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The rapid increase in the number of cases\nkindles a need for quick, inexpensive diagnostic tests for the epidemiological control of the disease.\nThe high cost of molecular tests can make this control more difficult to access in poorer regions, with\nimmunological tests being a more viable option. In this mini-review, a search was conducted in the\nmain databases for peptide and protein options that could be used in the development of serological\ndiagnostic tests. Nine viable registres were found, and seven were selected (two patents and five\nstudies). The main studies used the B21R peptide sequence as it is a high immunogenic epitope. In\naddition, studies on the improvement of these sequences were also found to avoid cross-reactions\nagainst other viruses of the same family, proposing a rational approach using multiepitope\nrecombinant proteins. These approaches demonstrated high sensitivity and specificity values and are\nseen as viable options for developing new tests. New effective serological testing options, when\ncombined with awareness, disease surveillance, early diagnosis, and rapid communication, form a set\nof key strategies used by health systems to control the spread of the monkeypox virus.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929866530666230328094425","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T03:58:20Z","timestamp":1680235100000},"page":"374-383","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["A Mini-review on Potentials Proteins\/Peptides Applied for Serodiagnosis\nof Human Monkeypox Infection and Future Trends"],"prefix":"10.2174","volume":"30","author":[{"given":"Fellipe Alexandre Alves","family":"Moraes","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Disciplina Biotecnologia &amp; Inova\u00e7\u00f5es, Programa de P\u00f3s-gradua\u00e7\u00e3o em Biotecnologia e\nPrograma Multicentrico de P\u00f3s-gradua\u00e7\u00e3o em Bioqu\u00edmica e Biologia Molecular, Universidade Federal de S\u00e3o Jo\u00e3o\nDel-Rei, Divin\u00f3polis, MG, 35501-296, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ca\u00edque Lopes","family":"Duarte","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Disciplina Biotecnologia &amp; Inova\u00e7\u00f5es, Programa de P\u00f3s-gradua\u00e7\u00e3o em Biotecnologia e\nPrograma Multicentrico de P\u00f3s-gradua\u00e7\u00e3o em Bioqu\u00edmica e Biologia Molecular, Universidade Federal de S\u00e3o Jo\u00e3o\nDel-Rei, Divin\u00f3polis, MG, 35501-296, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Oliveira","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Disciplina Biotecnologia &amp; Inova\u00e7\u00f5es, Programa de P\u00f3s-gradua\u00e7\u00e3o em Biotecnologia e\nPrograma Multicentrico de P\u00f3s-gradua\u00e7\u00e3o em Bioqu\u00edmica e Biologia Molecular, Universidade Federal de S\u00e3o Jo\u00e3o\nDel-Rei, Divin\u00f3polis, MG, 35501-296, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas Ant\u00f4nio","family":"Lisboa Ribeiro","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Disciplina Biotecnologia &amp; Inova\u00e7\u00f5es, Programa de P\u00f3s-gradua\u00e7\u00e3o em Biotecnologia e\nPrograma Multicentrico de P\u00f3s-gradua\u00e7\u00e3o em Bioqu\u00edmica e Biologia Molecular, Universidade Federal de S\u00e3o Jo\u00e3o\nDel-Rei, Divin\u00f3polis, MG, 35501-296, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciana Martins","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Disciplina Biotecnologia &amp; Inova\u00e7\u00f5es, Programa de P\u00f3s-gradua\u00e7\u00e3o em Biotecnologia e\nPrograma Multicentrico de P\u00f3s-gradua\u00e7\u00e3o em Bioqu\u00edmica e Biologia Molecular, Universidade Federal de S\u00e3o Jo\u00e3o\nDel-Rei, Divin\u00f3polis, MG, 35501-296, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junivania Aparecida","family":"dos Santos Lacerda","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Disciplina Biotecnologia &amp; Inova\u00e7\u00f5es, Programa de P\u00f3s-gradua\u00e7\u00e3o em Biotecnologia e\nPrograma Multicentrico de P\u00f3s-gradua\u00e7\u00e3o em Bioqu\u00edmica e Biologia Molecular, Universidade Federal de S\u00e3o Jo\u00e3o\nDel-Rei, Divin\u00f3polis, MG, 35501-296, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L\u00edria Souza","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Laborat\u00f3rio de Biotecnologia de\nMicrorganismos, Universidade Federal de S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, MG, 35501-296, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jonatas Oliveira","family":"da Silva","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Laborat\u00f3rio de Biotecnologia de\nMicrorganismos, Universidade Federal de S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, MG, 35501-296, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelli","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Laborat\u00f3rio de Biotecnologia de\nMicrorganismos, Universidade Federal de S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, MG, 35501-296, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"da Silva Dantas","sequence":"additional","affiliation":[{"name":"School of Dental\nSciences, Newcasttle University, Flalington Place, New Casttle upon Tyne, New Casttle, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel Angel","family":"Ch\u00e1vez-Fumagalli","sequence":"additional","affiliation":[{"name":"Computational Biology\nand Chemistry Research Group, Vicerrectorado de Investigaci\u00f3n, Universidad Cat\u00f3lica de Santa Mar\u00eda, Arequipa,\nPeru"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Campos-da-Paz","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Laborat\u00f3rio de Bioativos e Nanobiotecnologia, Universidade Federal de S\u00e3o Jo\u00e3o\nDel-Rei, Divin\u00f3polis, MG, 35501-296, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo Cordeiro","family":"Giunchetti","sequence":"additional","affiliation":[{"name":"Department of Morphology, Laboratory of Cell-Cell Interactions,\nInstitute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, 31270-901, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Ant\u00f4nio","family":"Ferraz Coelho","sequence":"additional","affiliation":[{"name":"Programa de P\u00f3s-Gradua\u00e7\u00e3o em Ci\u00eancias da Sa\u00fade: Infectologia e Medicina Tropical, Faculdade de Medicina,\nUniversidade Federal de Minas Gerais, Belo Horizonte, 30130-100, Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Martins","family":"Machado","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Laborat\u00f3rio de Biotecnologia de\nMicrorganismos, Universidade Federal de S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, MG, 35501-296, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexsandro Sobreira","family":"Galdino","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Laborat\u00f3rio de Biotecnologia de\nMicrorganismos, Universidade Federal de S\u00e3o Jo\u00e3o Del-Rei, Divin\u00f3polis, MG, 35501-296, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"e0010141","DOI":"10.1371\/journal.pntd.0010141","volume":"16","author":"Bunge E.M.","year":"2022","unstructured":"Bunge E.M.; 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