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These proteins are expressed at low levels in various normal cells, tissues, and organs but can be upregulated upon stimulation by multiple stressors. Studies have shown that CIRP and RBM3 are multifunctional RNA molecular chaperones with different biological functions in various physiological and pathophysiological processes, such as reproductive development, the inflammatory response, the immune response, nerve injury regulation, and tumorigenesis. This paper reviews recent studies on the structure, localization and correlation of CIRP and RBM3 with reproductive development and reproductive system diseases.<\/jats:p><\/jats:sec>","DOI":"10.2174\/0929866530666221124122507","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T06:00:17Z","timestamp":1669356017000},"page":"2-12","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cold-Induced RNA-Binding Protein and RNA-Binding Motif Protein 3: Two RNA Molecular Chaperones Closely Related to Reproductive Development and Reproductive System Diseases"],"prefix":"10.2174","volume":"30","author":[{"given":"Yuji","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Medicine, Jilin Medical University, Jilin City, Jilin Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine, Jilin Medical University, Jilin City, Jilin Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahao","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Jilin Medical University, Jilin City, Jilin Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qinqin","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Jilin Medical University, Jilin City, Jilin Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingji","family":"Jin","sequence":"additional","affiliation":[{"name":"Dermatology Department, Affiliated Hospital of Yanbian University, Yanbian City, Jilin Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"8800","DOI":"10.1073\/pnas.85.23.8800","volume":"85","author":"Fornace A.J.","year":"1988","unstructured":"Fornace A.J.; Alamo I.; Hollander M.C.; DNA damage-inducible transcripts in mammalian cells. 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