{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T21:23:38Z","timestamp":1788384218799,"version":"build-2803163510"},"reference-count":42,"publisher":"Bentham Science Publishers Ltd.","issue":"7","funder":[{"name":"Science and Technology Foundation of Jiangxi Province","award":["20212BAB206039"],"award-info":[{"award-number":["20212BAB206039"]}]},{"DOI":"10.13039\/501100004637","name":"Youth Research and Innovation Fund of the First Affiliated Hospital of Nanchang University","doi-asserted-by":"publisher","award":["YFYPY202110"],"award-info":[{"award-number":["YFYPY202110"]}],"id":[{"id":"10.13039\/501100004637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["PPL"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n<jats:title>Abstract:<\/jats:title>\n<jats:p>Protein tyrosine phosphatase receptor-type Q (PTPRQ), a member of the type III tyrosine\nphosphatase receptor (R3 PTPR) family, is composed of three domains, including 18 extracellular\nfibronectin type III (FN3) repeats, a transmembrane helix, and a cytoplasmic phosphotyrosine\nphosphatase (PTP) domain. PTPRQ was initially identified as a transcript upregulated in glomerular\nmesangial cells in a rat model of glomerulonephritis. Subsequently, studies found that PTPRQ has\nphosphotyrosine phosphatase and phosphatidylinositol phosphatase activities and can regulate cell\nproliferation, apoptosis, differentiation, and survival. Further in vivo studies showed that PTPRQ is\nnecessary for the maturation of cochlear hair bundles and is considered a potential gene for\ndeafness. In the recent two decades, 21 mutations in PTPRQ have been linked to autosomal\nrecessive hearing loss (DFNB84) and autosomal dominant hearing loss (DFNA73). Recent\nmutations, deletions, and amplifications of PTPRQ have been observed in many types of cancers,\nwhich indicate that PTPRQ might play an essential role in the development of many cancers. In this\nreview, we briefly describe PTPRQ structure and enzyme activity and focus on the correlation\nbetween PTPRQ and human disease. A profound understanding of PTPRQ could be helpful in the\nidentification of new therapeutic targets to treat associated diseases.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929866529666220511141826","type":"journal-article","created":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T05:14:28Z","timestamp":1652332468000},"page":"567-573","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Protein Tyrosine Phosphatase Receptor-type Q: Structure, Activity, and\nImplications in Human Disease"],"prefix":"10.2174","volume":"29","author":[{"given":"Wansi","family":"Zhang","sequence":"first","affiliation":[{"name":"Jiangxi Medical Center for Major Public Health Events, The First Affiliated Hospital of Nanchang University,\nNanchang, Jiangxi, 330013, China"},{"name":"Jiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology\nand Department of Pathophysiology, Schools of Basic Medical Sciences, Nanchang University Medical College,\nNanchang, Jiangxi, 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Tang","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology\nand Department of Pathophysiology, Schools of Basic Medical Sciences, Nanchang University Medical College,\n, Jiangxi, 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shipan","family":"Fan","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology\nand Department of Pathophysiology, Schools of Basic Medical Sciences, Nanchang University Medical College,\nNanchang, Jiangxi, 330006, China"},{"name":"Guangzhou Regenerative Medicine and Health Guangdong Laboratory (GRMHGDL),\nGuangzhou 510005, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dingjin","family":"Yao","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology\nand Department of Pathophysiology, Schools of Basic Medical Sciences, Nanchang University Medical College,\nNanchang, Jiangxi, 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Queen Mary School, Nanchang University, Nanchang, 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxi","family":"Guan","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology\nand Department of Pathophysiology, Schools of Basic Medical Sciences, Nanchang University Medical College,\nNanchang, Jiangxi, 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxin","family":"Deng","sequence":"additional","affiliation":[{"name":"Jiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology\nand Department of Pathophysiology, Schools of Basic Medical Sciences, Nanchang University Medical College,\nNanchang, Jiangxi, 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Ying","sequence":"additional","affiliation":[{"name":"Jiangxi Medical Center for Major Public Health Events, The First Affiliated Hospital of Nanchang University,\nNanchang, Jiangxi, 330013, China"},{"name":"Jiangxi Province Key Laboratory of Tumor Pathogens and Molecular Pathology\nand Department of Pathophysiology, Schools of Basic Medical Sciences, Nanchang University Medical College,\nNanchang, Jiangxi, 330006, China"},{"name":"The Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Nanchang University,\nNanchang,  Jiangxi, 330006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188442","volume":"1874","author":"Taddei M.L.","year":"2020","unstructured":"Taddei M.L.; Pardella E.; Pranzini E.; Raugei G.; Paoli P.; Role of tyrosine phosphorylation in modulating cancer cell metabolism. Biochim Biophys Acta Rev Cancer 2020,1874(2)","journal-title":"Biochim Biophys Acta Rev Cancer"},{"key":"ref=2","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1016\/bs.acr.2021.06.001","volume":"152","author":"Welsh C.L.","year":"2021","unstructured":"Welsh C.L.; Pandey P.; Ahuja L.G.; Protein tyrosine phosphatases: A new paradigm in an old signaling system? Adv Cancer Res 2021,152,263-303","journal-title":"Adv Cancer Res"},{"key":"ref=3","doi-asserted-by":"publisher","first-page":"23929","DOI":"10.1074\/jbc.273.37.23929","volume":"273","author":"Wright M.B.","year":"1998","unstructured":"Wright M.B.; Hugo C.; Seifert R.; Disteche C.M.; Bowen-Pope D.F.; Proliferating and migrating mesangial cells responding to injury express a novel receptor protein-tyrosine phosphatase in experimental mesangial proliferative glomerulonephritis. J Biol Chem 1998,273(37),23929-23937","journal-title":"J Biol Chem"},{"key":"ref=4","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1016\/j.heares.2019.01.003","volume":"376","author":"Kremer H.","year":"2019","unstructured":"Kremer H.; Hereditary hearing loss; about the known and the unknown. Hear Res 2019,376,58-68","journal-title":"Hear Res"},{"key":"ref=5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1111\/ahg.12442","volume":"86","author":"Vanniya S.P.","year":"2021","unstructured":"Vanniya S.P.; Chandru J.; Jeffrey J.M.; Rabinowitz T.; Brownstein Z.; Krishnamoorthy M.; Avraham K.B.; PNPT1, MYO15A, PTPRQ, and SLC12A2-associated genetic and phenotypic heterogeneity among hearing impaired assortative mating families in Southern India. Ann Hum Genet 2021,86(1),1-13","journal-title":"Ann Hum Genet"},{"key":"ref=6","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5584788","volume":"2021","author":"Mahmood U.","year":"2021","unstructured":"Mahmood U.; Bukhari S.A.; Ali M.; Ahmed Z.M.; Riazuddin S.; Identification of hearing loss-associated variants of PTPRQ, MYO15A, and SERPINB6 in Pakistani families. BioMed Res Int 2021,2021","journal-title":"BioMed Res Int"},{"key":"ref=7","doi-asserted-by":"publisher","first-page":"744","DOI":"10.1111\/ejn.12484","volume":"39","author":"Chen J.","year":"2014","unstructured":"Chen J.; Johnson S.L.; Lewis M.A.; Hilton J.M.; Huma A.; Marcotti W.; Steel K.P.; A reduction in Ptprq associated with specific features of the deafness phenotype of the miR-96 mutant mouse diminuendo. Eur J Neurosci 2014,39(5),744-756","journal-title":"Eur J Neurosci"},{"key":"ref=8","doi-asserted-by":"publisher","first-page":"61","DOI":"10.5732\/cjc.014.10146","volume":"34","author":"Du Y.","year":"2015","unstructured":"Du Y.; Grandis J.R.; Receptor-type protein tyrosine phosphatases in cancer. Chin J Cancer 2015,34(2),61-69","journal-title":"Chin J Cancer"},{"key":"ref=9","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1016\/j.prp.2014.07.010","volume":"210","author":"Laczmanska I.","year":"2014","unstructured":"Laczmanska I.; Karpinski P.; Kozlowska J.; Bebenek M.; Ramsey D.; Sedziak T.; Ziolkowski P.; Sasiadek M.M.; Copy number alterations of chromosomal regions enclosing protein tyrosine phosphatase receptor-like genes in colorectal cancer. Pathol Res Pract 2014,210(12),893-896","journal-title":"Pathol Res Pract"},{"key":"ref=10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0087113","volume":"9","author":"Egan J.B.","year":"2014","unstructured":"Egan J.B.; Barrett M.T.; Champion M.D.; Middha S.; Lenkiewicz E.; Evers L.; Francis P.; Schmidt J.; Shi C.X.; Van Wier S.; Badar S.; Ahmann G.; Kortuem K.M.; Boczek N.J.; Fonseca R.; Craig D.W.; Carpten J.D.; Borad M.J.; Stewart A.K.; Whole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 rearrangements. PLoS One 2014,9(2)","journal-title":"PLoS One"},{"key":"ref=11","doi-asserted-by":"publisher","first-page":"374","DOI":"10.1016\/S0014-4827(03)00121-6","volume":"287","author":"Seifert R.A.","year":"2003","unstructured":"Seifert R.A.; Coats S.A.; Oganesian A.; Wright M.B.; Dishmon M.; Booth C.J.; Johnson R.J.; Alpers C.E.; Bowen-Pope D.F.; PTPRQ is a novel phosphatidylinositol phosphatase that can be expressed as a cytoplasmic protein or as a subcellularly localized receptor-like protein. Exp Cell Res 2003,287(2),374-386","journal-title":"Exp Cell Res"},{"key":"ref=12","doi-asserted-by":"publisher","first-page":"9208","DOI":"10.1523\/JNEUROSCI.23-27-09208.2003","volume":"23","author":"Goodyear R.J.","year":"2003","unstructured":"Goodyear R.J.; Legan P.K.; Wright M.B.; Marcotti W.; Oganesian A.; Coats S.A.; Booth C.J.; Kros C.J.; Seifert R.A.; Bowen-Pope D.F.; Richardson G.P.; A receptor-like inositol lipid phosphatase is required for the maturation of developing cochlear hair bundles. J Neurosci 2003,23(27),9208-9219","journal-title":"J Neurosci"},{"key":"ref=13","doi-asserted-by":"publisher","first-page":"1754","DOI":"10.1126\/science.7540771","volume":"268","author":"Jia Z.","year":"1995","unstructured":"Jia Z.; Barford D.; Flint A.J.; Tonks N.K.; Structural basis for phosphotyrosine peptide recognition by protein tyrosine phosphatase 1B. Science 1995,268(5218),1754-1758","journal-title":"Science"},{"key":"ref=14","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1107\/S0907444913010457","volume":"69","author":"Yu K.R.","year":"2013","unstructured":"Yu K.R.; Kim Y.J.; Jung S.K.; Ku B.; Park H.; Cho S.Y.; Jung H.; Chung S.J.; Bae K.H.; Lee S.C.; Kim B.Y.; Erikson R.L.; Ryu S.E.; Kim S.J.; Structural basis for the dephosphorylating activity of PTPRQ towards phosphatidylinositide substrates. Acta Crystallogr D Biol Crystallogr 2013,69(Pt 8),1522-1529","journal-title":"Acta Crystallogr D Biol Crystallogr"},{"key":"ref=15","doi-asserted-by":"publisher","first-page":"7563","DOI":"10.1073\/pnas.1336511100","volume":"100","author":"Oganesian A.","year":"2003","unstructured":"Oganesian A.; Poot M.; Daum G.; Coats S.A.; Wright M.B.; Seifert R.A.; Bowen-Pope D.F.; Protein tyrosine phosphatase RQ is a phosphatidylinositol phosphatase that can regulate cell survival and proliferation. Proc Natl Acad Sci USA 2003,100(13),7563-7568","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref=16","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1186\/s12967-019-2099-5","volume":"17","author":"Ozi\u0119b\u0142o D.","year":"2019","unstructured":"Ozi\u0119b\u0142o D.; Sarosiak A.; Leja M.L.; Budde B.S.; Tacikowska G.; Di Donato N.; Bolz H.J.; N\u00fcrnberg P.; Skar\u017cy\u0144ski H.; O\u0142dak M.; First confirmatory study on PTPRQ as an autosomal dominant non-syndromic hearing loss gene. J Transl Med 2019,17(1),351","journal-title":"J Transl Med"},{"key":"ref=17","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/9425725","volume":"2018","author":"Wu X.","year":"2018","unstructured":"Wu X.; Wang S.; Chen S.; Wen Y.Y.; Liu B.; Xie W.; Li D.; Liu L.; Huang X.; Sun Y.; Kong W.J.; Autosomal recessive congenital sensorineural hearing loss due to a novel compound heterozygous PTPRQ mutation in a Chinese family. Neural Plast 2018,2018","journal-title":"Neural Plast"},{"key":"ref=18","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1136\/jmg.2009.075697","volume":"47","author":"Shahin H.","year":"2010","unstructured":"Shahin H.; Rahil M.; Abu Rayan A.; Avraham K.B.; King M.C.; Kanaan M.; Walsh T.; Nonsense mutation of the stereociliar membrane protein gene PTPRQ in human hearing loss DFNB84. J Med Genet 2010,47(9),643-645","journal-title":"J Med Genet"},{"key":"ref=19","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1023\/A:1007061819934","volume":"28","author":"Denman-Johnson K.","year":"1999","unstructured":"Denman-Johnson K.; Forge A.; Establishment of hair bundle polarity and orientation in the developing vestibular system of the mouse. J Neurocytol 1999,28(10-11),821-835","journal-title":"J Neurocytol"},{"key":"ref=20","doi-asserted-by":"publisher","first-page":"528","DOI":"10.1002\/cm.20275","volume":"65","author":"Sakaguchi H.","year":"2008","unstructured":"Sakaguchi H.; Tokita J.; Naoz M.; Bowen-Pope D.; Gov N.S.; Kachar B.; Dynamic compartmentalization of protein tyrosine phosphatase receptor Q at the proximal end of stereocilia: Implication of myosin VI-based transport. Cell Motil Cytoskeleton 2008,65(7),528-538","journal-title":"Cell Motil Cytoskeleton"},{"key":"ref=21","doi-asserted-by":"publisher","first-page":"184S","DOI":"10.1177\/0003489415575041","volume":"124","author":"Sakuma N.","year":"2015","unstructured":"Sakuma N.; Moteki H.; Azaiez H.; Booth K.T.; Takahashi M.; Arai Y.; Shearer A.E.; Sloan C.M.; Nishio S.Y.; Kolbe D.L.; Iwasaki S.; Oridate N.; Smith R.J.; Usami S.; Novel PTPRQ mutations identified in three congenital hearing loss patients with various types of hearing loss. Ann Otol Rhinol Laryngol 2015,124(Suppl. 1),184S-192S","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"ref=22","doi-asserted-by":"publisher","first-page":"639","DOI":"10.3389\/fgene.2019.00639","volume":"10","author":"Sang S.","year":"2019","unstructured":"Sang S.; Ling J.; Liu X.; Mei L.; Cai X.; Li T.; Li W.; Li M.; Wen J.; Liu X.; Liu J.; Liu Y.; Chen H.; He C.; Feng Y.; Proband whole-exome sequencing identified genes responsible for autosomal recessive non-syndromic hearing loss in 33 Chinese nuclear families. Front Genet 2019,10,639","journal-title":"Front Genet"},{"key":"ref=23","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1186\/s12920-021-00871-9","volume":"14","author":"Yang G.","year":"2021","unstructured":"Yang G.; Yin Y.; Tan Z.; Liu J.; Deng X.; Yang Y.; Whole-exome sequencing identified a novel heterozygous mutation of SALL1 and a new homozygous mutation of PTPRQ in a Chinese family with Townes-Brocks syndrome and hearing loss. BMC Med Genom 2021,14(1),24","journal-title":"BMC Med Genom"},{"key":"ref=24","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1016\/j.ajhg.2010.02.015","volume":"86","author":"Schraders M.","year":"2010","unstructured":"Schraders M.; Oostrik J.; Huygen P.L.; Strom T.M.; van Wijk E.; Kunst H.P.; Hoefsloot L.H.; Cremers C.W.; Admiraal R.J.; Kremer H.; Mutations in PTPRQ are a cause of autosomal-recessive nonsyndromic hearing impairment DFNB84 and associated with vestibular dysfunction. Am J Hum Genet 2010,86(4),604-610","journal-title":"Am J Hum Genet"},{"key":"ref=25","doi-asserted-by":"publisher","first-page":"1135","DOI":"10.1007\/s00438-014-0979-1","volume":"290","author":"Sang Q.","year":"2015","unstructured":"Sang Q.; Mei H.; Kuermanhan A.; Feng R.; Guo L.; Qu R.; Xu Y.; Li H.; Jin L.; He L.; Wang L.; Identification of a novel compound heterozygous mutation in PTPRQ in a DFNB84 family with prelingual sensorineural hearing impairment. Mol Genet Genomics 2015,290(3),1135-1139","journal-title":"Mol Genet Genomics"},{"key":"ref=26","doi-asserted-by":"publisher","first-page":"127","DOI":"10.22074\/cellj.2018.4805","volume":"20","author":"Talebi F.","year":"2018","unstructured":"Talebi F.; Ghanbari Mardasi F.; Mohammadi Asl J.; Tizno S.; Najafvand Zadeh M.; Identification of novel PTPRQ and MYO1A mutations in an Iranian Pedigree with autosomal recessive hearing loss. Cell J 2018,20(1),127-131","journal-title":"Cell J"},{"key":"ref=27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124757","volume":"10","author":"Gao X.","year":"2015","unstructured":"Gao X.; Su Y.; Chen Y.L.; Han M.Y.; Yuan Y.Y.; Xu J.C.; Xin F.; Zhang M.G.; Huang S.S.; Wang G.J.; Kang D.Y.; Guan L.P.; Zhang J.G.; Dai P.; Identification of two novel compound heterozygous PTPRQ mutations associated with autosomal recessive hearing loss in a Chinese family. PLoS One 2015,10(4)","journal-title":"PLoS One"},{"key":"ref=28","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1002\/mgg3.131","volume":"3","author":"Ammar-Khodja F.","year":"2015","unstructured":"Ammar-Khodja F.; Bonnet C.; Dahmani M.; Ouhab S.; Lef\u00e8vre G.M.; Ibrahim H.; Hardelin J.P.; Weil D.; Louha M.; Petit C.; Diversity of the causal genes in hearing impaired Algerian individuals identified by whole exome sequencing. Mol Genet Genomic Med 2015,3(3),189-196","journal-title":"Mol Genet Genomic Med"},{"key":"ref=29","doi-asserted-by":"publisher","first-page":"614","DOI":"10.1038\/gim.2017.155","volume":"20","author":"Eisenberger T.","year":"2018","unstructured":"Eisenberger T.; Di Donato N.; Decker C.; Delle Vedove A.; Neuhaus C.; N\u00fcrnberg G.; Toliat M.; N\u00fcrnberg P.; M\u00fcrbe D.; Bolz H.J.; A C-terminal nonsense mutation links PTPRQ with autosomal-dominant hearing loss, DFNA73. Genet Med 2018,20(6),614-621","journal-title":"Genet Med"},{"key":"ref=30","doi-asserted-by":"publisher","first-page":"3034","DOI":"10.3892\/mmr.2017.7015","volume":"16","author":"Nagata Y.","year":"2017","unstructured":"Nagata Y.; Bundo M.; Sugiura S.; Kamita M.; Ono M.; Hattori K.; Yoshida S.; Goto Y.I.; Urakami K.; Niida S.; PTPRQ as a potential biomarker for idiopathic normal pressure hydrocephalus. Mol Med Rep 2017,16(3),3034-3040","journal-title":"Mol Med Rep"},{"key":"ref=31","doi-asserted-by":"publisher","first-page":"389","DOI":"10.1111\/ene.14575","volume":"28","author":"Nakajima M.","year":"2021","unstructured":"Nakajima M.; Rauramaa T.; M\u00e4kinen P.M.; Hiltunen M.; Herukka S.K.; Kokki M.; Musialowicz T.; Jyrkk\u00e4nen H.K.; Danner N.; Junkkari A.; Koivisto A.M.; J\u00e4\u00e4skel\u00e4inen J.E.; Miyajima M.; Ogino I.; Furuta A.; Akiba C.; Kawamura K.; Kamohara C.; Sugano H.; Tange Y.; Karagiozov K.; Leinonen V.; Arai H.; Protein tyrosine phosphatase receptor type Q in cerebrospinal fluid reflects ependymal cell dysfunction and is a potential biomarker for adult chronic hydrocephalus. Eur J Neurol 2021,28(2),389-400","journal-title":"Eur J Neurol"},{"key":"ref=32","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107966","volume":"230","author":"Song Y.","year":"2022","unstructured":"Song Y.; Zhao M.; Zhang H.; Yu B.; Double-edged roles of protein tyrosine phosphatase SHP2 in cancer and its inhibitors in clinical trials. Pharmacol Ther 2022,230","journal-title":"Pharmacol Ther"},{"key":"ref=33","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1002\/humu.22630","volume":"35","author":"Walia V.","year":"2014","unstructured":"Walia V.; Prickett T.D.; Kim J.S.; Gartner J.J.; Lin J.C.; Zhou M.; Rosenberg S.A.; Elble R.C.; Solomon D.A.; Waldman T.; Samuels Y.; Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma. Hum Mutat 2014,35(11),1301-1310","journal-title":"Hum Mutat"},{"key":"ref=34","doi-asserted-by":"publisher","first-page":"13434","DOI":"10.18632\/oncotarget.3876","volume":"6","author":"Cheung A.K.","year":"2015","unstructured":"Cheung A.K.; Ip J.C.; Chu A.C.; Cheng Y.; Leong M.M.; Ko J.M.; Shuen W.H.; Lung H.L.; Lung M.L.; PTPRG suppresses tumor growth and invasion via inhibition of Akt signaling in nasopharyngeal carcinoma. Oncotarget 2015,6(15),13434-13447","journal-title":"Oncotarget"},{"key":"ref=35","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1080\/15592294.2019.1676597","volume":"15","author":"Sen M.","year":"2020","unstructured":"Sen M.; Kindsfather A.; Danilova L.; Zhang F.; Colombo R.; LaPorte M.G.; Kurland B.F.; Huryn D.M.; Wipf P.; Herman J.G.; PTPRT epigenetic silencing defines lung cancer with STAT3 activation and can direct STAT3 targeted therapies. Epigenetics 2020,15(6-7),604-617","journal-title":"Epigenetics"},{"key":"ref=36","doi-asserted-by":"publisher","first-page":"410","DOI":"10.1038\/onc.2016.213","volume":"36","author":"Dong H.","year":"2017","unstructured":"Dong H.; Ma L.; Gan J.; Lin W.; Chen C.; Yao Z.; Du L.; Zheng L.; Ke C.; Huang X.; Song H.; Kumar R.; Yeung S.C.; Zhang H.; PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2. Oncogene 2017,36(3),410-422","journal-title":"Oncogene"},{"key":"ref=37","author":"Koh Y.","year":"2014","unstructured":"Koh Y.; Kim D-Y.; Yook J.; Park H.; Lee C-S.; Ahn K-S.; Lee H-J.;  Whole exome sequencing of acute myeloid leukemia patients in Korea and its comparison with TCGA results: Dramatic difference of genomic signatures according to ethnicity 2014","journal-title":"Whole exome sequencing of acute myeloid leukemia patients in Korea and its comparison with TCGA results: Dramatic difference of genomic signatures according to ethnicity"},{"key":"ref=38","first-page":"677","volume":"36","author":"Laczmanska I.","year":"2016","unstructured":"Laczmanska I.; Karpinski P.; Gil J.; Laczmanski L.; Bebenek M.; Sasiadek M.M.; High PTPRQ expression and its relationship to expression of PTPRZ1 and the presence of KRAS mutations in colorectal cancer tissues. Anticancer Res 2016,36(2),677-681","journal-title":"Anticancer Res"},{"key":"ref=39","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/8032910","volume":"2017","author":"Sato R.","year":"2017","unstructured":"Sato R.; Nakano T.; Hosonaga M.; Sampetrean O.; Harigai R.; Sasaki T.; Koya I.; Okano H.; Kudoh J.; Saya H.; Arima Y.; RNA sequencing analysis reveals interactions between breast cancer or melanoma cells and the tissue microenvironment during brain metastasis. BioMed Res Int 2017,2017","journal-title":"BioMed Res Int"},{"key":"ref=40","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.540094","volume":"11","author":"Yang Q.","year":"2020","unstructured":"Yang Q.; Chu W.; Yang W.; Cheng Y.; Chu C.; Pan X.; Ye J.; Cao J.; Gan S.; Cui X.; Identification of RNA transcript makers associated with prognosis of kidney renal clear cell carcinoma by a competing endogenous RNA network analysis. Front Genet 2020,11","journal-title":"Front Genet"},{"key":"ref=41","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1016\/j.bbrc.2009.04.001","volume":"383","author":"Jung H.","year":"2009","unstructured":"Jung H.; Kim W.K.; Kim D.H.; Cho Y.S.; Kim S.J.; Park S.G.; Park B.C.; Lim H.M.; Bae K.H.; Lee S.C.; Involvement of PTP-RQ in differentiation during adipogenesis of human mesenchymal stem cells. Biochem Biophys Res Commun 2009,383(2),252-257","journal-title":"Biochem Biophys Res Commun"},{"key":"ref=42","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1186\/1742-4682-10-49","volume":"10","author":"Park H.","year":"2013","unstructured":"Park H.; Yu K.R.; Ku B.; Kim B.Y.; Kim S.J.; Identification of novel PTPRQ phosphatase inhibitors based on the virtual screening with docking simulations. Theor Biol Med Model 2013,10(1),49","journal-title":"Theor Biol Med Model"}],"container-title":["Protein &amp; Peptide Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0929866529666220511141826","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/204600\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/article\/download?doi=10.2174\/0929866529666220511141826","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T16:55:43Z","timestamp":1692896143000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/204600\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929866529666220511141826","relation":{},"ISSN":["0929-8665"],"issn-type":[{"value":"0929-8665","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2022-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-10","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}