{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T22:45:34Z","timestamp":1792795534982,"version":"4.5.0"},"reference-count":0,"publisher":"Bentham Science Publishers Ltd.","issue":"1","content-domain":{"domain":["eurekaselect.com"],"crossmark-restriction":true},"short-container-title":["CMC"],"published-print":{"date-parts":[[2018,1,22]]},"abstract":"<jats:sec>\n<jats:title>Background:<\/jats:title>\n<jats:p> Research into gold-based drugs for a range of human diseases has seen a\nrevival in recent years. This article reviews the most important applications of gold products in different\nfields of human pathology. Au(I) and Au(III) compounds have been re-introduced in clinical\npractice for targeting the cellular components involved in the onset and progression of viral and\nparasitic diseases, rheumatoid arthritis and cancer.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results:<\/jats:title>\n<jats:p> After some brief historical notes, this article takes into account the applications of gold\ncompounds against Mycobacterium tuberculosis, and also in tuberculosis and in rheumatoid arthritis\ntreatment. The use of gold containing drugs in the cure of cancer are then considered, with special\nemphasis to the use of nanoparticles and to the photo-thermal cancer therapy. The use of colloidal\ngold in diagnostics, introduced in the last decade is widely discussed. As a last point a survey\non the adverse effects and on the toxicity of the various gold derivatives in use in medicine is\npresented.\n<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusion:<\/jats:title>\n<jats:p>In this review, we described the surprisingly broad spectrum of possible uses of gold\nin diagnostics and in therapeutic approaches to multiple human diseases, ranging from degenerative\nto infectious diseases, and to cancer. In particular, gold nanoparticles appear as attractive elements\nin modern clinical medicine, combining high therapeutic properties, high selectivity in targeting\ncancer cells and low toxicity.<\/jats:p>\n<\/jats:sec>","DOI":"10.2174\/0929867324666170330091438","type":"journal-article","created":{"date-parts":[[2017,3,31]],"date-time":"2017-03-31T06:59:02Z","timestamp":1490943542000},"page":"75-84","update-policy":"https:\/\/doi.org\/10.2174\/bsp_crossmark_policy","source":"Crossref","is-referenced-by-count":57,"title":["Gold - Old Drug with New Potentials"],"prefix":"10.2174","volume":"25","author":[{"given":"Gavino","family":"Faa","sequence":"first","affiliation":[{"name":"Dipartimento di Scienze Chirurgiche, Anatomia Patologica, University of Cagliari, Via Ospedale 46, I- 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Gerosa","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chirurgiche, Anatomia Patologica, University of Cagliari, Via Ospedale 46, I- 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Fanni","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chirurgiche, Anatomia Patologica, University of Cagliari, Via Ospedale 46, I- 09124 Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna I.","family":"Lachowicz","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche e Geologiche, University of Cagliari, Cittadella Universitaria, I-09042 Monserrato-Cagliari, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria M.","family":"Nurchi","sequence":"additional","affiliation":[{"name":"Dipartimento di Scienze Chimiche e Geologiche, University of Cagliari, Cittadella Universitaria, I-09042 Monserrato-Cagliari, Cagliari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"965","container-title":["Current Medicinal Chemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/eurekaselect.com\/article\/download\/151210","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.eurekaselect.com\/151210\/article","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/eurekaselect.com\/article\/download\/151210","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,25]],"date-time":"2020-12-25T10:00:19Z","timestamp":1608890419000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.eurekaselect.com\/151210\/article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,22]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1,22]]}},"alternative-id":["LiveAll1"],"URL":"https:\/\/doi.org\/10.2174\/0929867324666170330091438","relation":{},"ISSN":["0929-8673"],"issn-type":[{"value":"0929-8673","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1,22]]},"assertion":[{"value":"Peer Reviewed","order":0,"name":"review_status","label":"Review Status","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Single blind","order":1,"name":"review_process","label":"Review Process","group":{"name":"peer_review_details","label":"Peer Review Details"}},{"value":"Checked with iThenticate","order":0,"name":"screening_status","label":"Screening Status","group":{"name":"plagiarism_screening","label":"Plagiarism Screening"}},{"value":"2016-10-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-02-03","order":1,"name":"revised","label":"Revised","group":{"name":"publication_history","label":"Publication History"}},{"value":"2017-03-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-01-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}