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The serial inhibition kinetics and spectrofluorimetry measurements were performed to\nvalidate the inhibitory effect on tyrosinase.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>We have detected 200 candidates and categorized them into four clusters. Among them, we\nsuccessfully confirmed salsalate as a new inhibitor of tyrosinase measured by serial enzyme\nkinetics. Salsalate was detected as a reversible inhibitor of tyrosinase displaying a typical mixedtype\ninhibition manner (IC50 = 22.19 \u00b1 1.01 mM; Ki = 19.98 \u00b1 2.11 mM). Spectrofluorimetry\nmeasurement by integrating with 1-anilinonaphthalene-8-sulfonate showed that salsalate mainly\ninduced a slight regional conformation distortion of the tyrosinase active site accompanied by a\nslight hydrophobic disruption.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Our study suggests that salsalate is a potential anti-pigment drug via inhibition of\ntyrosinase activity and it might be applicable for dermatologic clinical application. Also, our study\nenlarges an insight into the salsalate drug application.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929866529666220805145244","type":"journal-article","created":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T11:56:37Z","timestamp":1659700597000},"page":"744-759","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Application of Computational Simulation Integrating Inhibition Kinetics\nfor Detecting Tyrosinase Inhibitor: Salsalate Is a New Inhibitor"],"prefix":"10.2174","volume":"29","author":[{"given":"Jie-Hao","family":"Xu","sequence":"first","affiliation":[{"name":"College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo, 315100, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhyuk","family":"Lee","sequence":"additional","affiliation":[{"name":"Genome\nEditing Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Gwahak-ro, Yuseong-gu,\nDaejeon, 34141, Korea"},{"name":"Department of Bioinformatics, KRIBB School of Bioscience, University of Science and\nTechnology (UST), 217 Gajung-ro, Yuseong-gu, Daejeon 34113, Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo, 315100, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Doo","family":"Park","sequence":"additional","affiliation":[{"name":"College of Biological and Environmental Sciences, Zhejiang Wanli University, Ningbo, 315100, PR China"},{"name":"Skin Diseases Research Center, Yangtze Delta\nRegion Institute of Tsinghua University, 705 Yatai Road, Jiaxing 314006, PR China"},{"name":"Zhejiang Provincial Key\nLaboratory of Applied Enzymology, Yangtze Delta Region Institute of Tsinghua University, 705 Yatai Road, Jiaxing\n314006, P.R. 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