{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T12:44:50Z","timestamp":1782737090760,"version":"3.54.5"},"reference-count":49,"publisher":"Bentham Science Publishers Ltd.","issue":"7","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["PPL"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p>Sevoflurane (Sev) is a type of volatile anesthetic commonly used in clinic\npractices and can initiate long-term neurotoxicity, while dexmedetomidine (Dex) possesses a\nneuroprotective function in multiple neurological disorders.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Objective:<\/jats:title>\n<jats:p>This work expounded on the function of Dex pretreatment in Sev-initiated neurotoxicity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Methods:<\/jats:title>\n<jats:p>At first, human neuroblastoma cells (SK-N-SH cells) were treated with different\nconcentrations of Sev or Dex, followed by the cell counting kit (CCK)-8 assay to decide the\nappropriate concentrations of Sev or Dex. Cell viability, lactate dehydrogenase (LDH) productions,\nand apoptotic rate of SK-N-SH cells were examined by the CCK-8 assay, LDH cytotoxicity kit, and\nflow cytometry assay in sequence. Further, reactive oxygen species (ROS) levels and proinflammatory\ncytokine contents were examined by the ROS assay kit and the enzyme-linked\nimmunosorbent assay kits. The expression patterns of microRNA (miR)-204-5p and SRY-box\ntranscription factor 4 (SOX4) in SK-N-SH cells were measured by real-time quantitative polymerase\nchain reaction or Western blotting. The binding relationship between miR-204-5p and SOX4 was\nconfirmed by the dual-luciferase assay. After transfection of miR-204-5p mimics or SOX4 siRNA,\nthe role of the miR-204-5p\/SOX4 axis in Sev-initiated neurotoxicity was detected.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p>Sev treatment reduced SK-N-SH cell viability in a concentration-dependent manner, and Dex\npretreatment diminished Sev-initiated neurotoxicity. Mechanically, Dex pretreatment limited Sevinduced\nupregulation of miR-204-5p and further increased SOX4 expression levels. miR-204-5p\nupregulation or SOX4 knockdown averted the neuroprotection function of Dex pretreatment in Sevinitiated\nneurotoxicity.<\/jats:p>\n<\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>Dex pretreatment decreased miR-204-5p expression levels and upregulated SOX4\nexpression levels, palliating Sev-initiated neurotoxicity.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929866530666230530164913","type":"journal-article","created":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T04:01:45Z","timestamp":1685592105000},"page":"608-618","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Neuroprotective Effect of Dexmedetomidine Pretreatment on Sevoflurane-\nInitiated Neurotoxicity <i>Via<\/i> the Mir-204-5p\/SOX4 Axis"],"prefix":"10.2174","volume":"30","author":[{"given":"Run","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing, 100038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pengfei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing, 100038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing, 100038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Beijing Shijitan Hospital Affiliated to Capital Medical University, Beijing, 100038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","reference":[{"key":"ref=1","doi-asserted-by":"publisher","first-page":"CD007084","DOI":"10.1002\/14651858.CD007084.pub2","author":"Costi D.","year":"2014","unstructured":"Costi D.; Cyna A.M.; Ahmed S.; Stephens K.; Strickland P.; Ellwood J.; Larsson J.N.; Chooi C.; Burgoyne L.L.; Middleton P.; Effects of sevoflurane versus other general anaesthesia on emergence agitation in children. 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