W.; Zhao D.; Sun M.; Wang Z.; Lin B.; Bao Y.; Li Y.; He Z.; Sun Y.; Sun J.; Intestinal absorption and activation of decitabine amino acid ester prodrugs mediated by peptide transporter PEPT1 and enterocyte enzymes. Int J Pharm 2018,541(1-2),64-71","journal-title":"Int J Pharm"},{"key":"ref=187","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.12489","volume":"43","author":"Kamdem J.P.","year":"2019","unstructured":"Kamdem J.P.; Tsopmo A.; Reactivity of peptides within the food matrix. J Food Biochem 2019,43(1)","journal-title":"J Food Biochem"},{"key":"ref=188","doi-asserted-by":"publisher","first-page":"3635","DOI":"10.1007\/s00018-011-0822-3","volume":"68","author":"Johansson M.E.","year":"2011","unstructured":"Johansson M.E.; Ambort D.; Pelaseyed T.; Sch\u00fctte A.; Gustafsson J.K.; Ermund A.; Subramani D.B.; Holm\u00e9n-Larsson J.M.; Thomsson K.A.; Bergstr\u00f6m J.H.; van der Post S.; Rodriguez-Pi\u00f1eiro A.M.; Sj\u00f6vall H.; B\u00e4ckstr\u00f6m M.; Hansson G.C.; Composition and functional role of the mucus layers in the intestine. Cell Mol Life Sci 2011,68(22),3635-3641","journal-title":"Cell Mol Life Sci"},{"key":"ref=189","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1111\/imr.12182","volume":"260","author":"Pelaseyed T.","year":"2014","unstructured":"Pelaseyed T.; Bergstr\u00f6m J.H.; Gustafsson J.K.; Ermund A.; Birchenough G.M.; Sch\u00fctte A.; van der Post S.; Svensson F.; Rodr\u00edguez-Pi\u00f1eiro A.M.; Nystr\u00f6m E.E.; Wising C.; Johansson M.E.; Hansson G.C.; The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system. Immunol Rev 2014,260(1),8-20","journal-title":"Immunol Rev"},{"key":"ref=190","doi-asserted-by":"publisher","first-page":"1817","DOI":"10.1007\/s11095-014-1578-x","volume":"32","author":"Lawless E.","year":"2015","unstructured":"Lawless E.; Griffin B.T.; O\u2019Mahony A.; O\u2019Driscoll C.M.; Exploring the impact of drug properties on the extent of intestinal lymphatic transport - in vitro and in vivo studies. Pharm Res 2015,32(5),1817-1829","journal-title":"Pharm Res"},{"key":"ref=191","doi-asserted-by":"publisher","first-page":"8166","DOI":"10.1021\/jf801140d","volume":"56","author":"Boutrou R.","year":"2008","unstructured":"Boutrou R.; Jardin J.; Blais A.; Tom\u00e9 D.; L\u00e9onil J.; Glycosylations of \u03ba-casein-derived caseinomacropeptide reduce its accessibility to endo- but not exointestinal brush border membrane peptidases. J Agric Food Chem 2008,56(17),8166-8173","journal-title":"J Agric Food Chem"},{"key":"ref=192","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1023\/A:1012040425146","volume":"14","author":"Pauletti G.M.","year":"1997","unstructured":"Pauletti G.M.; Okumu F.W.; Borchardt R.T.; Effect of size and charge on the passive diffusion of peptides across Caco-2 cell monolayers via the paracellular pathway. Pharm Res 1997,14(2),164-168","journal-title":"Pharm Res"},{"key":"ref=193","doi-asserted-by":"publisher","first-page":"S33","DOI":"10.1017\/S0007114500002221","volume":"84","author":"FitzGerald R.J.","year":"2000","unstructured":"FitzGerald R.J.; Meisel H.; Milk protein-derived peptide inhibitors of angiotensin-I-converting enzyme. Br J Nutr 2000,84(Suppl. 1),S33-S37","journal-title":"Br J Nutr"},{"key":"ref=194","doi-asserted-by":"publisher","first-page":"781","DOI":"10.1590\/S0100-40422004000500018","volume":"27","author":"Machado A.","year":"2004","unstructured":"Machado A.; Liria C.W.; Proti P.B.; Remuzgo C.; Miranda M.T.M.; S\u00ednteses qu\u00edmica e enzim\u00e1tica de pept\u00eddeos: Princ\u00edpios b\u00e1sicos e aplica\u00e7\u00f5es. Quim Nova 2004,27(1),781-789","journal-title":"Quim Nova"},{"key":"ref=195","first-page":"11","author":"Yakimova B.K.","year":"2017","unstructured":"Yakimova B.K.; Petkova D.; Stoineva I.B.; Molecular design and chemical synthesis of peptide inhibitors of Angiotensin I converting enzyme (ACE) for prevention and therapy of hypertension. Bulgarian Chem Commun 2017,11-15","journal-title":"Bulgarian Chem Commun"},{"key":"ref=196","doi-asserted-by":"publisher","first-page":"5109","DOI":"10.1093\/bioinformatics\/btaa645","volume":"36","author":"Kong R.","year":"2020","unstructured":"Kong R.; Yang G.; Xue R.; Liu M.; Wang F.; Hu J.; Guo X.; Chang S.; COVID-19 Docking Server: A meta server for docking small molecules, peptides and antibodies against potential targets of COVID-19. Bioinformatics 2020,36(20),5109-5111","journal-title":"Bioinformatics"},{"key":"ref=197","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2020.104742","volume":"176","author":"Coutard B.","year":"2020","unstructured":"Coutard B.; Valle C.; de Lamballerie X.; Canard B.; Seidah N.G.; Decroly E.; The spike glycoprotein of the new coronavirus 2019-nCoV contains a furin-like cleavage site absent in CoV of the same clade. Antiviral Res 2020,176","journal-title":"Antiviral Res"},{"key":"ref=198","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2020.173781","volume":"891","author":"\u00c7ak\u0131r B.","year":"2021","unstructured":"\u00c7ak\u0131r B.; Okuyan B.; \u015eener G.; Tunali-Akbay T.; Investigation of beta-lactoglobulin derived bioactive peptides against SARS-CoV-2 (COVID-19): In silico analysis. Eur J Pharmacol 2021,891","journal-title":"Eur J Pharmacol"},{"key":"ref=199","doi-asserted-by":"publisher","first-page":"11727","DOI":"10.1073\/pnas.2003138117","volume":"117","author":"Shang J.","year":"2020","unstructured":"Shang J.; Wan Y.; Luo C.; Ye G.; Geng Q.; Auerbach A.; Li F.; Cell entry mechanisms of SARS-CoV-2. Proc Natl Acad Sci USA 2020,117(21),11727-11734","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Protein &amp; Peptide Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0929866529666220106100225","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/200039\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0929866529666220106100225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T16:57:47Z","timestamp":1692896267000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/200039\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":199,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929866529666220106100225","relation":{},"ISSN":["0929-8665"],"issn-type":[{"value":"0929-8665","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2021-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-26","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-27","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}