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The activity\nof Nrf2 is tightly regulated by KEAP1, which promotes ubiquitination, followed by degradation\nunder homeostatic conditions and also allows Nrf2 to escape ubiquitination, accumulate within the\ncell, and translocate in the nucleus upon exposure to the stresses. The Nrf2 pathway has shown an\nintrinsic mechanism of defense against oxidative stress (OS). It emerged as a promising therapeutic\ntarget as both inducers and as there is an increasing number of evidence for the protective role of the\nNrf2-ARE pathway towards exacerbations of ROS generation as well as OS, mitochondrial\ndysfunction as well as prolonged neuroinflammation is a prevalent pathophysiological process\nrooted in brain-related disorders. Elevated concentrations of ROS generation and OS have been\nlinked to the pathophysiology of a diverse array of brain related disorders, including Alzheimer\u2019s\ndisease, Parkinson\u2019s disease, Huntington\u2019s disease, Friedrich\u2019s ataxia, multiple sclerosis, and\nepilepsy. Further, it not only modulates the articulation of anti-oxidant genes but has often been\nassociated with implicating anti-inflammatory consequences as well as regulating mitochondrial\nfunctionalities and biogenesis. Therefore, Nrf2 can be considered a potential therapeutic target for\nthe regimen of various brain-related disorders.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929866529666220622124253","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T05:01:16Z","timestamp":1655960476000},"page":"676-691","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Basic Leucine Zipper Protein Nuclear Factor Erythroid 2\u2013related Factor 2\nas a Potential Therapeutic Target in Brain Related Disorders"],"prefix":"10.2174","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0110-9238","authenticated-orcid":true,"given":"Ahsas","family":"Goyal","sequence":"first","affiliation":[{"name":"Institute of Pharmaceutical Research, GLA University, Mathura-281406, U.P., India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Gopika","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical\nSciences, MVN University, Palwal-121105, Haryana, India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7575-3670","authenticated-orcid":true,"given":"Neetu","family":"Agrawal","sequence":"additional","affiliation":[{"name":"Institute of Pharmaceutical Research, GLA University, Mathura-281406, U.P., India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"4125","DOI":"10.1113\/jphysiol.2011.210294","volume":"589","author":"Alfieri A.","year":"2011","unstructured":"Alfieri A.; Srivastava S.; Siow R.C.M.; Modo M.; Fraser P.A.; Mann G.E.; Targeting the Nrf2-Keap1 antioxidant defence pathway for neurovascular protection in stroke. 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